Structure activity Relationship

Secondary amines as new pharmacophores for macrofilaricidal drug design

Organic Chemistry / Amines / Female / Animals / Male / Drug Design / Filariasis / Muridae / Structure activity Relationship / Drug Design / Filariasis / Muridae / Structure activity Relationship

Parallel Synthesis and Anti-Malarial Activity of a Sulfonamide Library

Organic Chemistry / Fluorescence Microscopy / Cell line / Humans / Plasmodium falciparum / Antimalarials / Structure activity Relationship / Antimalarials / Structure activity Relationship

Congenital Adrenal Hyperplasia due to 21Hydroxylase Deficiency

Physiology / Nursing / Kinetics / Quality of life / Pediatric nursing / Adolescent / Multidisciplinary / Screening / Cortisol / Pregnancy / Humans / Child / Mutation / Puberty / Female / Male / Disorders of sex development / Mutation Detection / Gene Conversion / Phenotype / Enzyme / Clinical Sciences / Newborn Infant / Optometry and Ophthalmology / Genotype / Adult / Congenital Adrenal Hyperplasia / Public health systems and services research / Prenatal Diagnosis / Amino Acid Sequence / Base Sequence / Structure activity Relationship / Enzymatic Activity / Glucocorticoids / Biochemistry and cell biology / Adolescent / Multidisciplinary / Screening / Cortisol / Pregnancy / Humans / Child / Mutation / Puberty / Female / Male / Disorders of sex development / Mutation Detection / Gene Conversion / Phenotype / Enzyme / Clinical Sciences / Newborn Infant / Optometry and Ophthalmology / Genotype / Adult / Congenital Adrenal Hyperplasia / Public health systems and services research / Prenatal Diagnosis / Amino Acid Sequence / Base Sequence / Structure activity Relationship / Enzymatic Activity / Glucocorticoids / Biochemistry and cell biology

EPR and O2· — scavenger activity: Cu(II)—peptide complexes as superoxide dismutase models

Inorganic Chemistry / EPR Spectroscopy / Old Copper Complex / Computer Simulation / Copper / Superoxide Dismutase / Room Temperature / Solutions / Inorganic Biochemistry / Structure activity Relationship / Superoxides / Superoxide Dismutase / Room Temperature / Solutions / Inorganic Biochemistry / Structure activity Relationship / Superoxides

In vivo active antimalarial isonitriles

Organic Chemistry / Porifera / Nitriles / Mice / Multidrug Resistance / Animals / Plasmodium falciparum / Antimalarials / Microbial Sensitivity Tests / Plasmodium yoelii / Structure activity Relationship / Animals / Plasmodium falciparum / Antimalarials / Microbial Sensitivity Tests / Plasmodium yoelii / Structure activity Relationship

Novel Conjugated Quinoline–Indoles Compromise Plasmodium falciparum Mitochondrial Function and Show Promising Antimalarial Activity

Organic Chemistry / Medicinal Chemistry / Mitochondria / Humans / Drug Resistance / Plasmodium falciparum / Antimalarials / Chloroquine / Structure activity Relationship / Hemoglobins / Plasmodium falciparum / Antimalarials / Chloroquine / Structure activity Relationship / Hemoglobins

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

Biological Sciences / Humans / Mice / Animals / Natural Product / Fishes / Anura / CHEMICAL SCIENCES / Water Microbiology / Mycobacterium Ulcerans / Structure activity Relationship / Lactones / Cytotoxins / Molecular Structure / Macrolides / Fishes / Anura / CHEMICAL SCIENCES / Water Microbiology / Mycobacterium Ulcerans / Structure activity Relationship / Lactones / Cytotoxins / Molecular Structure / Macrolides

Preparation and Pharmacological Characterization of trans -2-Amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1 H -indenes as D 2 -like Dopamine Receptor Agonists

Organic Chemistry / Medicinal Chemistry / cyclic AMP / Animals / dopamine receptor D4 / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP

