Down-Regulation

Paradoxical microRNAs: Individual gene repressors, global translation enhancers

Cell Cycle / RNA interference / Humans / microRNAs / Human Fibroblasts / Protein Biosynthesis / Biochemistry and cell biology / Down-Regulation / Protein Biosynthesis / Biochemistry and cell biology / Down-Regulation

Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer

Engineering / Genetics / Pathology / Physics / Chemistry / Immunology / Genomics / Metabolism / Biology / Wound Healing / Medicine / Multidisciplinary / Epithelial-Mesenchymal Transition / Transcriptome / Endometrial Cancer / Cell line / Progesterone / Humans / Female / PLoS one / Aged / Middle Aged / Pathway Analysis / Retrospective Studies / Protein Expression / Disease Progression / Genetic Analysis / Genetic Association / Retrospective Study / Expression analysis / Epithelial to Mesenchymal Transition / Down-Regulation / Immunology / Genomics / Metabolism / Biology / Wound Healing / Medicine / Multidisciplinary / Epithelial-Mesenchymal Transition / Transcriptome / Endometrial Cancer / Cell line / Progesterone / Humans / Female / PLoS one / Aged / Middle Aged / Pathway Analysis / Retrospective Studies / Protein Expression / Disease Progression / Genetic Analysis / Genetic Association / Retrospective Study / Expression analysis / Epithelial to Mesenchymal Transition / Down-Regulation

Intracellular mRNA cleavage induced through activation of RNase P by nuclease-resistant external guide sequences

Multidisciplinary / Nature / Western blotting / Cell line / Humans / tRNA / Therapy / Substrate Specificity / Isoenzymes / Transfection / Nucleic Acid Conformation / Down-Regulation / tRNA / Therapy / Substrate Specificity / Isoenzymes / Transfection / Nucleic Acid Conformation / Down-Regulation

Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo

Transgenic Mice / Signal Transduction / Cell line / Humans / Blood Glucose / Insulin / Fasting / Mice / Animals / Male / P-glycoprotein / Insulin signaling / Animal Model / Phosphorylation / European / Time Factors / Hepatocytes / Genetic Polymorphism / Transfection / Insulin Receptor / Type 2 Diabetes Mellitus / Tyrosine / Tyrosine Phosphorylation / Down-Regulation / Insulin / Fasting / Mice / Animals / Male / P-glycoprotein / Insulin signaling / Animal Model / Phosphorylation / European / Time Factors / Hepatocytes / Genetic Polymorphism / Transfection / Insulin Receptor / Type 2 Diabetes Mellitus / Tyrosine / Tyrosine Phosphorylation / Down-Regulation

Down regulation of brain cellular prion protein in an animal model of insulin resistance: possible implication in increased prevalence of stroke in pre-diabetics/diabetics

Insulin Resistance / Stroke / Brain / Animals / Male / Phosphorylation / Fructose / Rats / Diabetes complications / Biochemistry and cell biology / Down-Regulation / Phosphorylation / Fructose / Rats / Diabetes complications / Biochemistry and cell biology / Down-Regulation

Macrophage Inflammatory Protein 1  Inhibits Postentry Steps of Human Immunodeficiency Virus Type 1 Infection via Suppression of Intracellular Cyclic AMP

Virology / HIV / Biological Sciences / Humans / cyclic AMP / Human immunodeficiency virus / Down-Regulation / Human immunodeficiency virus / Down-Regulation

Macrophage inflammatory protein 1alpha inhibits postentry steps of human immunodeficiency virus type 1 infection via suppression of intracellular cyclic AMP

Virology / HIV / Biological Sciences / Humans / cyclic AMP / Human immunodeficiency virus / Down-Regulation / Human immunodeficiency virus / Down-Regulation

Loss of Anterior Gradient-2 expression is an independent prognostic factor in colorectal carcinomas

Immunohistochemistry / Adolescent / Multivariate Analysis / RNA interference / Humans / Young Adult / Proteins / Risk factors / Aged / Middle Aged / Caco-2 cells / Carcinoma / Adult / Time Factors / Chi Square Distribution / Risk Factors / Transfection / Proportional Hazards Models / Down-Regulation / Young Adult / Proteins / Risk factors / Aged / Middle Aged / Caco-2 cells / Carcinoma / Adult / Time Factors / Chi Square Distribution / Risk Factors / Transfection / Proportional Hazards Models / Down-Regulation

Loss of Anterior Gradient-2 expression is an independent prognostic factor in colorectal carcinomas

