Macromolecular X-Ray Crystallography

Biochemical Properties and Crystal Structure of a -Phenylalanine Aminotransferase from Variovorax paradoxus

Multidisciplinary / Macromolecular X-Ray Crystallography / Escherichia coli / Applied Environmental Microbiology / Temperature / Molecular cloning / Phenylalanine / Substrate Specificity / Protein Conformation / Molecular weight / Amino Acid Sequence / Recombinant Proteins / Transaminases / Molecular cloning / Phenylalanine / Substrate Specificity / Protein Conformation / Molecular weight / Amino Acid Sequence / Recombinant Proteins / Transaminases

Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase

Molecular Dynamics Simulation / Kinetics / Biological Chemistry / Macromolecular X-Ray Crystallography / Biological Sciences / Mutation / CHEMICAL SCIENCES / Protein Secondary Structure Prediction / Protein Binding / Nucleotides / Poliovirus / Mutation / CHEMICAL SCIENCES / Protein Secondary Structure Prediction / Protein Binding / Nucleotides / Poliovirus

Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist

Analytical Chemistry / Organic Chemistry / Electrophysiology / Macromolecular X-Ray Crystallography / Chirality / Glutamate receptors / Female / Animals / Propionic Acid / High Pressure Liquid Chromatography / Molecular cloning / Rats / Radioligand Assay / Xenopus laevis / Protein Conformation / Alanine / Oocytes / Structure activity Relationship / Recombinant Proteins / Molecular Structure / Glutamate receptors / Female / Animals / Propionic Acid / High Pressure Liquid Chromatography / Molecular cloning / Rats / Radioligand Assay / Xenopus laevis / Protein Conformation / Alanine / Oocytes / Structure activity Relationship / Recombinant Proteins / Molecular Structure

Khayanolides from African mahogany Khaya senegalensis (Meliaceae): A revision

Phytochemistry / Africa / Magnetic Resonance Spectroscopy / Macromolecular X-Ray Crystallography / Biological Sciences / Meliaceae / CHEMICAL SCIENCES / X ray diffraction / Single Crystal / Furans / Molecular Structure / Meliaceae / CHEMICAL SCIENCES / X ray diffraction / Single Crystal / Furans / Molecular Structure

Paramecium bursaria Chlorella Virus 1 Encodes a Polyamine Acetyltransferase

Kinetics / Biological Chemistry / Macromolecular X-Ray Crystallography / Polyamines / Biological Sciences / CHEMICAL SCIENCES / Histones / CHEMICAL SCIENCES / Histones

A Structural Model of Transcription Elongation

Science / RNA polymerase / Gene expression / Multidisciplinary / Macromolecular X-Ray Crystallography / Transcription / DNA / Mutation / Nucleic acid hybridization / Bacteria / DNA hybridization / Mechanism / Elongation / Enzyme activity / Protein Conformation / Crystalline Structure / Nucleic Acid Conformation / Structural model / Nucleic Acid / single stranded DNA / Functional Properties / Transcription / DNA / Mutation / Nucleic acid hybridization / Bacteria / DNA hybridization / Mechanism / Elongation / Enzyme activity / Protein Conformation / Crystalline Structure / Nucleic Acid Conformation / Structural model / Nucleic Acid / single stranded DNA / Functional Properties

Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution

Multidisciplinary / Macromolecular X-Ray Crystallography / Humans / Sequence alignment / Schizosaccharomyces Pombe / Amino Acid Sequence

A T Cell Receptor Goes Public

Structure / Macromolecular X-Ray Crystallography / Biological Sciences / Humans / Peptides / CHEMICAL SCIENCES / Protein Conformation / Ligands / Dimerization / CHEMICAL SCIENCES / Protein Conformation / Ligands / Dimerization

Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Humans / Kinase inhibitor / Hydrogen Bond / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Alkynes / Molecular Structure / Receptor Tyrosine Kinase / Hydrogen Bond / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Alkynes / Molecular Structure / Receptor Tyrosine Kinase

Crystal Structure of the Pregnane X Receptor-Estradiol Complex Provides Insights into Endobiotic Recognition

Molecular endocrinology / Macromolecular X-Ray Crystallography / Estrogen Receptor / Nuclear Receptor / Biological Sciences / Molecular / Crystal structure / Humans / Mutagenesis / Animals / Amino Acids / Protein Conformation / Amino Acid Sequence / Estradiol / Pregnane X Receptor / Estrogen receptor alpha / Molecular / Crystal structure / Humans / Mutagenesis / Animals / Amino Acids / Protein Conformation / Amino Acid Sequence / Estradiol / Pregnane X Receptor / Estrogen receptor alpha

A carboxylato-supported alkoxo-bridged dimanganese(III) complex: bis(mu-benzoato-O:O\')bis[3-(33-methoxysalicydeneamino)propanolato-O,N,O\':O\']dimanganese(III)

Inorganic Chemistry / Manganese / Macromolecular X-Ray Crystallography / Crystal structure / Enzymes / XRD / Molecular Mimicry / Ether / Organometallic Compounds / Molecular Structure / XRD / Molecular Mimicry / Ether / Organometallic Compounds / Molecular Structure

Discovery of 5-[[4-[(2,3-Dimethyl-2 H -indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor †

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Humans / Cancer Therapy / Mice / Animals / Isoenzymes / Medicinal / Neoplasms / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Vascular endothelial growth factor receptor / Mice / Animals / Isoenzymes / Medicinal / Neoplasms / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Vascular endothelial growth factor receptor

An Iron Nitride Complex

Macromolecular X-Ray Crystallography / CHEMICAL SCIENCES / Electrons / Spectrum analysis / NITRIC ACID / Iron Compounds / Molecular Structure / Iron Compounds / Molecular Structure

Degenerate interfaces in antigen-antibody complexes

Molecular Biology / Macromolecular X-Ray Crystallography / Female / Animals / Camels / Chickens / Degeneration / Protein Conformation / Egg White / Biochemistry and cell biology / Chickens / Degeneration / Protein Conformation / Egg White / Biochemistry and cell biology

UPLC-MS-ELSD-PDA as a Powerful Dereplication Tool to Facilitate Compound Identification from Small-Molecule Natural Product Libraries

Natural Products / Mass Spectrometry / Macromolecular X-Ray Crystallography / Biological Sciences / Arizona / CHEMICAL SCIENCES / Diterpenes / Molecular Conformation / Flavones / Hesperidin / Molecular Structure / Plant Leaves / CHEMICAL SCIENCES / Diterpenes / Molecular Conformation / Flavones / Hesperidin / Molecular Structure / Plant Leaves

MultiBac complexomics

Macromolecular X-Ray Crystallography / Western blotting / Genetic Engineering / Escherichia coli / Animals / Plasmids / Glycoproteins / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Molecular cloning / Recombinant Proteins / Biochemistry and cell biology / Plasmids / Glycoproteins / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Molecular cloning / Recombinant Proteins / Biochemistry and cell biology

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