Medicinal Chemistry

N -Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds

Pharmacology / Chemistry / Organic Chemistry / Pharmacy / Medicinal Chemistry / Malaria / Humans / Animals / Rats / Hepatocytes / Plasmodium falciparum / Antimalarials / Benzimidazoles / Structure activity Relationship / Plasmodium berghei / Malaria / Humans / Animals / Rats / Hepatocytes / Plasmodium falciparum / Antimalarials / Benzimidazoles / Structure activity Relationship / Plasmodium berghei

Bioactive Fungal Endoperoxides

Organic Chemistry / Medicinal Chemistry / Fungi

New transient receptor potential TRPV1, TRPM8 and TRPA1 channel antagonists from a single linear b,g-diamino ester scaffold

Chemistry / Medicinal Chemistry / Drug Discovery / Ion Channels / TRP Channels

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Microbiology / Medicinal Chemistry / Molecular Biology / Biology / Malaria / Enzyme Inhibitors / Public Health / Biological Sciences / Humans / Protease / Endoplasmic Reticulum / Host Parasite Interaction / Protozoan Proteins / Erythrocytes / Protein Transport / Enzyme Inhibitors / Public Health / Biological Sciences / Humans / Protease / Endoplasmic Reticulum / Host Parasite Interaction / Protozoan Proteins / Erythrocytes / Protein Transport

Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogs)

Organic Chemistry / Medicinal Chemistry / Pancreas / Animals / Male / Acetylcholine / Rats / Medicinal / Muscle contraction / Transfection / Muscarinic Receptor / Molecular Structure / Ileum / Acetylcholine / Rats / Medicinal / Muscle contraction / Transfection / Muscarinic Receptor / Molecular Structure / Ileum

Antiprotozoal quinones. IV. 2-Amino-1,4-naphthoquinone imines as potential antimalarials

Organic Chemistry / Medicinal Chemistry / Malaria / Mice / Animals / Antimalarials

Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Humans / Kinase inhibitor / Hydrogen Bond / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Alkynes / Molecular Structure / Receptor Tyrosine Kinase / Hydrogen Bond / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Alkynes / Molecular Structure / Receptor Tyrosine Kinase

Design and Synthesis of N 1 ,N 5 -bis[4-(5-Alkyl-1,2,4-oxadiazol-3- yl)phenyl]glutaramides as Potential Antifungal Prodrugs

Organic Chemistry / Medicinal Chemistry

Discovery of 5-[[4-[(2,3-Dimethyl-2 H -indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor †

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Humans / Cancer Therapy / Mice / Animals / Isoenzymes / Medicinal / Neoplasms / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Vascular endothelial growth factor receptor / Mice / Animals / Isoenzymes / Medicinal / Neoplasms / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Vascular endothelial growth factor receptor

Novel tetracyclic spiropiperidines. 1. 3-Aryl-1,3-dihydrospiro[benzo[c]thiophene-1,4\'-piperidines] as potential antidepressants

Chemistry / Organic Chemistry / Medicinal Chemistry / Mice / Animals / Male / Medicinal / Piperidines / Tetrabenazine / Male / Medicinal / Piperidines / Tetrabenazine

Novel tetracyclic spiropiperidines. 3. 1-Arylspiro[indoline-3,4\'-piperidine]s as potential antidepressants

Organic Chemistry / Medicinal Chemistry / Humans / Animals / Medicinal / Structure activity Relationship / Biological Assay / Piperidines / Tetrabenazine / Structure activity Relationship / Biological Assay / Piperidines / Tetrabenazine

4- N -, 4- S -, and 4- O -Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen p K a on Activity vs Chloroquine Resistant Malaria

Organic Chemistry / Medicinal Chemistry / Fluorescent Dyes and Reagents / Animals / Drug Resistance / Nitrogen / Medicinal / Plasmodium falciparum / Antimalarials / Chloroquine / Structure activity Relationship / Organic Chemicals / "Intercalating Agents" / Nitrogen / Medicinal / Plasmodium falciparum / Antimalarials / Chloroquine / Structure activity Relationship / Organic Chemicals / "Intercalating Agents"

A Novel Cell-Penetrating Peptide Sequence Derived by Structural Minimization of a Snake Toxin Exhibits Preferential Nucleolar Localization

Organic Chemistry / Medicinal Chemistry / Snake venoms / Humans / Animals / HeLa cells / Medicinal / Amino Acid Sequence / Protein Transport / HeLa cells / Medicinal / Amino Acid Sequence / Protein Transport

Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model

Organic Chemistry / Medicinal Chemistry / Animals / Structural equation models / Male / dopamine receptor D4 / Dopamine Receptors / Rats / Medicinal / Molecular Conformation / Structure activity Relationship / Piperidines / Motor activity / dopamine receptor D4 / Dopamine Receptors / Rats / Medicinal / Molecular Conformation / Structure activity Relationship / Piperidines / Motor activity

Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model

Organic Chemistry / Medicinal Chemistry / Animals / Structural equation models / Male / dopamine receptor D4 / Dopamine Receptors / Rats / Molecular Conformation / Structure activity Relationship / Piperidines / Motor activity / dopamine receptor D4 / Dopamine Receptors / Rats / Molecular Conformation / Structure activity Relationship / Piperidines / Motor activity

Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?

Medicinal Chemistry / Medicinal chemistry and pharmaceutical chemistry / Hippocampus / Humans / Animals / Temporal Lobe Epilepsy / Pharmacogenomics Antiepileptic drugs / Mesial Temporal Sclerosis / Antiepileptic drugs / Antiepileptic Drug / Temporal Lobe Epilepsy / Pharmacogenomics Antiepileptic drugs / Mesial Temporal Sclerosis / Antiepileptic drugs / Antiepileptic Drug

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