Structure activity Relationship - Page 6

A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol

Electrophysiology / Epilepsy / Multidisciplinary / Hippocampus / Mice / GABA receptors / Animals / Neurons / PLoS one / Rats / Structure activity Relationship / GABA receptor / Menthol / GABA receptors / Animals / Neurons / PLoS one / Rats / Structure activity Relationship / GABA receptor / Menthol

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Quinuclidine Derivatives as Potential Antiparasitics

Microbiology / Medical Microbiology / Animals / Enzyme / Rats / Trypanosoma Cruzi / Trypanosoma brucei / Trypanosoma brucei brucei / Plasmodium falciparum / Antimicrobial agents / Sterols / Structure activity Relationship / Recombinant Proteins / Drug Targeting / Leishmania Major / Plasma Membrane / Area of Interest / Molecular Structure / Trypanosoma Cruzi / Trypanosoma brucei / Trypanosoma brucei brucei / Plasmodium falciparum / Antimicrobial agents / Sterols / Structure activity Relationship / Recombinant Proteins / Drug Targeting / Leishmania Major / Plasma Membrane / Area of Interest / Molecular Structure

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Oxazolidinones as novel human CCR8 antagonists

Organic Chemistry / Chemokines and chemokine receptors / Humans / Computer Simulation / High throughput screening / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Oxazolidinones / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Oxazolidinones

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Mechanobiology of cartilage: how do internal and external stresses affect mechanochemical transduction and elastic energy storage?

Mechanical Engineering / Biomedical Engineering / Locomotion / Extracellular Matrix / Osteoarthritis / Elasticity / Protein Structure and Function / Humans / Collagen / Animals / Energy Storage / Articular Cartilage Wear / Energy Transfer / Structure activity Relationship / Weight Bearing / Articular Cartilage / Elasticity / Protein Structure and Function / Humans / Collagen / Animals / Energy Storage / Articular Cartilage Wear / Energy Transfer / Structure activity Relationship / Weight Bearing / Articular Cartilage

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Comparison of physico-chemical characteristics of four laccases from different basidiomycetes

Engineering / Mechanical Engineering / Chemical Engineering / Technology / Biomedical Engineering / Production / Carbon / Diet / Consumer Behavior / Scanning Electron Microscopy / Nanoparticles / Polysaccharides / Food Chemistry / Japan / Powder technology / Comparative Study / Multidisciplinary / Intention / Food Analysis / Adsorption / Commerce / Humans / Wastewater / Plant diseases / Porosity / Polyphenols / Cooking / Color / Hybrid / Copper / Food supply / Volatile Organic Compounds / Female / Animals / Disease resistance / Male / Bacteria / New Zealand / Hydrogen Production / Oryza Sativa / Taste / Anticoagulants / Laccase / Hybrids / Seaweed / Enzyme / Fermentation / Republic of Korea / Biochimie / Active site / Odors / Adult / Seeds / Thermal Stability / Particle Size / Substrate Specificity / Surface Properties / Freeze Drying / Molecular weight / Microspheres / Polyphenol / Sea Cucumbers / Structure activity Relationship / Cultivars / Ripening / Undaria / Marine Drugs / Biochemistry and cell biology / Mannitol / Anaerobic Fermentation / BASIDIOMYCOTA / Dietary fats / Pharmaceutical preparations / Production / Carbon / Diet / Consumer Behavior / Scanning Electron Microscopy / Nanoparticles / Polysaccharides / Food Chemistry / Japan / Powder technology / Comparative Study / Multidisciplinary / Intention / Food Analysis / Adsorption / Commerce / Humans / Wastewater / Plant diseases / Porosity / Polyphenols / Cooking / Color / Hybrid / Copper / Food supply / Volatile Organic Compounds / Female / Animals / Disease resistance / Male / Bacteria / New Zealand / Hydrogen Production / Oryza Sativa / Taste / Anticoagulants / Laccase / Hybrids / Seaweed / Enzyme / Fermentation / Republic of Korea / Biochimie / Active site / Odors / Adult / Seeds / Thermal Stability / Particle Size / Substrate Specificity / Surface Properties / Freeze Drying / Molecular weight / Microspheres / Polyphenol / Sea Cucumbers / Structure activity Relationship / Cultivars / Ripening / Undaria / Marine Drugs / Biochemistry and cell biology / Mannitol / Anaerobic Fermentation / BASIDIOMYCOTA / Dietary fats / Pharmaceutical preparations

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Characterization of a Dispiroketal Spirolide Subclass from Alexandrium ostenfeldii

