Bioorganic and medicinal Chemistry

Identification of 2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-pyrazol-1-yl]-N-propionylbenzenesulfonamide sodium as a potential COX-2 inhibitor for oral and parenteral administration

Organic Chemistry / Enzyme Inhibitors / Prodrugs / Humans / Animals / Male / Solubility / Rats / Edema / Fever / Foot / Wistar Rats / Carrageenan / Water soluble polymers / Bioorganic and medicinal Chemistry / Structure activity Relationship / Hyperalgesia / Endotoxins / Molecular Structure / Male / Solubility / Rats / Edema / Fever / Foot / Wistar Rats / Carrageenan / Water soluble polymers / Bioorganic and medicinal Chemistry / Structure activity Relationship / Hyperalgesia / Endotoxins / Molecular Structure

8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno-[1,2-e]pyrazines: highly potent in vivo AMPA antagonists

Organic Chemistry / Mice / Animals / Xenopus laevis / Water soluble polymers / Seizures / Acetic Acid / Bioorganic and medicinal Chemistry / Oocytes / Seizures / Acetic Acid / Bioorganic and medicinal Chemistry / Oocytes

Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase

Organic Chemistry / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / Humans / Zinc / Enzyme / Bioorganic and medicinal Chemistry / Chelating Agents / Hydroxamic Acids / Enzyme / Bioorganic and medicinal Chemistry / Chelating Agents / Hydroxamic Acids

Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs

Organic Chemistry / Medical Microbiology / Bioorganic and medicinal Chemistry / Antiviral / Hepatitis B virus / Antiviral Activity / Transgenic Mouse Technology / Antiviral Activity / Transgenic Mouse Technology

Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs

Organic Chemistry / Medical Microbiology / Cell line / Hepatitis B / Prodrugs / Humans / Mutation / Mice / Female / Animals / Male / Rats / Bioorganic and medicinal Chemistry / Antiviral / Hepatitis B virus / Antiviral Activity / Transgenic Mouse Technology / Nucleotides / Antiviral Agents / Humans / Mutation / Mice / Female / Animals / Male / Rats / Bioorganic and medicinal Chemistry / Antiviral / Hepatitis B virus / Antiviral Activity / Transgenic Mouse Technology / Nucleotides / Antiviral Agents

Fatty acid amide hydrolase substrate specificity

Organic Chemistry / Animals / Rats / Substrate Specificity / Fatty Acid / Bioorganic and medicinal Chemistry / Recombinant Proteins / Hydrolysis / Bioorganic and medicinal Chemistry / Recombinant Proteins / Hydrolysis

3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3

Organic Chemistry / Apoptosis / Cell line / Stroke / Escherichia coli / Signal Transduction Pathway Models / Caspase / Protease Inhibitors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Signal Transduction Pathway Models / Caspase / Protease Inhibitors / Bioorganic and medicinal Chemistry / Structure activity Relationship

3-(5-Alkylamino-4-isoxazolyl)-1,2,5,6-tetrahydropyridines: a novel class of central nicotinic receptor ligands

Organic Chemistry / Mass Spectrometry / Magnetic Resonance Spectroscopy / Cerebral Cortex / Animals / Male / Nicotinic Acetylcholine Receptors / Rats / Pyridines / Wistar Rats / Bioorganic and medicinal Chemistry / Muscarinic Receptor / Ligands / Male / Nicotinic Acetylcholine Receptors / Rats / Pyridines / Wistar Rats / Bioorganic and medicinal Chemistry / Muscarinic Receptor / Ligands

3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents

Organic Chemistry / Phase I clinical trial design / Glaucoma / Animals / Intraocular Pressure / Topical Drug Administration / Bioorganic and medicinal Chemistry / Rabbits / Hydrogen Atom / Structure activity Relationship / Protein Binding / Prostaglandin E2 / Molecular Structure / Topical Drug Administration / Bioorganic and medicinal Chemistry / Rabbits / Hydrogen Atom / Structure activity Relationship / Protein Binding / Prostaglandin E2 / Molecular Structure

In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity

Organic Chemistry / Medicinal Chemistry / Obesity / Pharmaceutical Chemistry / Dogs / Humans / Animals / Drug Design / Enzyme / Food intake / Rats / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Carbamates / Humans / Animals / Drug Design / Enzyme / Food intake / Rats / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Carbamates

Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

Organic Chemistry / Humans / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Vascular Endothelial Growth Factor

New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / DBA / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing

3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3

Organic Chemistry / Apoptosis / Cell line / Stroke / Escherichia coli / Signal Transduction Pathway Models / Caspase / Protease Inhibitors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Signal Transduction Pathway Models / Caspase / Protease Inhibitors / Bioorganic and medicinal Chemistry / Structure activity Relationship

Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists

Organic Chemistry / Animals / Enzyme / Rats / Oximes / Substrate Specificity / Pyridines / Bioorganic and medicinal Chemistry / Carbamates / Substrate Specificity / Pyridines / Bioorganic and medicinal Chemistry / Carbamates

Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists

Organic Chemistry / Calcium / Animals / Rats / Bioorganic and medicinal Chemistry / Benzimidazoles / Cell Survival / Glutamic Acid / Benzimidazoles / Cell Survival / Glutamic Acid

Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): A novel class of antimicrobial compounds

Organic Chemistry / Kinetics / Enzyme Inhibitors / Escherichia coli / Anti-Bacterial Agents / Substrate Specificity / Bioorganic and medicinal Chemistry / Structure activity Relationship / Glutamate Dehydrogenase / Molecular Structure / Transaminases / Substrate Specificity / Bioorganic and medicinal Chemistry / Structure activity Relationship / Glutamate Dehydrogenase / Molecular Structure / Transaminases

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