Medicinal Chemistry

N -Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds

Pharmacology / Chemistry / Organic Chemistry / Pharmacy / Medicinal Chemistry / Malaria / Humans / Animals / Rats / Hepatocytes / Plasmodium falciparum / Antimalarials / Benzimidazoles / Structure activity Relationship / Plasmodium berghei / Malaria / Humans / Animals / Rats / Hepatocytes / Plasmodium falciparum / Antimalarials / Benzimidazoles / Structure activity Relationship / Plasmodium berghei

2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 2

Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents

2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 1

Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents

Branched Diacylglycerol-Lactones as Potent Protein Kinase C Ligands and α-Secretase Activators

Organic Chemistry / Medicinal Chemistry / Humans / Animals / Rats / Structure activity Relationship / Protein Binding / Diglycerides / Ligands / Lactones / Structure activity Relationship / Protein Binding / Diglycerides / Ligands / Lactones

2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 2

Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents

2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 1

Medicinal Chemistry / Magnetic Resonance Spectroscopy / RNA viruses / HIV / Humans / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents / Animals / C2H2 zinc fingers / Regression Analysis / Medicinal / Cell Proliferation / Benzimidazoles / Quntitative Thin Layer Chromatography / Structure activity Relationship / Antineoplastic Agents / Flaviviridae / Antiviral Agents

(Hetero)aroyl esters of 2-(N-phthalimido)ethanol and analogues: parallel synthesis, anti-HIV-1 activity and cytotoxicity

Medicinal Chemistry / Enzyme

Preparation and Pharmacological Characterization of trans -2-Amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1 H -indenes as D 2 -like Dopamine Receptor Agonists

Organic Chemistry / Medicinal Chemistry / cyclic AMP / Animals / dopamine receptor D4 / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Microbiology / Medicinal Chemistry / Molecular Biology / Biology / Malaria / Enzyme Inhibitors / Public Health / Biological Sciences / Humans / Protease / Endoplasmic Reticulum / Host Parasite Interaction / Protozoan Proteins / Erythrocytes / Protein Transport / Enzyme Inhibitors / Public Health / Biological Sciences / Humans / Protease / Endoplasmic Reticulum / Host Parasite Interaction / Protozoan Proteins / Erythrocytes / Protein Transport

Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic? -

Medicinal Chemistry / Medicinal chemistry and pharmaceutical chemistry / Medicinal Chemistry, Drug Discovery, Molecular modeling, Computer aided drug design (CADD) / Pharmacogenomics Antiepileptic drugs / Mesial Temporal Sclerosis / Antiepileptic drugs / Antiepileptic Drug / Antiepileptic drugs / Antiepileptic Drug

Two-photon sensitive protecting groups operating via intramolecular electron transfer

Organic Chemistry / Biomedical Engineering / Medicinal Chemistry / Targeted Drug Delivery

Cytotoxic Activity of C -Geranyl Compounds from Paulownia tomentosa Fruits

Medicinal Chemistry / Complementary and Alternative Medicine / Plant Biology / Tobacco / Medicinal Plants / Cell Differentiation / Humans / Fruit / Phenols / Angiosperms / Cytotoxic Activity / Medicinal plant chemistry / Lethal Dose / Chromones / Planta / Cell Differentiation / Humans / Fruit / Phenols / Angiosperms / Cytotoxic Activity / Medicinal plant chemistry / Lethal Dose / Chromones / Planta

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators

Organic Chemistry / Medicinal Chemistry / Kinetics / Enzyme Inhibitors / Cell line / Humans / Mice / Animals / Drug Design / Medicinal / Neoplasms / Structure activity Relationship / Biological Availability / Antineoplastic Agents / Humans / Mice / Animals / Drug Design / Medicinal / Neoplasms / Structure activity Relationship / Biological Availability / Antineoplastic Agents

Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo

Organic Chemistry / Medicinal Chemistry / Calcium / Female / Animals / Male / Myocardial Infarction / Rabbits / Structure activity Relationship / Male / Myocardial Infarction / Rabbits / Structure activity Relationship

Fancy Bioisosteres: Novel Paracyclophane Derivatives As Super-Affinity Dopamine D3 Receptor Antagonists

Organic Chemistry / Medicinal Chemistry / Magnetic Resonance Spectroscopy / Dopamine / Humans / Mutation / Animals / Amides / Swine / Radioligand Assay / Medicinal / Molecular Conformation / Structure activity Relationship / Mutation / Animals / Amides / Swine / Radioligand Assay / Medicinal / Molecular Conformation / Structure activity Relationship

Cytotoxic Activity of C -Geranyl Compounds from Paulownia tomentosa Fruits

Medicinal Chemistry / Complementary and Alternative Medicine / Plant Biology / Tobacco / Medicinal Plants / Cell Differentiation / Humans / Fruit / Phenols / Angiosperms / Cytotoxic Activity / Medicinal plant chemistry / Lethal Dose / Chromones / Planta / Cell Differentiation / Humans / Fruit / Phenols / Angiosperms / Cytotoxic Activity / Medicinal plant chemistry / Lethal Dose / Chromones / Planta

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