Macromolecular X-Ray Crystallography - Page 5

Structural Analysis of a Putative Aminoglycoside N-Acetyltransferase from Bacillus anthracis

Thermodynamics / Molecular Biology / Protein Folding / Macromolecular X-Ray Crystallography / Molecular / Humans / Mutation / Escherichia coli / Protein structure / Structure Analysis / Anthrax / Anti-Bacterial Agents / Protein Secondary Structure Prediction / Bacillus subtilis / Substrate Specificity / Amino Acid Sequence / Resistance Genes Mechanism) / Bacillus Anthracis / Lethal Factor / Protein Binding / Protein Data Bank / Biochemistry and cell biology / Humans / Mutation / Escherichia coli / Protein structure / Structure Analysis / Anthrax / Anti-Bacterial Agents / Protein Secondary Structure Prediction / Bacillus subtilis / Substrate Specificity / Amino Acid Sequence / Resistance Genes Mechanism) / Bacillus Anthracis / Lethal Factor / Protein Binding / Protein Data Bank / Biochemistry and cell biology

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Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Dogs / Humans / Blood brain barrier / Animals / Drug Design / Rats / Pyrazoles / Structure activity Relationship / cyclic GMP / Molecular Structure / Blood brain barrier / Animals / Drug Design / Rats / Pyrazoles / Structure activity Relationship / cyclic GMP / Molecular Structure

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Arabidopsis Chloroplastic Glutaredoxin C5 as a Model to Explore Molecular Determinants for Iron-Sulfur Cluster Binding into Glutaredoxins

Biological Chemistry / Macromolecular X-Ray Crystallography / Biological Sciences / Biological / Arabidopsis / CHEMICAL SCIENCES / Molecular cloning / Liquid Chromatography / Electrospray Ionization Mass Spectrometry / Subcellular Fractions / Protein Binding / Chloroplasts / CHEMICAL SCIENCES / Molecular cloning / Liquid Chromatography / Electrospray Ionization Mass Spectrometry / Subcellular Fractions / Protein Binding / Chloroplasts

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Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase

Analytical Chemistry / Fluorescence / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Fluorescence Resonance Energy Transfer / Humans / Tryptophan / Solubility / Analytical Biochemistry / Biological Assay / Biochemistry and cell biology / Humans / Tryptophan / Solubility / Analytical Biochemistry / Biological Assay / Biochemistry and cell biology

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Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1 H-pyrrolo[1,2- c]imidazol-1-ones: A new class of Neuropeptide S antagonists

Inorganic Chemistry / Organic Chemistry / Medicinal Chemistry / Calcium / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure

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Different intermolecular interactions in azido[2-(diphenylphosphino)benzaldehyde semicarbazonato-kappa2P,N1,O]nickel(II)

Inorganic Chemistry / Macromolecular X-Ray Crystallography / Nickel / Hydrogen Bonding / Organometallic Compounds / Intermolecular Interaction / Ligands / Molecular Structure / Intermolecular Interaction / Ligands / Molecular Structure

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Are proteins ideal mixtures of amino acids? Analysis of energy parameter sets

Mathematics / Thermodynamics / Protein Folding / Protein Science / Magnetic Resonance Spectroscopy / Macromolecular X-Ray Crystallography / Protein structure / Proteins / Free Energy / Amino Acids / Amino Acid Profile / Correlation coefficient / Protein Conformation / Amino Acid Sequence / Low Resolution / Biochemistry and cell biology / Macromolecular X-Ray Crystallography / Protein structure / Proteins / Free Energy / Amino Acids / Amino Acid Profile / Correlation coefficient / Protein Conformation / Amino Acid Sequence / Low Resolution / Biochemistry and cell biology

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Amino acid preferences at protein binding sites

Macromolecular X-Ray Crystallography / Enzymes / Proteins / Amino Acids / Amino Acid Profile / Protein Conformation / Structure activity Relationship / Protein Binding / Ligands / Biochemistry and cell biology / Protein Conformation / Structure activity Relationship / Protein Binding / Ligands / Biochemistry and cell biology

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Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates

Multidisciplinary / Macromolecular X-Ray Crystallography / Bacillus megaterium / Propranolol / Amino Acid Substitution Rates

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The Escherichia coli YadB Gene Product Reveals a Novel Aminoacyl-tRNA Synthetase Like Activity

Molecular Biology / Kinetics / Structural Genomics / Macromolecular X-Ray Crystallography / Molecular / Glutamate / Escherichia coli / Zinc / Amino Acid Profile / Protein Conformation / Amino Acid Sequence / Open Reading Frame / Gene Family / aminoacyl-tRNA synthetase / Molecular Replacement / Ligands / Glutamic Acid / Biochemistry and cell biology / Adenosine Triphosphate / Adenosine monophosphate / Glutamate / Escherichia coli / Zinc / Amino Acid Profile / Protein Conformation / Amino Acid Sequence / Open Reading Frame / Gene Family / aminoacyl-tRNA synthetase / Molecular Replacement / Ligands / Glutamic Acid / Biochemistry and cell biology / Adenosine Triphosphate / Adenosine monophosphate

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Anthracene–BODIPY Cassettes: Syntheses and Energy Transfer

Chemistry / Fluorescent Dyes and Reagents / Macromolecular X-Ray Crystallography / CHEMICAL SCIENCES / Energy Transfer / Boron Compounds / Oxidation-Reduction / Molecular Structure / Boron Compounds / Oxidation-Reduction / Molecular Structure

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Structural Characterization of a Putative Endogenous Metal Chelator in the Periplasmic Nickel Transporter NikA † ‡

Biochemistry / Macromolecular X-Ray Crystallography / Nickel / Protein Secondary Structure Prediction / Chelating Agents / Biochemistry and cell biology

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Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes

Small angle X-ray and neutron scattering / Multidisciplinary / Macromolecular X-Ray Crystallography / Amyotrophic Lateral Sclerosis / Humans / Mutation / Copper / Superoxide Dismutase / Phenotype / Solutions / Acids / Edetic Acid / Mutation / Copper / Superoxide Dismutase / Phenotype / Solutions / Acids / Edetic Acid

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Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes

Small angle X-ray and neutron scattering / Multidisciplinary / Macromolecular X-Ray Crystallography / Amyotrophic Lateral Sclerosis / Humans / Mutation / Copper / Superoxide Dismutase / Phenotype / Solutions / Acids / Edetic Acid / Mutation / Copper / Superoxide Dismutase / Phenotype / Solutions / Acids / Edetic Acid

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Multicomponent pharmaceutical cocrystals: furosemide and pentoxifylline

Inorganic Chemistry / Macromolecular X-Ray Crystallography / Hydrogen Bonding / Furosemide / Molecular Structure / Pentoxifylline

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Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase

Molecular Dynamics Simulation / Kinetics / Biological Chemistry / Macromolecular X-Ray Crystallography / Biological Sciences / Mutation / CHEMICAL SCIENCES / Protein Secondary Structure Prediction / Protein Binding / Nucleotides / Poliovirus / Mutation / CHEMICAL SCIENCES / Protein Secondary Structure Prediction / Protein Binding / Nucleotides / Poliovirus

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