Enzyme Inhibitors

Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli

Enzyme Inhibitors / Biological Sciences / Humans / Protein Kinases / Escherichia coli / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure

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Alpha Interferon Induces Distinct Translational Control Programs To Suppress Hepatitis C Virus RNA Replication

Virology / Enzyme Inhibitors / Protein Stability / Biological Sciences / Cell line / Humans / Hepatitis C Virus / Protein Kinase R / Base Sequence / Recombinant Proteins / Translational Control / Drug Stability / Translation initiation / Internal ribosome entry site / Protein Biosynthesis / Interferon Alpha / Polyribosomes / Humans / Hepatitis C Virus / Protein Kinase R / Base Sequence / Recombinant Proteins / Translational Control / Drug Stability / Translation initiation / Internal ribosome entry site / Protein Biosynthesis / Interferon Alpha / Polyribosomes

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Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells

Kinetics / Immunohistochemistry / Enzyme Inhibitors / Western blotting / Glucose / Insulin Secretion / Animals / Peptides / Food intake / Sodium / Swine / Venoms / Insulin Secretion / Animals / Peptides / Food intake / Sodium / Swine / Venoms

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Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8

Psychology / Cognitive Science / Calcium / Drug interactions / Enzyme Inhibitors / Patch-clamp and imaging techniques / Cell line / Humans / Mutagenesis / Transient receptor potential channels / Animals / Rats / Time Factors / Transfection / Neurosciences / Fura / Menthol / Patch-clamp and imaging techniques / Cell line / Humans / Mutagenesis / Transient receptor potential channels / Animals / Rats / Time Factors / Transfection / Neurosciences / Fura / Menthol

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Enhancement of a pentacyclic tyrosine kinase inhibitor production in Cladosporium cf. cladosporioides by Cladosporol

Enzyme Inhibitors / Multidisciplinary / Applied Microbiology and Biotechnology / Tyrosine Kinase Inhibitor / Biotransformation / Chromones / Molecular Structure / Cladosporium / Chromones / Molecular Structure / Cladosporium

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Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities

Organic Chemistry / Enzyme Inhibitors / Mice / Animals / Male / Drug Design / Polycyclic aromatic hydrocarbons (PAHs) / lipoxygenase (LOX) inhibitors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bone Marrow Cells / Drug Design / Polycyclic aromatic hydrocarbons (PAHs) / lipoxygenase (LOX) inhibitors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bone Marrow Cells

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Propecia-induced spermatogenic failure: a report of two cases

Enzyme Inhibitors / Humans / Fertility and Sterility / Male / Azoospermia / Clinical Sciences / Adult / Public health systems and services research / Finasteride / Clinical Sciences / Adult / Public health systems and services research / Finasteride

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Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms

Enzyme Inhibitors / DNA damage / DNA repair / Biological Sciences / Archaea / Sulfolobus / Hydrolysis / Hot Temperature / Sulfolobus / Hydrolysis / Hot Temperature

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Enhancement of a pentacyclic tyrosine kinase inhibitor production in Cladosporium cf. cladosporioides by Cladosporol

Enzyme Inhibitors / Multidisciplinary / Applied Microbiology and Biotechnology / Tyrosine Kinase Inhibitor / Biotransformation / Chromones / Molecular Structure / Cladosporium / Chromones / Molecular Structure / Cladosporium

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PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy

Immunohistochemistry / Enzyme Inhibitors / Type 2 Diabetes / Free Radical / Neuropathic pain / Mice / Animals / Male / Drinking Water / Skin / Diabetic Neuropathy / Mouse Model / Rats / Degeneration / Peripheral nerves / Peripheral Nerve / Wistar Rats / Combination drug therapy / Streptozotocin / Diabetic Rat / Organic Chemicals / Biochemistry and cell biology / Mice / Animals / Male / Drinking Water / Skin / Diabetic Neuropathy / Mouse Model / Rats / Degeneration / Peripheral nerves / Peripheral Nerve / Wistar Rats / Combination drug therapy / Streptozotocin / Diabetic Rat / Organic Chemicals / Biochemistry and cell biology

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Muscarinic acetylcholine receptor activation induces Ca2+ mobilization and Na+/K+-ATPase activity inhibition in eel enterocytes

Endocrinology / Calcium / Enzyme Inhibitors / Animal Production / Tacrolimus / Animals / EELS / Clinical Sciences / Sodium / Analysis of Variance / Veterinary Sciences / Calcineurin inhibitors / Nifedipine / Sirolimus / Enterocytes / Calcium Channel Blockers / Animals / EELS / Clinical Sciences / Sodium / Analysis of Variance / Veterinary Sciences / Calcineurin inhibitors / Nifedipine / Sirolimus / Enterocytes / Calcium Channel Blockers

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Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson\'s disease

