Gene Silencing

Differential fates of biomolecules delivered to target cells via extracellular vesicles

Flow Cytometry / Fluorescence Microscopy / Confocal Microscopy / Atomic Force Microscopy / Apoptosis / Multidisciplinary / Gene Silencing / DNA / Lipids / Humans / Mice / Animals / Exosomes / Plasmids / Cell communication / Polyethylene Glycols / Multidisciplinary / Gene Silencing / DNA / Lipids / Humans / Mice / Animals / Exosomes / Plasmids / Cell communication / Polyethylene Glycols

INCREASED SIZE EXCLUSION LIMIT2 Encodes a Putative DEVH Box RNA Helicase Involved in Plasmodesmata Function during Arabidopsis Embryogenesis

Genetics / Plant Biology / Plasmodesmata / Gene expression / Gene Silencing / Protein Structure and Function / Mutation / Arabidopsis / Phenotype / Molecular cloning / microRNAs / Embryonic Development / Seeds / Seedling / Biological markers / Plant cell / Subcellular Fractions / Cell Fate / Embryos / Protein Transport / Biochemistry and cell biology / Down-Regulation / Protein Structure and Function / Mutation / Arabidopsis / Phenotype / Molecular cloning / microRNAs / Embryonic Development / Seeds / Seedling / Biological markers / Plant cell / Subcellular Fractions / Cell Fate / Embryos / Protein Transport / Biochemistry and cell biology / Down-Regulation

Positive Cross-Regulatory Loop Ties GATA-3 to Estrogen Receptor Expression in Breast Cancer

Cancer / Breast Cancer / Gene Silencing / Estrogen Receptor / Humans / Estradiol / Estrogen receptor alpha / Estradiol / Estrogen receptor alpha

Positive Cross-Regulatory Loop Ties GATA3 to Estrogen Receptor A Expression in Breast Cancer

Cancer / Breast Cancer / Cell Cycle / Gene Silencing / Humans / Transcription Factor / Mammary gland / Estradiol / Breast Cancer Cells / Estrogen receptor alpha / Transcription Factor / Mammary gland / Estradiol / Breast Cancer Cells / Estrogen receptor alpha

X-Prolyl Dipeptidyl Aminopeptidase Gene (pepX) Is Part of the glnRA Operon in Lactobacillus rhamnosus

Bacteriology / Sequence Analysis / Gene Silencing / Biological Sciences / Lactobacillus / Molecular cloning / Amino Acid Sequence / Base Sequence / DNA binding proteins / Molecular cloning / Amino Acid Sequence / Base Sequence / DNA binding proteins

Gene loss and silencing in Tragopogon miscellus (Asteraceae): comparison of natural and synthetic allotetraploids

Evolutionary Biology / Genetics / Gene Silencing / Polyploidy / Heredity / Plant Genome Project

Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency

Algorithms / Thermodynamics / RNA / Biotechnology / RNA silencing / Multidisciplinary / Gene Silencing / Nature / RNA interference / Cell line / Humans / Plasmids / microRNAs / Secondary Structure / Degeneration / RNA Structure / Structure Determination / RNA Secondary Structure / Nucleic Acid Conformation / Nucleotides / Multidisciplinary / Gene Silencing / Nature / RNA interference / Cell line / Humans / Plasmids / microRNAs / Secondary Structure / Degeneration / RNA Structure / Structure Determination / RNA Secondary Structure / Nucleic Acid Conformation / Nucleotides

Lysyl Oxidase (Lox) Gene Deficiency Affects Osteoblastic Phenotype

Biomedical Engineering / Structural Integrity / Apoptosis / Gene Silencing / DNA / Cell Differentiation / Mice / Animals / Skull / Osteopontin / Phenotype / Calcified tissue / Clinical Sciences / mRna expression levels / Isoenzymes / Osteoblasts / Biochemistry and cell biology / Down-Regulation / lysyl oxidase / Dna Synthesis / DNA fragmentation / Type I Collagen / Cell Differentiation / Mice / Animals / Skull / Osteopontin / Phenotype / Calcified tissue / Clinical Sciences / mRna expression levels / Isoenzymes / Osteoblasts / Biochemistry and cell biology / Down-Regulation / lysyl oxidase / Dna Synthesis / DNA fragmentation / Type I Collagen

