Oxazolidinones as novel human CCR8 antagonists

2007

Receptor binding activity X 0280 Oxazolidinones as Novel Human CCR8 Antagonists. — High-throughput screenof the corporate compound collection identifies a series of N-substituted-5-aryl30- 195 ing -oxazolidinones as potent CCR8 antagonists. Overall, antagonist (I) shows good chemotaxis activity, selectivity vs. a number of 7TM receptors, and hERG properties. — (JIN*, J.; et al.; Bioorg. Med. Chem. Lett. 17 (2007) 6, 1722-1725; Dep. Med. Chem., GlaxoSmithKline Pharm., Collegeville, PA 19426, USA; Eng.) — H. Hoennerscheid