Structure activity Relationship - Page 4

4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as Potential Pharmacological Agents

Organic Chemistry / Crystal structure / Humans / Molecules / Structure activity Relationship / Alkanes / Cell Survival / Alcohols / Alkanes / Cell Survival / Alcohols

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2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 2

Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents

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2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 1

Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents

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Peptide stability in drug development: A comparison of peptide reactivity in different biological media

Rheumatoid Arthritis / Drug development / Pharmaceutical Chemistry / Humans / Liver / Mice / Pharmaceutical Sciences / Animals / Peptides / Cattle / Shell Half-Life / Molecular weight / Amino Acid Sequence / Structure activity Relationship / Drug Stability / Synovial-fluid / Mice / Pharmaceutical Sciences / Animals / Peptides / Cattle / Shell Half-Life / Molecular weight / Amino Acid Sequence / Structure activity Relationship / Drug Stability / Synovial-fluid

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Peptide stability in drug development: A comparison of peptide reactivity in different biological media

Rheumatoid Arthritis / Drug development / Pharmaceutical Chemistry / Humans / Liver / Mice / Pharmaceutical Sciences / Animals / Peptides / Cattle / Shell Half-Life / Molecular weight / Amino Acid Sequence / Structure activity Relationship / Drug Stability / Synovial-fluid / Mice / Pharmaceutical Sciences / Animals / Peptides / Cattle / Shell Half-Life / Molecular weight / Amino Acid Sequence / Structure activity Relationship / Drug Stability / Synovial-fluid

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Antiviral evaluation of N-amino-1,2,3-triazoles against Cantagalo virus replication in cell culture

Organic Chemistry / Cell Culture / Cercopithecus aethiops / Cell line / Animals / European / Vaccinia Virus / Microbial Sensitivity Tests / Structure activity Relationship / X Ray Crystallography / Cell Survival / Antiviral Agents / Molecular Structure / European / Vaccinia Virus / Microbial Sensitivity Tests / Structure activity Relationship / X Ray Crystallography / Cell Survival / Antiviral Agents / Molecular Structure

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Branched Diacylglycerol-Lactones as Potent Protein Kinase C Ligands and α-Secretase Activators

Organic Chemistry / Medicinal Chemistry / Humans / Animals / Rats / Structure activity Relationship / Protein Binding / Diglycerides / Ligands / Lactones / Structure activity Relationship / Protein Binding / Diglycerides / Ligands / Lactones

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2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 2

Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents

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2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 1

Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents

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Leflunomide analogues as potential antiinflammatory agents

Treatment / Inflammation / Mice / Animals / Male / Rats / Edema / Structure activity Relationship / Chemical Synthesis / Rats / Edema / Structure activity Relationship / Chemical Synthesis

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Leflunomide Analogues as Potential Antiinflammatory Agents

Treatment / Inflammation / Mice / Animals / Male / Rats / Edema / Structure activity Relationship / Chemical Synthesis / Rats / Edema / Structure activity Relationship / Chemical Synthesis

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Biophysical characterization of a recombinant leucyl aminopeptidase from Bacillus kaustophilus