Natural Products / Biological Sciences / Mice / Animals / Marine Toxins / CHEMICAL SCIENCES / Natural / Structure activity Relationship / Molecular Structure / CHEMICAL SCIENCES / Natural / Structure activity Relationship / Molecular Structure

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Genus Kadsura, a good source with considerable characteristic chemical constituents and potential bioactivities

Complementary and Alternative Medicine / Traditional Medicine / Plant Biology / China / Treatment Outcome / Medicinal Plants / Phytomedicine / Antioxidants / Platelet aggregation / Nitric oxide / Lignans / Kadsura / Structure activity Relationship / Antiviral Agents / Molecular Structure / Triterpenes / Neuroprotective Agents / Medicinal Plants / Phytomedicine / Antioxidants / Platelet aggregation / Nitric oxide / Lignans / Kadsura / Structure activity Relationship / Antiviral Agents / Molecular Structure / Triterpenes / Neuroprotective Agents

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Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators

Organic Chemistry / Medicinal Chemistry / Kinetics / Enzyme Inhibitors / Cell line / Humans / Mice / Animals / Drug Design / Medicinal / Neoplasms / Structure activity Relationship / Biological Availability / Antineoplastic Agents / Humans / Mice / Animals / Drug Design / Medicinal / Neoplasms / Structure activity Relationship / Biological Availability / Antineoplastic Agents

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Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

Microbiology / Medical Microbiology / Macromolecular X-Ray Crystallography / Humans / Mice / Female / Animals / Quinolones / Chagas disease / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Female / Animals / Quinolones / Chagas disease / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship

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Potent Plasmodium falciparum Gametocytocidal Activity of Diaminonaphthoquinones, Lead Antimalarial Chemotypes Identified in an Antimalarial Compound Screen

Microbiology / Medical Microbiology / Humans / Naphthoquinones / Plasmodium falciparum / Antimalarials / Imidazoles / Structure activity Relationship / Antimalarials / Imidazoles / Structure activity Relationship

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Antiviral evaluation of N-amino-1,2,3-triazoles against Cantagalo virus replication in cell culture

Organic Chemistry / Cell Culture / Cercopithecus aethiops / Cell line / Animals / European / Vaccinia Virus / Microbial Sensitivity Tests / Structure activity Relationship / X Ray Crystallography / Cell Survival / Antiviral Agents / Molecular Structure / European / Vaccinia Virus / Microbial Sensitivity Tests / Structure activity Relationship / X Ray Crystallography / Cell Survival / Antiviral Agents / Molecular Structure

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An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites

Organic Chemistry / Malaria / Humans / Drug Resistance / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Chloroquine / Structure activity Relationship / Erythrocytes / Hemoglobins / Cysteine Proteinase Inhibitors / Antimalarials / Cysteine endopeptidases / Chloroquine / Structure activity Relationship / Erythrocytes / Hemoglobins / Cysteine Proteinase Inhibitors

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Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo

Organic Chemistry / Medicinal Chemistry / Calcium / Female / Animals / Male / Myocardial Infarction / Rabbits / Structure activity Relationship / Male / Myocardial Infarction / Rabbits / Structure activity Relationship

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Dipeptidyl peptidase 8/9-like activity in human leukocytes

Immunology / Humans / Nitriles / Monoclonal Antibodies / Proline / Specific Activity / Protease Inhibitors / Molecular Conformation / Structure activity Relationship / Enzymatic Activity / Adamantane / Leukocytes / Piperidines / Specific Activity / Protease Inhibitors / Molecular Conformation / Structure activity Relationship / Enzymatic Activity / Adamantane / Leukocytes / Piperidines

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Fancy Bioisosteres: Novel Paracyclophane Derivatives As Super-Affinity Dopamine D3 Receptor Antagonists

Organic Chemistry / Medicinal Chemistry / Magnetic Resonance Spectroscopy / Dopamine / Humans / Mutation / Animals / Amides / Swine / Radioligand Assay / Medicinal / Molecular Conformation / Structure activity Relationship / Mutation / Animals / Amides / Swine / Radioligand Assay / Medicinal / Molecular Conformation / Structure activity Relationship

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The Inhaled Glucocorticoid Fluticasone Propionate Efficiently Inactivates Cytochrome P450 3A5, a Predominant Lung P450 Enzyme

Inorganic Chemistry / Organic Chemistry / Enzyme Inhibitors / Humans / Lung / Enzyme / Time Factors / Structure activity Relationship / Recombinant Proteins / Food and Chemical Toxicology / Glucocorticoids / Fluticasone propionate / Enzyme / Time Factors / Structure activity Relationship / Recombinant Proteins / Food and Chemical Toxicology / Glucocorticoids / Fluticasone propionate

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