Immunohistochemistry / Adolescent / Multivariate Analysis / RNA interference / Humans / Young Adult / Proteins / Risk factors / Aged / Middle Aged / Caco-2 cells / Carcinoma / Adult / Time Factors / Chi Square Distribution / Risk Factors / Transfection / Proportional Hazards Models / Down-Regulation / Young Adult / Proteins / Risk factors / Aged / Middle Aged / Caco-2 cells / Carcinoma / Adult / Time Factors / Chi Square Distribution / Risk Factors / Transfection / Proportional Hazards Models / Down-Regulation

FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma

Apoptosis / Signal Transduction / Caspases / Cell line / Humans / Chronic Lymphocytic Leukemia / Mice / Animals / Blood / Organ Transplantation / Clinical Sciences / Mouse Model / Cysteine endopeptidases / B Lymphocytes / Okadaic acid / Sphingosine / Down-Regulation / Chronic Lymphocytic Leukemia / Mice / Animals / Blood / Organ Transplantation / Clinical Sciences / Mouse Model / Cysteine endopeptidases / B Lymphocytes / Okadaic acid / Sphingosine / Down-Regulation

Epithelial-mesenchymal transition downregulates laminin α5 chain and upregulates laminin α4 chain in oral squamous carcinoma cells

Cell Adhesion / Transcription Factors / Epithelial-Mesenchymal Transition / Cell Differentiation / Humans / Basement Membrane / Female / Transcription Factor / Aged / Oral Squamous Cell Carcinoma (OSCC) / Neoplasm Invasiveness / Mouth Neoplasms / Epithelial cells / Chromatin Immunoprecipitation / Oral Squamous Cell Carcinoma / Protein Binding / Mesenchymal Stromal Cells / Extracellular Matrix Proteins / Down-Regulation / Basement Membrane / Female / Transcription Factor / Aged / Oral Squamous Cell Carcinoma (OSCC) / Neoplasm Invasiveness / Mouth Neoplasms / Epithelial cells / Chromatin Immunoprecipitation / Oral Squamous Cell Carcinoma / Protein Binding / Mesenchymal Stromal Cells / Extracellular Matrix Proteins / Down-Regulation

Mutant Cu/Zn-Superoxide Dismutase Associated with Amyotrophic Lateral Sclerosis Destabilizes Vascular Endothelial Growth Factor mRNA and Downregulates Its Expression

Neuroscience / Amyotrophic Lateral Sclerosis / Mice / Animals / Superoxide Dismutase / RNA-binding proteins / Amino Acid Substitution Rates / Vascular Endothelial Growth Factor / Down-Regulation / RNA-binding proteins / Amino Acid Substitution Rates / Vascular Endothelial Growth Factor / Down-Regulation

Mutant Cu/Zn-Superoxide Dismutase Associated with Amyotrophic Lateral Sclerosis Destabilizes Vascular Endothelial Growth Factor mRNA and Downregulates Its Expression

Neuroscience / Amyotrophic Lateral Sclerosis / Mice / Animals / Superoxide Dismutase / RNA-binding proteins / Amino Acid Substitution Rates / Vascular Endothelial Growth Factor / Down-Regulation / RNA-binding proteins / Amino Acid Substitution Rates / Vascular Endothelial Growth Factor / Down-Regulation

Natural killer clones recognize specific soluble HLA class I molecules

Immunology / Innate immunity / Humans / Natural Killer cells / Solubility / European / Down-Regulation / European / Down-Regulation

Lactobacillus casei downregulates commensalsʼ inflammatory signals in Crohnʼs disease mucosa

Inflammation / Signal Transduction / Inflammatory Bowel Disease / Humans / Intestinal Mucosa / Escherichia coli / Female / Male / Clinical Sciences / Lactobacillus Casei / Adult / Crohn Disease / Inflammatory Bowel Diseases / Down-Regulation / Escherichia coli / Female / Male / Clinical Sciences / Lactobacillus Casei / Adult / Crohn Disease / Inflammatory Bowel Diseases / Down-Regulation

STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas

Breast Cancer / Transcriptome / Humans / Mice / Female / Animals / Cluster Analysis / Epithelial cells / Retrospective Studies / DNA binding proteins / Adenocarcinoma / Down-Regulation / Estrogen receptor alpha / Animals / Cluster Analysis / Epithelial cells / Retrospective Studies / DNA binding proteins / Adenocarcinoma / Down-Regulation / Estrogen receptor alpha
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