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Structure activity Relationship
Structure activity Relationship
Novel tetracyclic spiropiperidines. 3. 1-Arylspiro[indoline-3,4\'-piperidine]s as potential antidepressants
Organic Chemistry / Medicinal Chemistry / Humans / Animals / Medicinal / Structure activity Relationship / Biological Assay / Piperidines / Tetrabenazine / Structure activity Relationship / Biological Assay / Piperidines / Tetrabenazine
Imidazoles as potential antifungal agents: A review
Fungi / Humans / Antifungal Agents / Imidazoles / Structure activity Relationship
Imidazoles as potential antifungal agents: A review
Fungi / Humans / Antifungal Agents / Imidazoles / Structure activity Relationship
Antimalarial Activity of Sesquiterpene Lactones from Vernonia cinerea
Magnetic Resonance Spectroscopy / Animals / Drug Resistance / Terpenes / Sesquiterpenes / Plant extracts / Plasmodium falciparum / Antimalarials / Sensitivity and Specificity / Chloroquine / Structure activity Relationship / Lactones / Molecular Structure / Plant extracts / Plasmodium falciparum / Antimalarials / Sensitivity and Specificity / Chloroquine / Structure activity Relationship / Lactones / Molecular Structure
Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives
Organic Chemistry / Humans / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Vascular Endothelial Growth Factor
Glycogen phosphorylase: A multifaceted enzyme
Catalysis / Phosphorylation / X ray diffraction / Protein Conformation / Structure activity Relationship / Glycogen / Phosphorylases / Molecular Structure / Allosteric regulation / Glycogen / Phosphorylases / Molecular Structure / Allosteric regulation
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties
Organic Chemistry / Kinetics / Pharmaceutical Chemistry / Humans / Drug Design / Peptides / Enzyme Inhibition / Gonadotropin Releasing Hormone / Bioorganic and medicinal Chemistry / Structure activity Relationship / Ions / Molecular Structure / Peptides / Enzyme Inhibition / Gonadotropin Releasing Hormone / Bioorganic and medicinal Chemistry / Structure activity Relationship / Ions / Molecular Structure
Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2, 3-diaminopropionic acid derivatives as surrogates of aspartic acid
Organic Chemistry / Magnetic Resonance Spectroscopy / Humans / Liver / Animals / P-glycoprotein / D-Aspartic Acid / Platelet Rich Plasma / Swine / Benzoic Acid / Alkylation / Esterases / Alanine / Bioorganic and medicinal Chemistry / Structure activity Relationship / Carbamates / Benzamides / Piperidines / P-glycoprotein / D-Aspartic Acid / Platelet Rich Plasma / Swine / Benzoic Acid / Alkylation / Esterases / Alanine / Bioorganic and medicinal Chemistry / Structure activity Relationship / Carbamates / Benzamides / Piperidines
Recombinant Plasmepsin 1 from the Human Malaria Parasite Plasmodium falciparum : Enzymatic Characterization, Active Site Inhibitor Design, and Structural Analysis
Biochemistry / Catalysis / Kinetics / Enzyme Inhibitors / Humans / Animals / Structure Analysis / Solubility / Active site / Substrate Specificity / Plasmodium falciparum / Protozoan Proteins / Amino Acid Sequence / Amino Acid Substitution Rates / Structure activity Relationship / Recombinant Proteins / Hydrogen-Ion Concentration / Biochemistry and cell biology / Molecular Structure / Molecular Sequence Data / Animals / Structure Analysis / Solubility / Active site / Substrate Specificity / Plasmodium falciparum / Protozoan Proteins / Amino Acid Sequence / Amino Acid Substitution Rates / Structure activity Relationship / Recombinant Proteins / Hydrogen-Ion Concentration / Biochemistry and cell biology / Molecular Structure / Molecular Sequence Data
N, N-Dialkyl-4-[(8-Azabicyclo [3.2. 1]-Oct-3-Ylidene) Phenylmethyl] Benzamides, Potent, Selective [Delta] Opioid Agonists
Organic Chemistry / Bioorganic and medicinal Chemistry / Opioid Receptor / Structure activity Relationship / Benzamides
Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms
Kinetics / Humans / Male / Cell Fractionation / Ganoderma / High Pressure Liquid Chromatography / Tubulin / Structure activity Relationship / Protein Binding / Cell Survival / Antineoplastic Agents / Vinblastine / Triterpenes / High Pressure Liquid Chromatography / Tubulin / Structure activity Relationship / Protein Binding / Cell Survival / Antineoplastic Agents / Vinblastine / Triterpenes
Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives
Organic Chemistry / Humans / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Vascular Endothelial Growth Factor
Lanthanide nano-drums: a new class of molecular nanoparticles for potential biomedical applications
Chemical Engineering / Nanomedicine / Metal Nanoparticles / Humans / Biomedical Research / Cell Proliferation / Structure activity Relationship / Organometallic Compounds / Antineoplastic Agents / Molecular Structure / Cell Proliferation / Structure activity Relationship / Organometallic Compounds / Antineoplastic Agents / Molecular Structure
Macrólidos y cetólidos
Medical Microbiology / Drug interactions / Cerebrospinal Fluid / Pregnancy / Humans / Gram Positive / Female / Male / Microbial genetic and drug resistance / Streptococcus Pyogenes / Enzyme / Spectrum / Anti-Bacterial Agents / Bacterial infections / Community Acquired Pneumonia / Mechanism of action / Metabolic pathway / Resistance Genes Mechanism) / Structure activity Relationship / Drug Induced Liver Injury / Binding Site / Macrolides / Gram Positive / Female / Male / Microbial genetic and drug resistance / Streptococcus Pyogenes / Enzyme / Spectrum / Anti-Bacterial Agents / Bacterial infections / Community Acquired Pneumonia / Mechanism of action / Metabolic pathway / Resistance Genes Mechanism) / Structure activity Relationship / Drug Induced Liver Injury / Binding Site / Macrolides
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification
Organic Chemistry / Humans / Animals / Drug Design / Acetylcholine / Microdialysis / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Area Under Curve / Benzamides / Microdialysis / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Area Under Curve / Benzamides
2Aminomethyl piperidines as novel urotensin-II receptor antagonists
Organic Chemistry / Humans / G protein-coupled receptors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Piperidines
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