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Gene Silencing
Gene Silencing
Neuroblastoma-targeted Nanoparticles Entrapping siRNA Specifically Knockdown ALK
Pharmacology / Technology / Nanoparticles / Gene Silencing / Western blotting / Biological Sciences / Molecular / RNA interference / Cell line / Humans / Mice / Animals / Therapy / Cell Death / Neuroblastoma / Delivery System / Anaplastic Lymphoma Kinase (ALK) / Transfection / Side Effect / Antitumor Activity / Molecular Targeted Therapy / Receptor Tyrosine Kinase / Cell Growth / Biological Sciences / Molecular / RNA interference / Cell line / Humans / Mice / Animals / Therapy / Cell Death / Neuroblastoma / Delivery System / Anaplastic Lymphoma Kinase (ALK) / Transfection / Side Effect / Antitumor Activity / Molecular Targeted Therapy / Receptor Tyrosine Kinase / Cell Growth
In vivo therapeutic efficacy of intra-renal CD40 silencing in a model of humoral acute rejection
Immune response / Nonparametric Statistics / Gene Therapy / Kidney transplantation / Immunohistochemistry / Gene Silencing / Biological Sciences / Antibodies / Renal transplantation / Animals / Male / Polymerase Chain Reaction / Rats / Kidney Transplant / Wistar Rats / Combination drug therapy / Graft Rejection / Sirolimus / Acute rejection / Gene Silencing / Biological Sciences / Antibodies / Renal transplantation / Animals / Male / Polymerase Chain Reaction / Rats / Kidney Transplant / Wistar Rats / Combination drug therapy / Graft Rejection / Sirolimus / Acute rejection
Loss of Protein Kinase PKR Expression in Human HeLa Cells Complements the Vaccinia Virus E3L Deletion Mutant Phenotype by Restoration of Viral Protein Synthesis
Virology / Apoptosis / Gene Silencing / Protein synthesis / Biological Sciences / RNA interference / Humans / Mutation / Virus / Phosphorylation / Phenotype / RNA-binding proteins / HeLa cells / Vaccinia Virus / Complement / Protein Kinase / double-stranded RNA / RNA interference / Humans / Mutation / Virus / Phosphorylation / Phenotype / RNA-binding proteins / HeLa cells / Vaccinia Virus / Complement / Protein Kinase / double-stranded RNA
Class-, gene-, and group-specific HLA silencing by lentiviral shRNA delivery
Molecular Medicine / Gene Therapy / Regenerative Medicine / Gene Silencing / RNA interference / Cell line / Humans / Natural Killer cells / Lentivirus / T lymphocytes / B Lymphocytes / Immune Tolerance / Cell free System / NK Cell / In Vitro Transcription / Interferon gamma / Cell line / Humans / Natural Killer cells / Lentivirus / T lymphocytes / B Lymphocytes / Immune Tolerance / Cell free System / NK Cell / In Vitro Transcription / Interferon gamma
Systems Virology Identifies a Mitochondrial Fatty Acid Oxidation Enzyme, Dodecenoyl Coenzyme A Delta Isomerase, Required for Hepatitis C Virus Replication and Likely Pathogenesis
Virology / Mitochondria / Gene Silencing / Biopsy / Biological Sciences / Cell line / Humans / Liver / Fatty acids / Hepatocytes / Host Pathogen Interactions / Proteome / Oxidation-Reduction / Cell line / Humans / Liver / Fatty acids / Hepatocytes / Host Pathogen Interactions / Proteome / Oxidation-Reduction
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
Cell Cycle / DNA damage / Transcription Factors / Apoptosis / Gene Silencing / Mice / Methylation / Animals / B Lymphocytes / Clinical Investigation / Germinal Center / Mice / Methylation / Animals / B Lymphocytes / Clinical Investigation / Germinal Center
MicroRNA-196a Is a Potential Marker of Progression during Barrett\'s Metaplasia-Dysplasia-Invasive Adenocarcinoma Sequence in Esophagus
Micro Rna / MicroRNA / Cancer / Gene Silencing / RNA interference / Humans / Female / Male / American / Keratin / Sequence / Aged / Middle Aged / microRNAs / Neoplasm Invasiveness / Adult / Esophagus / Retrospective Studies / Disease Progression / Adenocarcinoma / Humans / Female / Male / American / Keratin / Sequence / Aged / Middle Aged / microRNAs / Neoplasm Invasiveness / Adult / Esophagus / Retrospective Studies / Disease Progression / Adenocarcinoma
MicroRNA-196a Is a Potential Marker of Progression during Barrett\'s Metaplasia-Dysplasia-lnvasive Adenocarcinoma Sequence in Esophagus
Micro Rna / MicroRNA / Cancer / Gene Silencing / RNA interference / Humans / Female / Male / American / Keratin / Sequence / Aged / Middle Aged / microRNAs / Neoplasm Invasiveness / Adult / Esophagus / Retrospective Studies / Disease Progression / Adenocarcinoma / Humans / Female / Male / American / Keratin / Sequence / Aged / Middle Aged / microRNAs / Neoplasm Invasiveness / Adult / Esophagus / Retrospective Studies / Disease Progression / Adenocarcinoma
