Structure activity Relationship - Page 15

Tumor-selective amphiphilic para-quinones and tetramic acids

Humans / Structure activity Relationship / Benzoquinones

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Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators

Organic Chemistry / Calcium / Lepidoptera / Insecticides / Pesticide / Pesticides / Animals / Insects / Ryanodine Receptor / Amination / Receptor / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Calcium Ions / Molecular Structure / Intracellular / Pesticides / Animals / Insects / Ryanodine Receptor / Amination / Receptor / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Calcium Ions / Molecular Structure / Intracellular

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In Vitro Activities of the Multifunctional RNA Silencing Polymerase QDE-1 of Neurospora crassa

Biological Chemistry / RNA silencing / Neurospora crassa / Biological Sciences / CHEMICAL SCIENCES / Substrate Specificity / Structure activity Relationship / Site-directed Mutagenesis / Substrate Specificity / Structure activity Relationship / Site-directed Mutagenesis

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Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities

Catalysis / Kinetics / DNA replication / Biological Sciences / Environmental Sciences / Humans / Mutagenesis / Mutation / Nucleic Acids / Multienzyme complexes / Amino Acid Sequence / Amino Acid Substitution Rates / Structure activity Relationship / Humans / Mutagenesis / Mutation / Nucleic Acids / Multienzyme complexes / Amino Acid Sequence / Amino Acid Substitution Rates / Structure activity Relationship

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Sugar nucleotide recognition by Klebsiella pneumoniae UDP-d-galactopyranose mutase: Fluorinated substrates, kinetics and equilibria

Chemistry / Organic Chemistry / Kinetics / Drug Delivery Systems / Fluorine / Anti-Bacterial Agents / Substrate Specificity / Structure activity Relationship / Nucleotides / Klebsiella pneumoniae / Anti-Bacterial Agents / Substrate Specificity / Structure activity Relationship / Nucleotides / Klebsiella pneumoniae

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Ophiobolin E and 8-epi-ophiobolin J produced by Drechslera gigantea, a potential mycoherbicide of weedy grasses

Phytochemistry / Mass Spectrometry / Biological Sciences / Terpenes / Fungal Pathogens / Herbicides / CHEMICAL SCIENCES / Plant extracts / Structure activity Relationship / Ascomycota / Herbicides / CHEMICAL SCIENCES / Plant extracts / Structure activity Relationship / Ascomycota

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Herbicidal Potential of Ophiobolins Produced by Drechslera gigantea

Engineering / Terpenes / Poaceae / Herbicides / CHEMICAL SCIENCES / Agricultural and Food Chemistry / Structure activity Relationship / Ascomycota / Plant Leaves / Agricultural and Food Chemistry / Structure activity Relationship / Ascomycota / Plant Leaves

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Systemic Antibacterial Activity of Novel Synthetic Cyclic Peptides

Microbiology / Medical Microbiology / Treatment Outcome / Antibiotic Resistance / Gram Positive / Mice / Female / Animals / Antimicrobial activity / Staphylococcus aureus / Cyclic peptides / Antimicrobial Peptide / Steady state / Gram Positive Bacteria / Antibacterial activity / Mode of action / Anti-Bacterial Agents / Antimicrobial agents / Microbial Sensitivity Tests / Amino Acid Profile / Peritonitis / Mechanism of action / Membrane Potential / Structure activity Relationship / Food and Drug Administration / Thigh / Effective Dose / Vancomycin Resistant Enterococci (VRE) / Mice / Female / Animals / Antimicrobial activity / Staphylococcus aureus / Cyclic peptides / Antimicrobial Peptide / Steady state / Gram Positive Bacteria / Antibacterial activity / Mode of action / Anti-Bacterial Agents / Antimicrobial agents / Microbial Sensitivity Tests / Amino Acid Profile / Peritonitis / Mechanism of action / Membrane Potential / Structure activity Relationship / Food and Drug Administration / Thigh / Effective Dose / Vancomycin Resistant Enterococci (VRE)

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Imidazopyridines as VLA-4 integrin antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / Animals / Drug Design / Rats / Phenylalanine / Pyridines / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Drug Design / Rats / Phenylalanine / Pyridines / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding

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Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione

Catalysis / Kinetics / Humans / Glutathione / Polycyclic Aromatic Hydrocarbon / Carcinogens / Polycyclic aromatic hydrocarbons (PAHs) / Active site / Genetic variation / Glutathione Transferase / Biological activity / Individual Difference / Structure activity Relationship / Epidemiologic Studies / Biochemistry and cell biology / Molecular Structure / Carcinogens / Polycyclic aromatic hydrocarbons (PAHs) / Active site / Genetic variation / Glutathione Transferase / Biological activity / Individual Difference / Structure activity Relationship / Epidemiologic Studies / Biochemistry and cell biology / Molecular Structure

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Allosteric 1-Adrenoreceptor Antagonism by the Conopeptide -TIA

Kinetics / Fluorescence Microscopy / Biological Chemistry / Biological Sciences / Smooth muscle / Animals / Male / Peptides / CHEMICAL SCIENCES / Rats / Time Factors / Arginine / Wistar Rats / Protein Conformation / Alanine / Amino Acid Sequence / Structure activity Relationship / Protein Binding / Binding Site / Full Length Movies / Animals / Male / Peptides / CHEMICAL SCIENCES / Rats / Time Factors / Arginine / Wistar Rats / Protein Conformation / Alanine / Amino Acid Sequence / Structure activity Relationship / Protein Binding / Binding Site / Full Length Movies

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Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli

Enzyme Inhibitors / Biological Sciences / Humans / Protein Kinases / Escherichia coli / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure

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Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides

Organic Chemistry / Humans / Mice / Animals / Trypanosoma Cruzi / Trypanosoma brucei / Trypanosoma brucei brucei / Trypanocidal Agents / Leishmania infantum / Structure activity Relationship / Cell Survival / Trypanosoma brucei / Trypanosoma brucei brucei / Trypanocidal Agents / Leishmania infantum / Structure activity Relationship / Cell Survival

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Antimalarial NADPH-Consuming Redox-Cyclers as Superior G6PD Deficiency Copycats

Malaria / Oxidative Stress / Cell line / Humans / Reactive Oxygen Species / Male / Glutathione / Antimalarials / Structure activity Relationship / Erythrocytes / Male / Glutathione / Antimalarials / Structure activity Relationship / Erythrocytes

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Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors

Organic Chemistry / Animals / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Serine Protease / Molecular Structure / Serine Protease / Molecular Structure

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Zoosporicidal metabolites from an endophytic fungus Cryptosporiopsis sp. of Zanthoxylum leprieurii

Phytochemistry / Artemia / Cytotoxicity / Pythium / Biological Sciences / Animals / Cyclic peptides / CHEMICAL SCIENCES / Polyketides / Molecular Conformation / Zanthoxylum / Structure activity Relationship / Ascomycota / Plant Leaves / Animals / Cyclic peptides / CHEMICAL SCIENCES / Polyketides / Molecular Conformation / Zanthoxylum / Structure activity Relationship / Ascomycota / Plant Leaves

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