Bioorganic and medicinal Chemistry

Non-Peptide αvβ3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-Amino acids as aspartic acid replacements

Organic Chemistry / Dogs / Osteoporosis / Humans / Animals / D-Aspartic Acid / Amino Acids / Molecular Mimicry / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Physicochemical Properties / D-Aspartic Acid / Amino Acids / Molecular Mimicry / Amino Acid Profile / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Physicochemical Properties

Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

Organic Chemistry / Humans / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Vascular Endothelial Growth Factor

Anti-tumor agents 255: Novel glycyrrhetinic acid–dehydrozingerone conjugates as cytotoxic agents

Organic Chemistry / Drug Discovery / Humans / Ursolic Acid / Cytotoxic Activity / Neoplasms / Bioorganic and medicinal Chemistry / Structure activity Relationship / Antineoplastic Agents / Cytotoxins / Molecular Structure / Neoplasms / Bioorganic and medicinal Chemistry / Structure activity Relationship / Antineoplastic Agents / Cytotoxins / Molecular Structure

1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

Organic Chemistry / Mice / Animals / Voltage-Gated Potassium Channels / Seizures / Bioorganic and medicinal Chemistry / Imidazoles / Bioorganic and medicinal Chemistry / Imidazoles

Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists

Organic Chemistry / In Vitro / Animals / Metabotropic Glutamate Receptors / Enzyme / Rats / Oximes / Substrate Specificity / Pyridines / Bioorganic and medicinal Chemistry / Affinity / Chemical Synthesis / Carbamates / Rats / Oximes / Substrate Specificity / Pyridines / Bioorganic and medicinal Chemistry / Affinity / Chemical Synthesis / Carbamates

Oxazolidinones as novel human CCR8 antagonists

Organic Chemistry / Chemokines and chemokine receptors / Humans / Computer Simulation / High throughput screening / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Oxazolidinones / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Oxazolidinones

Antimalarial benzo[c]phenanthridines

Organic Chemistry / Humans / Animals / Plasmodium falciparum / Antimalarials / Microbial Sensitivity Tests / Bioorganic and medicinal Chemistry / Netropsin / Microbial Sensitivity Tests / Bioorganic and medicinal Chemistry / Netropsin

Synthetic peptides derived from the sequence of a lasso peptide microcin J25 show antibacterial activity

Organic Chemistry / Protein Folding / Humans / Bacteriocins / Peptides / Anti-Bacterial Agents / Protein Conformation / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Anti-Bacterial Agents / Protein Conformation / Bioorganic and medicinal Chemistry / Amino Acid Sequence

Keto C-glycosides. a new class of antitumor compounds

Organic Chemistry / Bioorganic and medicinal Chemistry

Phosphonic pseudopeptides as human neutrophil elastase inhibitors—a combinatorial approach

Organic Chemistry / Cystic Fibrosis / Rheumatoid Arthritis / Single molecule / Humans / Trypsin / Serine Proteases / Second Order / Gingiva / Bioorganic and medicinal Chemistry / Cell Proliferation / Biological activity / Human Fibroblasts / Serine Protease / Cell Survival / Tumor Growth / Molecular Structure / Chymotrypsin / Trypsin / Serine Proteases / Second Order / Gingiva / Bioorganic and medicinal Chemistry / Cell Proliferation / Biological activity / Human Fibroblasts / Serine Protease / Cell Survival / Tumor Growth / Molecular Structure / Chymotrypsin

4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists

Organic Chemistry / Bioorganic and medicinal Chemistry

Aza-bicyclic amino acid carboxamides as α4β1/α4β7 integrin receptor antagonists

Organic Chemistry / Multiple sclerosis / Rheumatoid Arthritis / Inflammatory Bowel Disease / Amino Acid Profile / Bioorganic and medicinal Chemistry

RGD Mimetics containing a central hydantoin scaffold: αVβ3 vs αIIbβ3 selectivity requirements

Organic Chemistry / Fibrinogen / Humans / Peptides / Bioorganic and medicinal Chemistry / Imidazoles / Protein Binding / Molecular Structure / Imidazoles / Protein Binding / Molecular Structure

Polyamide Amino Acids trimers as TAR RNA ligands and anti-HIV agents

Organic Chemistry / Fluorescence Resonance Energy Transfer / Cell Culture / Amino Acids / Amino Acid Profile / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Antiviral Activity / Ligands / Bioorganic and medicinal Chemistry / Amino Acid Sequence / Antiviral Activity / Ligands

(Z,E)-α-Farnesene—An electroantennogram-active component of Maladera matrida volatiles

Organic Chemistry / Gas Chromatography / Bioorganic and medicinal Chemistry / Plant Volatiles

Application of the Suzuki–Miyaura cross-coupling to increase antimicrobial potency generates promising novel antibacterials

Organic Chemistry / Clinical Trial / Pharmacokinetics / Patch-clamp and imaging techniques / Humans / Mice / Animals / Calcium Signaling / Antimicrobial Peptide / Gram Positive Bacteria / Anti-Bacterial Agents / Bioorganic and medicinal Chemistry / Protein Binding / DNA binding proteins / Mice / Animals / Calcium Signaling / Antimicrobial Peptide / Gram Positive Bacteria / Anti-Bacterial Agents / Bioorganic and medicinal Chemistry / Protein Binding / DNA binding proteins

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