Cardiac glycosides correct aberrant splicing of IKBKAP -encoded mRNA in familial dysautonomia derived cells by suppressing expression of SRSF3
Gene Silencing / Cell line / Humans / Alternative splicing / RNA-binding proteins / Alternative Splicing / Base Sequence / Digoxin / Biochemistry and cell biology / Alternative Splicing / Base Sequence / Digoxin / Biochemistry and cell biology
Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation
Cancer Biology / Gene Silencing / Humans / Multiple Myeloma / DNA methylation / Superoxide Dismutase / Cell Proliferation / Superoxide Dismutase / Cell Proliferation
Lysyl Oxidase (Lox) Gene Deficiency Affects Osteoblastic Phenotype
Biomedical Engineering / Structural Integrity / Apoptosis / Gene Silencing / DNA / Cell Differentiation / Mice / Animals / Skull / Osteopontin / Phenotype / Calcified tissue / Clinical Sciences / mRna expression levels / Isoenzymes / Osteoblasts / Biochemistry and cell biology / Down-Regulation / lysyl oxidase / Dna Synthesis / DNA fragmentation / Type I Collagen / Cell Differentiation / Mice / Animals / Skull / Osteopontin / Phenotype / Calcified tissue / Clinical Sciences / mRna expression levels / Isoenzymes / Osteoblasts / Biochemistry and cell biology / Down-Regulation / lysyl oxidase / Dna Synthesis / DNA fragmentation / Type I Collagen
A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo
Flow Cytometry / Multidisciplinary / Gene Silencing / Metabolic syndrome / Cell line / Humans / Mice / Animals / Cell Death / Polymerase Chain Reaction / PLoS one / LDL-cholesterol / Cardiovascular Risk Factor / Alanine Aminotransferase / Antisense Oligonucleotide Drugs / Familial Hypercholesterolemia / Cell Survival / Low Density Lipoprotein (LDL) / Intracellular Space / Oligonucleotides / Humans / Mice / Animals / Cell Death / Polymerase Chain Reaction / PLoS one / LDL-cholesterol / Cardiovascular Risk Factor / Alanine Aminotransferase / Antisense Oligonucleotide Drugs / Familial Hypercholesterolemia / Cell Survival / Low Density Lipoprotein (LDL) / Intracellular Space / Oligonucleotides
Extracellular Alkaline pH Leads to Increased Metastatic Potential of Estrogen Receptor Silenced Endocrine Resistant Breast Cancer Cells
Multidisciplinary / Gene Silencing / Signal Transduction / Humans / Female / PLoS one / Matrix Metalloproteinases / Cell Proliferation / Hydrogen-Ion Concentration / Extracellular Space / Intracellular Space / PLoS one / Matrix Metalloproteinases / Cell Proliferation / Hydrogen-Ion Concentration / Extracellular Space / Intracellular Space
GATA-4 and GATA-5 Transcription Factor Genes and Potential Downstream Antitumor Target Genes Are Epigenetically Silenced in Colorectal and Gastric Cancer
Genetics / Cellular Biology / Transcription Factors / Gene expression / Gene Silencing / Colorectal cancer / Biological Sciences / Molecular and cellular biology / Humans / Gastric Cancer / DNA methylation / CpG islands / Gene Selection / Transcription Factor / Oncogenes / DNA binding proteins / Colorectal Neoplasms / Colorectal cancer / Biological Sciences / Molecular and cellular biology / Humans / Gastric Cancer / DNA methylation / CpG islands / Gene Selection / Transcription Factor / Oncogenes / DNA binding proteins / Colorectal Neoplasms
GATA-4 and GATA-5 Transcription Factor Genes and Potential Downstream Antitumor Target Genes Are Epigenetically Silenced in Colorectal and Gastric Cancer
Genetics / Cellular Biology / Transcription Factors / Gene expression / Gene Silencing / Colorectal cancer / Biological Sciences / Molecular and cellular biology / Humans / Gastric Cancer / DNA methylation / CpG islands / Gene Selection / Transcription Factor / Oncogenes / DNA binding proteins / Colorectal Neoplasms / Colorectal cancer / Biological Sciences / Molecular and cellular biology / Humans / Gastric Cancer / DNA methylation / CpG islands / Gene Selection / Transcription Factor / Oncogenes / DNA binding proteins / Colorectal Neoplasms
Virus-induced gene silencing (VIGS) in Cysticapnos vesicaria, a zygomorphic-flowered Papaveraceae (Ranunculales, basal eudicots)
Reproduction / Plant Biology / Ecology / Gene Silencing / Inflorescence / Oxidoreductases / Fruit / Phenotype / Plant viruses / Genotype / PLANT PROTEINS / Meristem / Plant Leaves / Down-Regulation / Oxidoreductases / Fruit / Phenotype / Plant viruses / Genotype / PLANT PROTEINS / Meristem / Plant Leaves / Down-Regulation
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