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Bioorganic and medicinal Chemistry
Bioorganic and medicinal Chemistry
N-(Sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines: potent antagonists of human neuropeptide Y Y5 receptor
Organic Chemistry / Macromolecular X-Ray Crystallography / Humans / Neuropeptide Y / Bioorganic and medicinal Chemistry / Molecular Structure
Novel non-peptidic neuropeptide Y Y2 receptor antagonists
Organic Chemistry / Humans / Neuropeptide Y / Bioorganic and medicinal Chemistry / Protein Binding / Low molecular weight / Piperidines / Low molecular weight / Piperidines
Novel coumarin derivatives as potential antidyslipidemic agents
Organic Chemistry / Humans / Antioxidant Activity / Coumarins / Bioorganic and medicinal Chemistry
Novel non-peptidic neuropeptide Y Y2 receptor antagonists
Organic Chemistry / Humans / Neuropeptide Y / Bioorganic and medicinal Chemistry / Protein Binding / Low molecular weight / Piperidines / Low molecular weight / Piperidines
8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno-[1,2-e]pyrazines: highly potent in vivo AMPA antagonists
Organic Chemistry / Mice / Animals / Xenopus laevis / Water soluble polymers / Seizures / Acetic Acid / Bioorganic and medicinal Chemistry / Oocytes / Tetrazoles / Seizures / Acetic Acid / Bioorganic and medicinal Chemistry / Oocytes / Tetrazoles
A novel sesquiterpene lactone from Centaurea pullata: Structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties
Organic Chemistry / Prediction / Pharmacokinetics / Pharmacognosy / Magnetic Resonance Spectroscopy / Structural Analysis / Cell line / In Vitro / Antimicrobial activity / Antifungal Activity / Sesquiterpenes / Antibacterial activity / Isolation / Structure Elucidation / Anti-Bacterial Agents / Water Solubility / ADME / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Microbial Viability / Centaurea / Lactones / Computational Method / Molecular Structure / Terpenoid / Structural Analysis / Cell line / In Vitro / Antimicrobial activity / Antifungal Activity / Sesquiterpenes / Antibacterial activity / Isolation / Structure Elucidation / Anti-Bacterial Agents / Water Solubility / ADME / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Microbial Viability / Centaurea / Lactones / Computational Method / Molecular Structure / Terpenoid
A novel sesquiterpene lactone from Centaurea pullata : Structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties
Organic Chemistry / Prediction / Pharmacokinetics / Pharmacognosy / Magnetic Resonance Spectroscopy / Structural Analysis / Cell line / In Vitro / Antimicrobial activity / Antifungal Activity / Sesquiterpenes / Antibacterial activity / Isolation / Structure Elucidation / Anti-Bacterial Agents / Water Solubility / ADME / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Microbial Viability / Centaurea / Lactones / Computational Method / Molecular Structure / Terpenoid / Structural Analysis / Cell line / In Vitro / Antimicrobial activity / Antifungal Activity / Sesquiterpenes / Antibacterial activity / Isolation / Structure Elucidation / Anti-Bacterial Agents / Water Solubility / ADME / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Microbial Viability / Centaurea / Lactones / Computational Method / Molecular Structure / Terpenoid
New imidazolidinedione derivatives as antimalarial agents
Organic Chemistry / Treatment / Prevention / In Vitro / Humans / Mice / Animals / Rhesus Monkey / Plasmodium falciparum / Antimalarials / Macaca Mulatta / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Mono / Plasmodium berghei / Molecular Structure / Mice / Animals / Rhesus Monkey / Plasmodium falciparum / Antimalarials / Macaca Mulatta / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Mono / Plasmodium berghei / Molecular Structure
New imidazolidinedione derivatives as antimalarial agents
Organic Chemistry / Treatment / Prevention / In Vitro / Humans / Mice / Animals / Rhesus Monkey / Plasmodium falciparum / Antimalarials / Macaca Mulatta / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Mono / Plasmodium berghei / Molecular Structure / Mice / Animals / Rhesus Monkey / Plasmodium falciparum / Antimalarials / Macaca Mulatta / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Mono / Plasmodium berghei / Molecular Structure
Novel antibacterial azetidine lincosamides
Organic Chemistry / Protein synthesis / Anti-Bacterial Agents / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Microbial Viability / Protein Biosynthesis / Molecular Structure / Macrolides / Lincosamides / Structure activity Relationship / Microbial Viability / Protein Biosynthesis / Molecular Structure / Macrolides / Lincosamides
1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists
Organic Chemistry / Mice / Animals / Voltage-Gated Potassium Channels / Seizures / Bioorganic and medicinal Chemistry / Imidazoles / Bioorganic and medicinal Chemistry / Imidazoles
Peptide chemical ligation inside living cells: in vivo generation of a circular protein domain
Organic Chemistry / Mass Spectrometry / Biology / Medicine / Protein Engineering / HPLC / Escherichia coli / Mice / Animals / Bacteria / Nmr / Magnetic Resonance / Cyclic peptides / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Map / High Pressure Liquid Chromatography / In Vivo / Protein Domains / Liquid Chromatography / Quantum correlations / Cyclization / Amino Acid Profile / HSQC / Bioorganic and medicinal Chemistry / Biological activity / Protein Binding / SH / HPLC / Escherichia coli / Mice / Animals / Bacteria / Nmr / Magnetic Resonance / Cyclic peptides / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Map / High Pressure Liquid Chromatography / In Vivo / Protein Domains / Liquid Chromatography / Quantum correlations / Cyclization / Amino Acid Profile / HSQC / Bioorganic and medicinal Chemistry / Biological activity / Protein Binding / SH
Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents
Organic Chemistry / Prevention / Cell line / In Vitro / Humans / Endothelial Cells / Drug Design / Endothelial cell / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Endothelial Cells / Drug Design / Endothelial cell / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis
Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): A novel class of antimicrobial compounds
Organic Chemistry / Kinetics / Enzyme Inhibitors / Escherichia coli / Anti-Bacterial Agents / Substrate Specificity / Bioorganic and medicinal Chemistry / Structure activity Relationship / Glutamate Dehydrogenase / Molecular Structure / Transaminases / Substrate Specificity / Bioorganic and medicinal Chemistry / Structure activity Relationship / Glutamate Dehydrogenase / Molecular Structure / Transaminases
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity
Organic Chemistry / Cancer / Mice / Animals / Drug Design / Kinase inhibitor / Bioorganic and medicinal Chemistry / Biological activity / Aurora kinases / Structure activity Relationship / Molecular Structure / Vascular endothelial growth factor receptor / Aurora B / Kinase inhibitor / Bioorganic and medicinal Chemistry / Biological activity / Aurora kinases / Structure activity Relationship / Molecular Structure / Vascular endothelial growth factor receptor / Aurora B
4-(2-Pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists
Organic Chemistry / Cell line / Humans / Animals / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bioorganic and medicinal Chemistry / Structure activity Relationship
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