Medicinal Chemistry

A Novel Cell-Penetrating Peptide Sequence Derived by Structural Minimization of a Snake Toxin Exhibits Preferential Nucleolar Localization

Organic Chemistry / Medicinal Chemistry / Snake venoms / Humans / Animals / HeLa cells / Medicinal / Amino Acid Sequence / Protein Transport / HeLa cells / Medicinal / Amino Acid Sequence / Protein Transport

Calixcephems: clustered cephalosporins analogous to calixpenams as novel potential anti-MRSA agents

Medicinal Chemistry / Bioorganic Chemistry

Chemometric Studies on Potential Larvicidal Compounds Against Aedes Aegypti

Medicinal Chemistry / Principal Component Analysis / Insecticides / Animals / Mosquito Control / Larva / Structure activity Relationship / Aedes / Molecular Structure / Larva / Structure activity Relationship / Aedes / Molecular Structure

De Novo Cyclic Pseudopeptides Containing Aza-β 3 -amino Acids Exhibiting Antimicrobial Activities

Organic Chemistry / Medicinal Chemistry / Peptidomimetics / Sheep / Animals / Cyclic peptides / Gram Positive Bacteria / Amino Acids / Gram-negative bacteria / Anti-Bacterial Agents / Microbial Sensitivity Tests / Structure activity Relationship / Hemolysis / Cyclic peptides / Gram Positive Bacteria / Amino Acids / Gram-negative bacteria / Anti-Bacterial Agents / Microbial Sensitivity Tests / Structure activity Relationship / Hemolysis

Antimalarial Pyrido[1,2- a ]benzimidazoles

Organic Chemistry / Medicinal Chemistry / Malaria / Humans / Mice / Animals / Male / Rats / Plasmodium falciparum / Antimalarials / Pyridines / Benzimidazoles / Structure activity Relationship / Plasmodium berghei / Animals / Male / Rats / Plasmodium falciparum / Antimalarials / Pyridines / Benzimidazoles / Structure activity Relationship / Plasmodium berghei

Polarographic and Pharmacological study of Zn (II)-Paracetamol complex

Pharmacology / Medicinal Chemistry / Polarography

Aminoacyl-tRNA synthetase inhibitors as potential antibiotics

Organic Chemistry / Medicinal Chemistry / Drug Discovery / Enzyme Inhibitors / Humans / Animals / Anti-Bacterial Agents / Animals / Anti-Bacterial Agents

In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity

Organic Chemistry / Medicinal Chemistry / Obesity / Pharmaceutical Chemistry / Dogs / Humans / Animals / Drug Design / Enzyme / Food intake / Rats / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Carbamates / Humans / Animals / Drug Design / Enzyme / Food intake / Rats / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Carbamates

5-Benzylidene 1,2-Dihydrochromeno[3,4- f ]quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Progesterone / Humans / Female / Animals / Rats / Medicinal / Quinolines / Structure activity Relationship / Uterus / Ovariectomy / Female / Animals / Rats / Medicinal / Quinolines / Structure activity Relationship / Uterus / Ovariectomy

5-Aryl-1,2-dihydrochromeno[3,4- f ]quinolines: A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists

Organic Chemistry / Medicinal Chemistry / Magnetic Resonance Spectroscopy / Humans / Female / Animals / Rats / Medicinal / Quinolines / Structure activity Relationship / Uterus / Animals / Rats / Medicinal / Quinolines / Structure activity Relationship / Uterus

Preparation and Pharmacological Characterization of trans -2-Amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1 H -indenes as D 2 -like Dopamine Receptor Agonists

Organic Chemistry / Medicinal Chemistry / cyclic AMP / Animals / dopamine receptor D4 / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP

Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Dogs / Humans / Blood brain barrier / Animals / Drug Design / Rats / Pyrazoles / Structure activity Relationship / cyclic GMP / Molecular Structure / Blood brain barrier / Animals / Drug Design / Rats / Pyrazoles / Structure activity Relationship / cyclic GMP / Molecular Structure

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Microbiology / Medicinal Chemistry / Molecular Biology / Biology / Malaria / Enzyme Inhibitors / Public Health / Biological Sciences / Humans / Protease / Endoplasmic Reticulum / Host Parasite Interaction / Protozoan Proteins / Erythrocytes / Protein Transport / Enzyme Inhibitors / Public Health / Biological Sciences / Humans / Protease / Endoplasmic Reticulum / Host Parasite Interaction / Protozoan Proteins / Erythrocytes / Protein Transport

Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1 H-pyrrolo[1,2- c]imidazol-1-ones: A new class of Neuropeptide S antagonists

Inorganic Chemistry / Organic Chemistry / Medicinal Chemistry / Calcium / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure

N -Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds

Pharmacology / Chemistry / Organic Chemistry / Pharmacy / Medicinal Chemistry / Malaria / Humans / Animals / Rats / Hepatocytes / Plasmodium falciparum / Antimalarials / Benzimidazoles / Structure activity Relationship / Plasmodium berghei / Malaria / Humans / Animals / Rats / Hepatocytes / Plasmodium falciparum / Antimalarials / Benzimidazoles / Structure activity Relationship / Plasmodium berghei

ANTI-MICROBIAL POTENTIAL OF ELEPHANTOPUS SCABER: AN UPDATE REVIEW

Medicinal Chemistry / Natural Products Chemistry / Phytochemistry / Medicinal Plants / Pharmacognosy and Phytochemistry / Solvent Extraction / Isolation / Solvent Extraction / Isolation

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