Bioorganic and medicinal Chemistry - Page 5

Peptide chemical ligation inside living cells: in vivo generation of a circular protein domain

Organic Chemistry / Mass Spectrometry / Protein Engineering / Escherichia coli / Mice / Animals / Magnetic Resonance / Cyclic peptides / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / High Pressure Liquid Chromatography / Protein Domains / Liquid Chromatography / Quantum correlations / Cyclization / Amino Acid Profile / Bioorganic and medicinal Chemistry / Biological activity / Protein Binding / Animals / Magnetic Resonance / Cyclic peptides / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / High Pressure Liquid Chromatography / Protein Domains / Liquid Chromatography / Quantum correlations / Cyclization / Amino Acid Profile / Bioorganic and medicinal Chemistry / Biological activity / Protein Binding

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Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1 H-pyrrolo[1,2- c]imidazol-1-ones: A new class of Neuropeptide S antagonists

Inorganic Chemistry / Organic Chemistry / Medicinal Chemistry / Calcium / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure

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N-Amino acid linoleoyl conjugates: Anti-inflammatory activities

Organic Chemistry / Macrophages / Cell line / Mice / Animals / Amino Acids / Bioorganic and medicinal Chemistry / Structure activity Relationship / Linoleic Acid / Molecular Structure / Amino Acids / Bioorganic and medicinal Chemistry / Structure activity Relationship / Linoleic Acid / Molecular Structure

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3D-QSAR design of novel antiepileptic sulfamides

Organic Chemistry / Epilepsy / Mice / Female / Animals / Male / Drug Design / Quantitative Structure Activity Relationship / Three Dimensional / Bioorganic and medicinal Chemistry / Structure activity Relationship / Ligands / Molecular Structure / Male / Drug Design / Quantitative Structure Activity Relationship / Three Dimensional / Bioorganic and medicinal Chemistry / Structure activity Relationship / Ligands / Molecular Structure

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Squaric acid derivatives as VLA-4 integrin antagonists

Organic Chemistry / Amines / Animals / Integrins / Rats / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship

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Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines

Organic Chemistry / Drug development / Cell line / Tuberculosis / Humans / Mycobacterium tuberculosis / Developing Country / Infectious Disease / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry / Mycobacterium tuberculosis / Developing Country / Infectious Disease / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry

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Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities

Organic Chemistry / Enzyme Inhibitors / Mice / Animals / Male / Drug Design / Polycyclic aromatic hydrocarbons (PAHs) / lipoxygenase (LOX) inhibitors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bone Marrow Cells / Drug Design / Polycyclic aromatic hydrocarbons (PAHs) / lipoxygenase (LOX) inhibitors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bone Marrow Cells

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Author\'s personal copy Diamination by N-coupling using a commercial laccase

Organic Chemistry / Bioorganic and medicinal Chemistry

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Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists

Organic Chemistry / Humans / Propionic Acid / Alanine / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Biological Availability / Structure activity Relationship / Protein Binding / Biological Availability

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Peptide chemical ligation inside living cells: in vivo generation of a circular protein domain

Organic Chemistry / Mass Spectrometry / Protein Engineering / Escherichia coli / Mice / Animals / Magnetic Resonance / Cyclic peptides / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / High Pressure Liquid Chromatography / Protein Domains / Liquid Chromatography / Quantum correlations / Cyclization / Amino Acid Profile / Bioorganic and medicinal Chemistry / Biological activity / Protein Binding / Animals / Magnetic Resonance / Cyclic peptides / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / High Pressure Liquid Chromatography / Protein Domains / Liquid Chromatography / Quantum correlations / Cyclization / Amino Acid Profile / Bioorganic and medicinal Chemistry / Biological activity / Protein Binding

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4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists

Organic Chemistry / Bioorganic and medicinal Chemistry

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2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists

Organic Chemistry / Physical Chemistry / Humans / Drug Design / Bioorganic and medicinal Chemistry / Structure activity Relationship

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2-Arylpyrimidines: Novel CRF-1 receptor antagonists

Organic Chemistry / Depression / Kinetics / Pharmacokinetics / Pharmaceutical Chemistry / In Vitro / Humans / Animals / Drug Design / Solubility / In Vivo / Rats / Rat / Ether / Molecular Conformation / Bioorganic and medicinal Chemistry / Affinity / Structure activity Relationship / Chemical Synthesis / Molecular Structure / In Vitro / Humans / Animals / Drug Design / Solubility / In Vivo / Rats / Rat / Ether / Molecular Conformation / Bioorganic and medicinal Chemistry / Affinity / Structure activity Relationship / Chemical Synthesis / Molecular Structure

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Phosphonic pseudopeptides as human neutrophil elastase inhibitors—a combinatorial approach

Organic Chemistry / Cystic Fibrosis / Rheumatoid Arthritis / Single molecule / Humans / Trypsin / Serine Proteases / Second Order / Gingiva / Bioorganic and medicinal Chemistry / Cell Proliferation / Biological activity / Human Fibroblasts / Serine Protease / Cell Survival / Tumor Growth / Molecular Structure / Chymotrypsin / Trypsin / Serine Proteases / Second Order / Gingiva / Bioorganic and medicinal Chemistry / Cell Proliferation / Biological activity / Human Fibroblasts / Serine Protease / Cell Survival / Tumor Growth / Molecular Structure / Chymotrypsin

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Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 α-amino acid by a α-hydroxy acid

Organic Chemistry / Apoptosis / Humans / Mice / Animals / D-Aspartic Acid / Amino Acids / Spectrum / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Cysteine Proteinase Inhibitors / D-Aspartic Acid / Amino Acids / Spectrum / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Cysteine Proteinase Inhibitors

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Antiprotozoal activities of symmetrical bishydroxamic acids

Organic Chemistry / Animals / Iron / Plasmodium falciparum / Bioorganic and medicinal Chemistry / Structure activity Relationship / Hydroxamic Acids / Structure activity Relationship / Hydroxamic Acids

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