Imidazolopyrazinones as potential antioxidants

Organic Chemistry / Magnetic Resonance Spectroscopy / Antioxidants / Reactive Oxygen Species / Hartree fock method / Imidazoles / Pyrazoles / Structure activity Relationship / Superoxide Anion / Superoxides / Molecular Structure / Imidazoles / Pyrazoles / Structure activity Relationship / Superoxide Anion / Superoxides / Molecular Structure

Biologically Active Dibenzofurans fromPilidiostigma glabrum, an Endemic Australian Myrtaceae

Natural Products / Australia / Macrophages / Biological Sciences / Mice / Nitric oxide / Animals / Myrtaceae / Anti-inflammatory agents / CHEMICAL SCIENCES / Anti-Bacterial Agents / Tumor necrosis factor-alpha / Structure activity Relationship / Molecular Structure / Plant Leaves / Nitric oxide / Animals / Myrtaceae / Anti-inflammatory agents / CHEMICAL SCIENCES / Anti-Bacterial Agents / Tumor necrosis factor-alpha / Structure activity Relationship / Molecular Structure / Plant Leaves

Combinatorial Engineering of Dextransucrase Specificity

Catalysis / Magnetic Resonance Spectroscopy / Multidisciplinary / Protein Engineering / Mutation / Glucans / PLoS one / Substrate Specificity / Glycosyltransferases / Amino Acid Sequence / Structure activity Relationship / Site-directed Mutagenesis / Leuconostoc / Glucans / PLoS one / Substrate Specificity / Glycosyltransferases / Amino Acid Sequence / Structure activity Relationship / Site-directed Mutagenesis / Leuconostoc

N -Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds

Pharmacology / Chemistry / Organic Chemistry / Pharmacy / Medicinal Chemistry / Malaria / Humans / Animals / Rats / Hepatocytes / Plasmodium falciparum / Antimalarials / Benzimidazoles / Structure activity Relationship / Plasmodium berghei / Malaria / Humans / Animals / Rats / Hepatocytes / Plasmodium falciparum / Antimalarials / Benzimidazoles / Structure activity Relationship / Plasmodium berghei

Design and exploratory data analysis of a second generation of dendrimer prodrugs potentially antichagasic and leishmanicide

Leishmania / Dendrimers / Prodrugs / Humans / Drug Design / Molecular Diversity / Chagas disease / Molecular Conformation / Structure activity Relationship / Molecular Structure / Molecular Diversity / Chagas disease / Molecular Conformation / Structure activity Relationship / Molecular Structure

Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist

Analytical Chemistry / Organic Chemistry / Electrophysiology / Macromolecular X-Ray Crystallography / Chirality / Glutamate receptors / Female / Animals / Propionic Acid / Resolution / High Pressure Liquid Chromatography / Molecular cloning / Rats / Radioligand Assay / Xenopus laevis / Protein Conformation / Chiral HPLC / Alanine / Oocytes / Structure activity Relationship / Recombinant Proteins / X Ray Crystallography / Molecular Structure / Glutamate Receptor / Glutamate receptors / Female / Animals / Propionic Acid / Resolution / High Pressure Liquid Chromatography / Molecular cloning / Rats / Radioligand Assay / Xenopus laevis / Protein Conformation / Chiral HPLC / Alanine / Oocytes / Structure activity Relationship / Recombinant Proteins / X Ray Crystallography / Molecular Structure / Glutamate Receptor

Leishmanicidal activity of amino acid and peptide esters: an update

Medical Microbiology / Leishmania / Biological Sciences / Leishmaniasis / Mice / Animals / Amino Acid Profile / Structure activity Relationship / Animals / Amino Acid Profile / Structure activity Relationship

Efficient approach to novel 1α-triazolyl-5α-androstane derivatives as potent antiproliferative agents

Organic Chemistry / Humans / Cell Proliferation / Structure activity Relationship / Molecular Structure

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