Medicinal Chemistry - Page 5

Cyclic α-Amino Acids via Enantioselective Metal-Catalyzed Cascade Reactions of Dienamides in Supercritical Carbon Dioxide

Analytical Chemistry / Computational Chemistry / Quantum Chemistry / Inorganic Chemistry / Organic Chemistry / Physical Chemistry / Crystallography / Medicinal Chemistry / Polymer Chemistry / Reaction Mechanisms / Green Chemistry / Structure / Biosensors / Supramolecular Chemistry / Electrochemistry / Catalysis / Kinetics / Photochemistry / Spectroscopy / Mass Spectrometry / Self Assembly / Nanotechnology / Biological Chemistry / Pharmaceutical Chemistry / Surface Chemistry / Ionic Liquids / Biocatalysis / Ab initio calculations / Sensors / Scientific / Educational / Density Functional Theory / Combinatorial Chemistry / Colloids / Macromolecules / Interfaces / Proteins / CHEMICAL SCIENCES / Supercritical carbon dioxide / Crystal Structures / BioSensors / Combinatorial / Physical Chemistry / Crystallography / Medicinal Chemistry / Polymer Chemistry / Reaction Mechanisms / Green Chemistry / Structure / Biosensors / Supramolecular Chemistry / Electrochemistry / Catalysis / Kinetics / Photochemistry / Spectroscopy / Mass Spectrometry / Self Assembly / Nanotechnology / Biological Chemistry / Pharmaceutical Chemistry / Surface Chemistry / Ionic Liquids / Biocatalysis / Ab initio calculations / Sensors / Scientific / Educational / Density Functional Theory / Combinatorial Chemistry / Colloids / Macromolecules / Interfaces / Proteins / CHEMICAL SCIENCES / Supercritical carbon dioxide / Crystal Structures / BioSensors / Combinatorial

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Discovery and Preclinical Pharmacology of a Novel, Potent, Nonsteroidal Estrogen Receptor Agonist/Antagonist, CP-336156, a Diaryltetrahydronaphthalene

Organic Chemistry / Medicinal Chemistry / Cell Division / Estrogen Receptor / Humans / Cholesterol / Female / Animals / Bone Density / Rats / Medicinal / Uterus / Biological Availability / #Hypolipidemic Agents / Ovariectomy / Cholesterol / Female / Animals / Bone Density / Rats / Medicinal / Uterus / Biological Availability / #Hypolipidemic Agents / Ovariectomy

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1-Aryl-3,5-dihydro-4 H -2,3-benzodiazepin-4-ones: Novel AMPA Receptor Antagonists

Organic Chemistry / Medicinal Chemistry / Mice / Animals / Medicinal / Seizures / Pentylenetetrazole / Seizures / Pentylenetetrazole

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Acacia catechu hard wood: potential anti-diabetic cum anti-dyslipidemic

Biochemistry / Medicinal Chemistry / Low Dose / Streptozotocin / Active Ingredient / Diabetic Rat / Aqueous Extract / Total Cholesterol / High fat diet / Diabetic Rat / Aqueous Extract / Total Cholesterol / High fat diet

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Conformationally Constrained [ p -(ω-Aminoalkyl)phenacetyl]- l -seryl- l -lysyl Dipeptide Amides as Potent Peptidomimetic Inhibitors of Candida albicans and Human Myristoyl-CoA:Protein N -Myristoyl Transferase

Organic Chemistry / Medicinal Chemistry / In Vitro / Candida albicans / Medicinal / Chemical Synthesis / Thallophyta / Chemical Synthesis / Thallophyta

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Conformationally Constrained [ p -(ω-Aminoalkyl)phenacetyl]- l -seryl- l -lysyl Dipeptide Amides as Potent Peptidomimetic Inhibitors of Candida albicans and Human Myristoyl-CoA:Protein N -Myristoyl Transferase

Organic Chemistry / Medicinal Chemistry / In Vitro / Candida albicans / Medicinal / Chemical Synthesis / Thallophyta / Chemical Synthesis / Thallophyta

