Structure activity Relationship - Page 9

5-Aryl-1,2-dihydrochromeno[3,4- f ]quinolines: A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists

Organic Chemistry / Medicinal Chemistry / Magnetic Resonance Spectroscopy / Humans / Female / Animals / Rats / Medicinal / Quinolines / Structure activity Relationship / Uterus / Animals / Rats / Medicinal / Quinolines / Structure activity Relationship / Uterus

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Molecular Recognition in a Lattice Model: An Enumeration Study

Protein Folding / Sequence alignment / Computer Simulation / Physical sciences / Proteins / Protein Sequence Analysis / Surface Properties / Protein Conformation / Structure activity Relationship / Protein Binding / Protein Sequence Analysis / Surface Properties / Protein Conformation / Structure activity Relationship / Protein Binding

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Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

Organic Chemistry / Humans / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Vascular Endothelial Growth Factor

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Synthetic analogues of antimicrobial peptides from the venom of the Central Asian spider Lachesana tarabaevi

Spiders / Escherichia coli / Animals / Antimicrobial Peptide / Anti-Bacterial Agents / Antimicrobial Cationic Peptides / Bacillus subtilis / Amino Acid Profile / Mechanism of action / Biological activity / Amino Acid Sequence / Structure activity Relationship / Erythrocytes / Hemolysis / Bilayer Lipid Membrane / Disulfide bond / Antimicrobial Cationic Peptides / Bacillus subtilis / Amino Acid Profile / Mechanism of action / Biological activity / Amino Acid Sequence / Structure activity Relationship / Erythrocytes / Hemolysis / Bilayer Lipid Membrane / Disulfide bond

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Preparation and Pharmacological Characterization of trans -2-Amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1 H -indenes as D 2 -like Dopamine Receptor Agonists

Organic Chemistry / Medicinal Chemistry / cyclic AMP / Animals / dopamine receptor D4 / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP

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Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Dogs / Humans / Blood brain barrier / Animals / Drug Design / Rats / Pyrazoles / Structure activity Relationship / cyclic GMP / Molecular Structure / Blood brain barrier / Animals / Drug Design / Rats / Pyrazoles / Structure activity Relationship / cyclic GMP / Molecular Structure

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New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / DBA / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing

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Peptide QSAR on Substance P Analogues, Enkephalins, and Bradykinins Containing L- and D-Amino Acids

Mice / Female / Animals / Male / Rats / Amino Acid Profile / Substance P / Amino Acid Sequence / Structure activity Relationship / Uterus / Ileum / Bradykinin / Amino Acid Profile / Substance P / Amino Acid Sequence / Structure activity Relationship / Uterus / Ileum / Bradykinin

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Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives

Organic Chemistry / Catalysis / Cercopithecus aethiops / Animals / Molecules / Plasmodium falciparum / Leishmania infantum / Structure activity Relationship / Vero cells / Solvents / Plasmodium falciparum / Leishmania infantum / Structure activity Relationship / Vero cells / Solvents

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3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3

Organic Chemistry / Apoptosis / Cell line / Stroke / Escherichia coli / Signal Transduction Pathway Models / Caspase / Protease Inhibitors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Signal Transduction Pathway Models / Caspase / Protease Inhibitors / Bioorganic and medicinal Chemistry / Structure activity Relationship

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Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): A novel class of antimicrobial compounds

Organic Chemistry / Kinetics / Enzyme Inhibitors / Escherichia coli / Anti-Bacterial Agents / Substrate Specificity / Bioorganic and medicinal Chemistry / Structure activity Relationship / Glutamate Dehydrogenase / Molecular Structure / Transaminases / Substrate Specificity / Bioorganic and medicinal Chemistry / Structure activity Relationship / Glutamate Dehydrogenase / Molecular Structure / Transaminases

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Human Glutamate Pyruvate Transaminase (GPT): Localization to 8q24.3, cDNA and Genomic Sequences, and Polymorphic Sites

Information Systems / Genetics / Genomics / Polymorphism / Humans / Animals / Epidermolysis Bullosa / Polymerase Chain Reaction / DNA sequence design / Genetic Map / Biological evolution / Genes / Protein Sequence Analysis / Rats / Fluorescent in situ hybridization / Isoenzymes / Physical Map / Genetic variation / Amino Acid Profile / Genome sequence / Amino Acid Sequence / Base Sequence / Structure activity Relationship / DNA marker / Alanine Transaminase / Animals / Epidermolysis Bullosa / Polymerase Chain Reaction / DNA sequence design / Genetic Map / Biological evolution / Genes / Protein Sequence Analysis / Rats / Fluorescent in situ hybridization / Isoenzymes / Physical Map / Genetic variation / Amino Acid Profile / Genome sequence / Amino Acid Sequence / Base Sequence / Structure activity Relationship / DNA marker / Alanine Transaminase

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Light curable dental composites designed with colloidal crystal reinforcement

Engineering / Crystallization / Dental Materials / Elasticity / Compressive Strength / Colloids / Hardness / Composite resins / Dental Stress Analysis / Polymethyl Methacrylates / Materials Testing / Structure activity Relationship / Silicon Dioxide / Polyethylene Glycols / Colloids / Hardness / Composite resins / Dental Stress Analysis / Polymethyl Methacrylates / Materials Testing / Structure activity Relationship / Silicon Dioxide / Polyethylene Glycols

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Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli

Enzyme Inhibitors / Biological Sciences / Humans / Protein Kinases / Escherichia coli / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure

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Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1 H-pyrrolo[1,2- c]imidazol-1-ones: A new class of Neuropeptide S antagonists

Inorganic Chemistry / Organic Chemistry / Medicinal Chemistry / Calcium / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure

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N -Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds

Pharmacology / Chemistry / Organic Chemistry / Pharmacy / Medicinal Chemistry / Malaria / Humans / Animals / Rats / Hepatocytes / Plasmodium falciparum / Antimalarials / Benzimidazoles / Structure activity Relationship / Plasmodium berghei / Malaria / Humans / Animals / Rats / Hepatocytes / Plasmodium falciparum / Antimalarials / Benzimidazoles / Structure activity Relationship / Plasmodium berghei

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