Bioorganic and medicinal Chemistry

1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

Organic Chemistry / Mice / Animals / Voltage-Gated Potassium Channels / Seizures / Bioorganic and medicinal Chemistry / Imidazoles / Bioorganic and medicinal Chemistry / Imidazoles

Diaryl piperidines as CB1 receptor antagonists

Organic Chemistry / Obesity / Diet / Mice / Animals / Eating / Food intake / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / CB 1 receptor / Piperidines / Eating / Food intake / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / CB 1 receptor / Piperidines

Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Humans / Kinase inhibitor / Hydrogen Bond / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Alkynes / Molecular Structure / Receptor Tyrosine Kinase / Hydrogen Bond / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Alkynes / Molecular Structure / Receptor Tyrosine Kinase

RGD Mimetics containing a central hydantoin scaffold: αVβ3 vs αIIbβ3 selectivity requirements

Organic Chemistry / Fibrinogen / Humans / Peptides / Bioorganic and medicinal Chemistry / Imidazoles / Protein Binding / Molecular Structure / Imidazoles / Protein Binding / Molecular Structure

Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

Organic Chemistry / Humans / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Vascular Endothelial Growth Factor

3D-QSAR design of novel antiepileptic sulfamides

Organic Chemistry / Epilepsy / Mice / Female / Animals / Male / Drug Design / Quantitative Structure Activity Relationship / Three Dimensional / Bioorganic and medicinal Chemistry / Structure activity Relationship / Ligands / Molecular Structure / Male / Drug Design / Quantitative Structure Activity Relationship / Three Dimensional / Bioorganic and medicinal Chemistry / Structure activity Relationship / Ligands / Molecular Structure

Tetrahydro-4-quinolinamines identified as novel P2Y1 receptor antagonists

Organic Chemistry / Humans / Platelet aggregation / High throughput screening / Thrombosis / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure

Tetrahydro-4-Quinolinamines Identified as Novel P2Y1 Receptor Antagonists

Organic Chemistry / Humans / Platelet aggregation / High throughput screening / Thrombosis / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure

Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs

Organic Chemistry / Fungi / Molecular modeling / Bacteria / Antifungal Activity / Structure Elucidation / Anti-Bacterial Agents / Antifungal Agents / Microbial Sensitivity Tests / Bioorganic and medicinal Chemistry / Thiazoles / Structure activity Relationship / Structure Elucidation / Anti-Bacterial Agents / Antifungal Agents / Microbial Sensitivity Tests / Bioorganic and medicinal Chemistry / Thiazoles / Structure activity Relationship

Diaryl piperidines as CB1 receptor antagonists

Organic Chemistry / Obesity / Diet / Mice / Animals / Eating / Food intake / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / CB 1 receptor / Piperidines / Eating / Food intake / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / CB 1 receptor / Piperidines

Benzylidene ketal derivatives as M2 muscarinic receptor antagonists

Organic Chemistry / Bioorganic and medicinal Chemistry / Muscarinic Receptor

Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification

Organic Chemistry / Humans / Animals / Drug Design / Acetylcholine / Microdialysis / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Area Under Curve / Benzamides / Microdialysis / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Area Under Curve / Benzamides

Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist

Organic Chemistry / Asthma / Mice / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Piperidines / Airway Inflammation / Structure activity Relationship / Piperidines / Airway Inflammation

Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines

Organic Chemistry / Drug development / Cell line / Tuberculosis / Humans / Mycobacterium tuberculosis / Developing Country / Infectious Disease / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry / Mycobacterium tuberculosis / Developing Country / Infectious Disease / Trypanosoma Cruzi / Cytotoxic Activity / Bioorganic and medicinal Chemistry

New vasorelaxant indole alkaloids, villocarines A–D from Uncaria villosa

Organic Chemistry / Calcium / Pharmacognosy / Magnetic Resonance Spectroscopy / Structural Analysis / In Vitro / Endothelial Cells / Nitric oxide / Animals / Calcium channels / Potassium / Isolation / Rats / Endothelial cell / Rat / Voltage-Gated Potassium Channels / Molecular Conformation / Bioorganic and medicinal Chemistry / Biological activity / Uncaria / Aorta / Indole Alkaloids / Plant Leaves / In Vitro / Endothelial Cells / Nitric oxide / Animals / Calcium channels / Potassium / Isolation / Rats / Endothelial cell / Rat / Voltage-Gated Potassium Channels / Molecular Conformation / Bioorganic and medicinal Chemistry / Biological activity / Uncaria / Aorta / Indole Alkaloids / Plant Leaves

Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure–activity study

Organic Chemistry / Biofilms / Discriminant Analysis / Escherichia coli / Quantitative Structure Activity Relationship / Anti-Bacterial Agents / Bioorganic and medicinal Chemistry / Anti-Bacterial Agents / Bioorganic and medicinal Chemistry

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