Neurobiology Of Disease / Drug interactions / Enzyme Inhibitors / Transmission Electron Microscopy / Neurobiology / Cell Differentiation / Humans / Endoplasmic Reticulum / Tunicamycin / ER stress / Neurons / Human Brain / Enzyme / Clinical Sciences / Neuroblastoma / Cellular Automaton Model / Degeneration / Retinoic Acid / Tretinoin / Membrane Protein / Enzymatic Activity / Cytoplasm / Neurosciences / Transglutaminases / Cell Differentiation / Humans / Endoplasmic Reticulum / Tunicamycin / ER stress / Neurons / Human Brain / Enzyme / Clinical Sciences / Neuroblastoma / Cellular Automaton Model / Degeneration / Retinoic Acid / Tretinoin / Membrane Protein / Enzymatic Activity / Cytoplasm / Neurosciences / Transglutaminases

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Functional Expression of NAD(P)H Oxidase p47 in Lung Microvascular Endothelial Cells

Microcirculation / Enzyme Inhibitors / Signal Transduction / Humans / Mice / Nitric oxide / Animals / Vascular endothelium / NADPH oxidase / Endothelial cell / Intracellular Signaling / Allopurinol / Phorbol ester / Superoxides / Biochemistry and cell biology / Indomethacin / Pulmonary circulation / Nitric oxide / Animals / Vascular endothelium / NADPH oxidase / Endothelial cell / Intracellular Signaling / Allopurinol / Phorbol ester / Superoxides / Biochemistry and cell biology / Indomethacin / Pulmonary circulation

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Viral and cellular kinases are potential antiviral targets and have a central role in varicella zoster virus pathogenesis

Cell Cycle / Enzyme Inhibitors / Biological Sciences / Cell line / Humans / Cytomegalovirus / Physical sciences / Kinase inhibitor / Cdk / Antiviral Activity / Antiviral Agents / Varicella Zoster Virus / Cytomegalovirus / Physical sciences / Kinase inhibitor / Cdk / Antiviral Activity / Antiviral Agents / Varicella Zoster Virus

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PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis1

Enzyme Inhibitors / Extracellular Matrix / Cell Division / Signal Transduction / Cell line / Smooth muscle / Kidney / Collagen / Animals / Male / Fibroblast Growth Factor / Clinical Sciences / Rats / Wistar Rats / Cell Proliferation / Growth Factor / Renal disease / Benzamides / Receptor Tyrosine Kinase / Smooth muscle / Kidney / Collagen / Animals / Male / Fibroblast Growth Factor / Clinical Sciences / Rats / Wistar Rats / Cell Proliferation / Growth Factor / Renal disease / Benzamides / Receptor Tyrosine Kinase

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PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy

Immunohistochemistry / Enzyme Inhibitors / Type 2 Diabetes / Free Radical / Neuropathic pain / Mice / Animals / Male / Drinking Water / Skin / Diabetic Neuropathy / Mouse Model / Rats / Degeneration / Peripheral nerves / Peripheral Nerve / Wistar Rats / Combination drug therapy / Streptozotocin / Diabetic Rat / Organic Chemicals / Biochemistry and cell biology / Mice / Animals / Male / Drinking Water / Skin / Diabetic Neuropathy / Mouse Model / Rats / Degeneration / Peripheral nerves / Peripheral Nerve / Wistar Rats / Combination drug therapy / Streptozotocin / Diabetic Rat / Organic Chemicals / Biochemistry and cell biology

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Kinetics / Immunohistochemistry / Enzyme Inhibitors / Western blotting / Glucose / Insulin Secretion / Animals / Peptides / Food intake / Sodium / Swine / Venoms / Insulin Secretion / Animals / Peptides / Food intake / Sodium / Swine / Venoms

Enzyme Inhibitors / Multidisciplinary / Applied Microbiology and Biotechnology / Tyrosine Kinase Inhibitor / Biotransformation / Chromones / Molecular Structure / Cladosporium / Chromones / Molecular Structure / Cladosporium

Enzyme Inhibitors / Humans / Fertility and Sterility / Male / Azoospermia / Clinical Sciences / Adult / Public health systems and services research / Finasteride / Clinical Sciences / Adult / Public health systems and services research / Finasteride

Enzyme Inhibitors / DNA damage / DNA repair / Biological Sciences / Archaea / Sulfolobus / Hydrolysis / *Hot Temperature / Sulfolobus / Hydrolysis / *Hot Temperature

Enzyme Inhibitors / Multidisciplinary / Applied Microbiology and Biotechnology / Tyrosine Kinase Inhibitor / Biotransformation / Chromones / Molecular Structure / Cladosporium / Chromones / Molecular Structure / Cladosporium

Enzyme Inhibitors / DNA damage / DNA repair / Biological Sciences / Archaea / Sulfolobus / Hydrolysis / Hot Temperature / Sulfolobus / Hydrolysis / Hot Temperature