Farnesoid X receptor represses hepatic lipase gene expression

RNA / Transcription Factors / Gene expression / Gene Silencing / Cell line / Humans / Liver / Lipid metabolism / Lipoprotein(a) / Enzyme / Cell nucleus / Time Dependent / Time Factors / Hepatocytes / Lipoproteins / High Density Lipoprotein / Transfection / Lipid / Enzymatic Activity / DNA binding proteins / Lipase / Ligands / Biochemistry and cell biology / Down-Regulation / Humans / Liver / Lipid metabolism / Lipoprotein(a) / Enzyme / Cell nucleus / Time Dependent / Time Factors / Hepatocytes / Lipoproteins / High Density Lipoprotein / Transfection / Lipid / Enzymatic Activity / DNA binding proteins / Lipase / Ligands / Biochemistry and cell biology / Down-Regulation

In Vivo Activation of a Conserved MicroRNA Program Induces Mammalian Heart Regeneration

Regeneration / Stem Cell / Gene Silencing / Mammals / Biological Sciences / Humans / Animals / Heart / Genome / microRNAs / Myocardium / Zebrafish / Cell Proliferation / Down-Regulation / Humans / Animals / Heart / Genome / microRNAs / Myocardium / Zebrafish / Cell Proliferation / Down-Regulation

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways

Membrane Proteins / Apoptosis / Gene Silencing / Humans / Paclitaxel / Anthracyclines / Protein Binding / Antineoplastic Agents / Endosomes / Ceramides / Biochemistry and cell biology / Anthracyclines / Protein Binding / Antineoplastic Agents / Endosomes / Ceramides / Biochemistry and cell biology

Faciogenital Dysplasia Protein (FGD1) Regulates Export of Cargo Proteins from the Golgi Complex via Cdc42 Activation

Molecular Biology / Gene Silencing / Biological Sciences / Cell line / Humans / Mice / Animals / Proteins / Molecular Mimicry / Osteoblasts / Golgi Apparatus / Protein Binding / Protein Transport / Mice / Animals / Proteins / Molecular Mimicry / Osteoblasts / Golgi Apparatus / Protein Binding / Protein Transport

Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status

Gene Silencing / Energy Metabolism / Biological Sciences / DNA / Cell line / Humans / Glucose / Cell / Cell Death / Sirtuins / Histones / NAD / Sirtuin / Humans / Glucose / Cell / Cell Death / Sirtuins / Histones / NAD / Sirtuin

BCL6 represses NFκB activity in diffuse large B-cell lymphomas

Pathology / Gene Silencing / Humans / C2H2 zinc fingers / NF-kappa B / Clinical Sciences / HeLa cells / Diffuse Large B-Cell Lymphoma / Clinical Sciences / HeLa cells / Diffuse Large B-Cell Lymphoma

A Novel Artificial MicroRNA Expressing AAV Vector for Phospholamban Silencing in Cardiomyocytes Improves Ca2+ Uptake into the Sarcoplasmic Reticulum

Inflammation / Calcium / Proteomics / Multidisciplinary / Gene Silencing / Western blotting / Humans / Animals / PLoS one / microRNAs / Myocardium / Reproducibility of Results / Wistar Rats / Calcium Binding Proteins / Sarcoplasmic reticulum / Western blotting / Humans / Animals / PLoS one / microRNAs / Myocardium / Reproducibility of Results / Wistar Rats / Calcium Binding Proteins / Sarcoplasmic reticulum

An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

Genomics / Multidisciplinary / Gene Silencing / Nature / Cell Division / RNA interference / Mitosis / Video microscopy / Humans / Cell Viability / Phenotype / Gene Function / HeLa cells / Very high throughput / Cytokinesis / Cell Proliferation / Cell Survival / RNA interference / Mitosis / Video microscopy / Humans / Cell Viability / Phenotype / Gene Function / HeLa cells / Very high throughput / Cytokinesis / Cell Proliferation / Cell Survival

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