Biochemistry / Thermodynamics / Dentistry / Structural Biology / Molecular Dynamics Simulation / Genomics / Protein Folding / Proteomics / Biological Physics / Fluorescent Dyes and Reagents / Apoptosis / Structural Genomics / Ion Channels / Macromolecular X-Ray Crystallography / Protein Stability / HIV / Neurospora crassa / Cell line / Humans / Sequence alignment / Computer Simulation / Circular Dichroism / Mice / Animals / Bacillus / Ligand Binding / Temperature / Urea / Enzyme / Molecular cloning / Amino Acids / Protein Sequence Analysis / Cell nucleus / Anti-Bacterial Agents / Protein Secondary Structure Prediction / Success Rate / Spectrum analysis / Trifluoroethanol / Transfection / Protein Conformation / Molecular weight / Large Scale / Amino Acid Sequence / Calcium Chloride / Protein Quaternary Structure / Recombinant Protein / Structure activity Relationship / Recombinant Proteins / Protein Binding / Hydrogen-Ion Concentration / X Ray Crystallography / Structure Determination / Protein Denaturation / Ligands / Sodium Chloride / Biochemistry and cell biology / Solvents / Genomics / Protein Folding / Proteomics / Biological Physics / Fluorescent Dyes and Reagents / Apoptosis / Structural Genomics / Ion Channels / Macromolecular X-Ray Crystallography / Protein Stability / HIV / Neurospora crassa / Cell line / Humans / Sequence alignment / Computer Simulation / Circular Dichroism / Mice / Animals / Bacillus / Ligand Binding / Temperature / Urea / Enzyme / Molecular cloning / Amino Acids / Protein Sequence Analysis / Cell nucleus / Anti-Bacterial Agents / Protein Secondary Structure Prediction / Success Rate / Spectrum analysis / Trifluoroethanol / Transfection / Protein Conformation / Molecular weight / Large Scale / Amino Acid Sequence / Calcium Chloride / Protein Quaternary Structure / Recombinant Protein / Structure activity Relationship / Recombinant Proteins / Protein Binding / Hydrogen-Ion Concentration / X Ray Crystallography / Structure Determination / Protein Denaturation / Ligands / Sodium Chloride / Biochemistry and cell biology / Solvents

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Extended sequence preferences for oligodeoxyribonucleotide activity

Immunology / Apoptosis / Toll like receptor signaling / Mice / Female / Animals / CpG islands / NF-kappa B / B Lymphocytes / Base Sequence / Structure activity Relationship / DNA binding proteins / Interleukin / Animals / CpG islands / NF-kappa B / B Lymphocytes / Base Sequence / Structure activity Relationship / DNA binding proteins / Interleukin

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Quinuclidine Derivatives as Potential Antiparasitics

Microbiology / Medical Microbiology / Animals / Enzyme / Rats / Trypanosoma Cruzi / Trypanosoma brucei / Trypanosoma brucei brucei / Plasmodium falciparum / Antimicrobial agents / Sterols / Structure activity Relationship / Recombinant Proteins / Drug Targeting / Leishmania Major / Plasma Membrane / Area of Interest / Molecular Structure / Trypanosoma Cruzi / Trypanosoma brucei / Trypanosoma brucei brucei / Plasmodium falciparum / Antimicrobial agents / Sterols / Structure activity Relationship / Recombinant Proteins / Drug Targeting / Leishmania Major / Plasma Membrane / Area of Interest / Molecular Structure

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Guanidino Acids Act as ρ1 GABAC Receptor Antagonists

Biological Sciences / Humans / Circadian Rhythm / GABA receptors / Female / Animals / Nitrogen / Xenopus laevis / Taurine / Glycine / Guanidines / Oocytes / Structure activity Relationship / Voltage Clamp / Recombinant Proteins / Neurochemical / Animals / Nitrogen / Xenopus laevis / Taurine / Glycine / Guanidines / Oocytes / Structure activity Relationship / Voltage Clamp / Recombinant Proteins / Neurochemical

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High-density mutagenesis by combined DNA shuffling and phage display to assign essential amino acid residues in protein-protein interactions: application to study structure-function of plasminogen activation inhibitor 1 (PAI-I)

Molecular Biology / Recombinant DNA Technology / Protein-Protein Interaction / Humans / Mutagenesis / Sequence alignment / Mice / Animals / Epitope mapping / Phage display / Surface plasmon resonance / Monoclonal Antibodies / Shell Half-Life / Molecular cloning / Surface Area / Amino Acid Profile / High Density Concrete / Monoclonal Antibody / Tissue Plasminogen Activator / Amino Acid Substitution Rates / Structure activity Relationship / Protein Binding / D structure / Structure Function / Epitopes / Plasminogen Activator Inhibitor / Biochemistry and cell biology / Sequence alignment / Mice / Animals / Epitope mapping / Phage display / Surface plasmon resonance / Monoclonal Antibodies / Shell Half-Life / Molecular cloning / Surface Area / Amino Acid Profile / High Density Concrete / Monoclonal Antibody / Tissue Plasminogen Activator / Amino Acid Substitution Rates / Structure activity Relationship / Protein Binding / D structure / Structure Function / Epitopes / Plasminogen Activator Inhibitor / Biochemistry and cell biology

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