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5,6-Diphenylpyridazine Derivatives as Acyl-CoA:Cholesterol Acyltransferase Inhibitors

Organic Chemistry / Medicinal Chemistry / Enzyme Inhibitors / Macrophages / Mice / Animals / Rats / Medicinal / Cell free System / Structure activity Relationship / Animals / Rats / Medicinal / Cell free System / Structure activity Relationship

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Discovery of 5-[[4-[(2,3-Dimethyl-2 H -indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor †

Organic Chemistry / Medicinal Chemistry / Pharmacokinetics / Macromolecular X-Ray Crystallography / Cell line / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor

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A comparison of mutagenic and carcinogenic activities of aniline mustards

Organic Chemistry / Medicinal Chemistry / Mice / Animals / Carcinogens / Medicinal / Adenoma / Mutagens / Medicinal / Adenoma / Mutagens

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Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes

Algorithms / Organic Chemistry / Water / Medicinal Chemistry / Entropy / Quantitative Structure Activity Relationship / Proteins / Metals / Hydrogen Bonding / Medicinal / Ligands / Quantitative Structure Activity Relationship / Proteins / Metals / Hydrogen Bonding / Medicinal / Ligands

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Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context

Biochemistry / Medicinal Chemistry / Toxicology / Bioinorganic Chemistry / Organic Synthesis / Humans / Mice / Animals / Rats / Species Specificity / Humans / Mice / Animals / Rats / Species Specificity

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Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?

Medicinal Chemistry / Medicinal chemistry and pharmaceutical chemistry / Hippocampus / Humans / Animals / Temporal Lobe Epilepsy / Pharmacogenomics Antiepileptic drugs / Mesial Temporal Sclerosis / Antiepileptic drugs / Antiepileptic Drug / Brain injuries / Temporal Lobe Epilepsy / Pharmacogenomics Antiepileptic drugs / Mesial Temporal Sclerosis / Antiepileptic drugs / Antiepileptic Drug / Brain injuries

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Helical Antimicrobial Sulfono-γ-AApeptides

Organic Chemistry / Medicinal Chemistry / Small angle X-ray and neutron scattering / Fluorescence Microscopy / Humans / Peptidomimetics / Gram-negative bacteria / Anti-Bacterial Agents / Antimicrobial Cationic Peptides / Microbial Sensitivity Tests / Cell Proliferation / Structure activity Relationship / Erythrocytes / Molecular Structure / Hemolysis / Peptidomimetics / Gram-negative bacteria / Anti-Bacterial Agents / Antimicrobial Cationic Peptides / Microbial Sensitivity Tests / Cell Proliferation / Structure activity Relationship / Erythrocytes / Molecular Structure / Hemolysis

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N -Arylalkyl Pseudopeptide Inhibitors of Farnesyltransferase

Organic Chemistry / Medicinal Chemistry / Enzyme Inhibitors / Cell Division / Prodrugs / Mice / Animals / T cells / Rats / Molecular Mimicry / Medicinal / Structure activity Relationship / Esters / Mice / Animals / T cells / Rats / Molecular Mimicry / Medicinal / Structure activity Relationship / Esters

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New Furan Side Tetracyclic Allopsoralen Derivatives: Synthesis and Photobiological Evaluation

Organic Chemistry / Medicinal Chemistry / Humans / Darkness / Animals / Polymerase Chain Reaction / Skin / Medicinal / Toxicity Tests / Structure activity Relationship / Antineoplastic Agents / Furans / "Intercalating Agents" / Polymerase Chain Reaction / Skin / Medicinal / Toxicity Tests / Structure activity Relationship / Antineoplastic Agents / Furans / "Intercalating Agents"

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Discovery of 5-[[4-[(2,3-Dimethyl-2 H -indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor †

Organic Chemistry / Medicinal Chemistry / Pharmacokinetics / Macromolecular X-Ray Crystallography / Cell line / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor

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