Bioorganic and medicinal Chemistry

Cubyl amides: Novel P2X7 receptor antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / Animals / Spinal Cord / Microglia / Drug Design / High Pressure Liquid Chromatography / Rational drug design / Amides / Rats / Molecular Conformation / Bioorganic and medicinal Chemistry / Benzamides / Spinal Cord / Microglia / Drug Design / High Pressure Liquid Chromatography / Rational drug design / Amides / Rats / Molecular Conformation / Bioorganic and medicinal Chemistry / Benzamides

5-aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists

Organic Chemistry / Mice / Animals / Water soluble polymers / Seizures / Bioorganic and medicinal Chemistry / Binding Site / Bioorganic and medicinal Chemistry / Binding Site

5-aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists

Organic Chemistry / Glycine / Bioorganic and medicinal Chemistry / Structure activity Relationship / Binding Site

Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 α-amino acid by a α-hydroxy acid

Organic Chemistry / Apoptosis / Humans / Mice / Animals / D-Aspartic Acid / Amino Acids / Spectrum / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Cysteine Proteinase Inhibitors / D-Aspartic Acid / Amino Acids / Spectrum / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Cysteine Proteinase Inhibitors

Cubyl amides: Novel P2X7 receptor antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / Animals / Spinal Cord / Microglia / Drug Design / High Pressure Liquid Chromatography / Rational drug design / Amides / Rats / Molecular Conformation / Bioorganic and medicinal Chemistry / Benzamides / Spinal Cord / Microglia / Drug Design / High Pressure Liquid Chromatography / Rational drug design / Amides / Rats / Molecular Conformation / Bioorganic and medicinal Chemistry / Benzamides

Proxyl nitroxide of lithocholic acid: A potential spin probe for model membranes

Organic Chemistry / Magnetic Resonance Spectroscopy / Permeability / Lidocaine / Bioorganic and medicinal Chemistry / Lipid bilayers / Membrane Fluidity / Molecular Structure / Lipid bilayers / Membrane Fluidity / Molecular Structure

Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

Organic Chemistry / Cell line / Humans / Mice / Animals / Anti-inflammatory agents / Lipopolysaccharides / Rats / Tumor necrosis factor-alpha / Bioorganic and medicinal Chemistry / Heterocyclic compounds / Glucocorticoids / Anti-inflammatory agents / Lipopolysaccharides / Rats / Tumor necrosis factor-alpha / Bioorganic and medicinal Chemistry / Heterocyclic compounds / Glucocorticoids

Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

Organic Chemistry / Cell line / Humans / Mice / Animals / Anti-inflammatory agents / Lipopolysaccharides / Rats / Tumor necrosis factor-alpha / Bioorganic and medicinal Chemistry / Heterocyclic compounds / Glucocorticoids / Anti-inflammatory agents / Lipopolysaccharides / Rats / Tumor necrosis factor-alpha / Bioorganic and medicinal Chemistry / Heterocyclic compounds / Glucocorticoids

New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / DBA / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing

8-amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists

Organic Chemistry / Bioorganic and medicinal Chemistry / Binding affinity

Azabicyclic indole esters as potent 5-HT4 receptor antagonists

Organic Chemistry / Animals / Serotonin Receptors / Bioorganic and medicinal Chemistry / Colon / Structure activity Relationship / Serotonin antagonists / Structure activity Relationship / Serotonin antagonists

2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists

Organic Chemistry / Physical Chemistry / Humans / Drug Design / Bioorganic and medicinal Chemistry / Structure activity Relationship

New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / DBA / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing

Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents

Organic Chemistry / Bioorganic and medicinal Chemistry

Oxazolidinones as novel human CCR8 antagonists

Organic Chemistry / Chemokines and chemokine receptors / Humans / Computer Simulation / High throughput screening / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Oxazolidinones / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Oxazolidinones

2-Aminomethyl piperidines as novel urotensin-II receptor antagonists

Organic Chemistry / Humans / G protein-coupled receptors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Piperidines

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