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In Vitro
In Vitro
Discovery of 5-[[4-[(2,3-Dimethyl-2 H -indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor †
Organic Chemistry / Medicinal Chemistry / Pharmacokinetics / Macromolecular X-Ray Crystallography / Cell line / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor
Antimalarial Agents from Plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva
Complementary and Alternative Medicine / Plant Biology / Pharmacognosy / In Vitro / Animals / STEM / Araceae / Ficus / Bark / Isolation / Plant extracts / Plasmodium falciparum / Antimalarials / Biological activity / Extract / Active Ingredient / Planta / Molecular Structure / Plant Leaves / Terpenoid / STEM / Araceae / Ficus / Bark / Isolation / Plant extracts / Plasmodium falciparum / Antimalarials / Biological activity / Extract / Active Ingredient / Planta / Molecular Structure / Plant Leaves / Terpenoid
Reversal of Adriamycin Resistance by Recombinant α-Interferon in Multidrug-resistant Human Colon Carcinoma LoVo-Doxorubicin Cells
Cancer / Cell Cycle / Cytotoxicity / Gene expression / Cell Division / In Vitro / Humans / Drug Resistance / Doxorubicin / Drug Interaction / Recombinant Proteins / Adenocarcinoma / In Vitro / Humans / Drug Resistance / Doxorubicin / Drug Interaction / Recombinant Proteins / Adenocarcinoma
Evaluación De La Promoción Del Crecimiento De Cynodon Dactylon L. Por Rizobacterias Productoras De Fitohormonas Aisladas De Un Suelo Contaminado Con Hidrocarburos Derivados Del Petróleo
In Vitro / Plant Growth Promoting Rhizobacteria
HIV-1 integrase inhibitory substances fromColeus parvifolius
Traditional Medicine / Thailand / Pharmacognosy / HIV / Biological Sciences / Phytotherapy / In Vitro / Humans / Virus / Flowers / Fruit / Plant Roots / CHEMICAL SCIENCES / Plant extracts / Seeds / Microbial Sensitivity Tests / Integrase / Biological activity / Mixture / HIV Integrase / Plant Leaves / Phytotherapy / In Vitro / Humans / Virus / Flowers / Fruit / Plant Roots / CHEMICAL SCIENCES / Plant extracts / Seeds / Microbial Sensitivity Tests / Integrase / Biological activity / Mixture / HIV Integrase / Plant Leaves
HIV-1 integrase inhibitory substances fromColeus parvifolius
Traditional Medicine / Thailand / Pharmacognosy / HIV / Biological Sciences / Phytotherapy / In Vitro / Humans / Virus / Flowers / Fruit / Plant Roots / CHEMICAL SCIENCES / Plant extracts / Seeds / Microbial Sensitivity Tests / Integrase / Biological activity / Mixture / HIV Integrase / Plant Leaves / Phytotherapy / In Vitro / Humans / Virus / Flowers / Fruit / Plant Roots / CHEMICAL SCIENCES / Plant extracts / Seeds / Microbial Sensitivity Tests / Integrase / Biological activity / Mixture / HIV Integrase / Plant Leaves
Gamma Interferon Loaded onto Albumin Nanoparticles: In Vitro and In Vivo Activities against Brucella abortus
Microbiology / Medical Microbiology / Nanoparticle / Macrophages / Pharmaceutical Chemistry / In Vitro / Humans / Albumin / Mice / Nitric oxide / Animals / Bacteria / Nanostructures / Brucellosis / In Vivo / Delivery System / Charge / Antimicrobial agents / Biological activity / Drug Carriers / Brucella abortus / Interferon gamma / In Vitro / Humans / Albumin / Mice / Nitric oxide / Animals / Bacteria / Nanostructures / Brucellosis / In Vivo / Delivery System / Charge / Antimicrobial agents / Biological activity / Drug Carriers / Brucella abortus / Interferon gamma
Studies on quinones. Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents
Organic Chemistry / Cytotoxicity / Cell line / In Vitro / Humans / Quinones / Nitrogen / European / Biological activity / Antitumor Activity / Human Fibroblasts / Structure activity Relationship / Chemical Synthesis / Cell Survival / Antineoplastic Agents / Regioselectivity / Molecular Structure / aniline Compounds / Quinones / Nitrogen / European / Biological activity / Antitumor Activity / Human Fibroblasts / Structure activity Relationship / Chemical Synthesis / Cell Survival / Antineoplastic Agents / Regioselectivity / Molecular Structure / aniline Compounds
Studies on quinones. Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents
Organic Chemistry / Cytotoxicity / Cell line / In Vitro / Humans / Quinones / Nitrogen / European / Biological activity / Antitumor Activity / Human Fibroblasts / Structure activity Relationship / Chemical Synthesis / Cell Survival / Antineoplastic Agents / Regioselectivity / Molecular Structure / aniline Compounds / Quinones / Nitrogen / European / Biological activity / Antitumor Activity / Human Fibroblasts / Structure activity Relationship / Chemical Synthesis / Cell Survival / Antineoplastic Agents / Regioselectivity / Molecular Structure / aniline Compounds
Effect of Er,Cr:YSGG Laser and Professional Fluoride Application on Enamel Demineralization and on Fluoride Retention
Dentistry / Scanning Electron Microscopy / Solid state lasers / Ion selective electrodes / In Vitro / Humans / Fluorides / Hardness / Calcium Fluoride / Caries / Cariostatic Agents / Acidulated Phosphate Fluoride / Apatites / Laser Treatment / In Vitro Studies / Dental Enamel / Hydrogen-Ion Concentration / Humans / Fluorides / Hardness / Calcium Fluoride / Caries / Cariostatic Agents / Acidulated Phosphate Fluoride / Apatites / Laser Treatment / In Vitro Studies / Dental Enamel / Hydrogen-Ion Concentration
A novel sesquiterpene lactone from Centaurea pullata: Structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties
Organic Chemistry / Prediction / Pharmacokinetics / Pharmacognosy / Magnetic Resonance Spectroscopy / Structural Analysis / Cell line / In Vitro / Antimicrobial activity / Antifungal Activity / Sesquiterpenes / Antibacterial activity / Isolation / Structure Elucidation / Anti-Bacterial Agents / Water Solubility / ADME / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Microbial Viability / Centaurea / Lactones / Computational Method / Molecular Structure / Terpenoid / Structural Analysis / Cell line / In Vitro / Antimicrobial activity / Antifungal Activity / Sesquiterpenes / Antibacterial activity / Isolation / Structure Elucidation / Anti-Bacterial Agents / Water Solubility / ADME / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Microbial Viability / Centaurea / Lactones / Computational Method / Molecular Structure / Terpenoid
A novel sesquiterpene lactone from Centaurea pullata : Structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties
Organic Chemistry / Prediction / Pharmacokinetics / Pharmacognosy / Magnetic Resonance Spectroscopy / Structural Analysis / Cell line / In Vitro / Antimicrobial activity / Antifungal Activity / Sesquiterpenes / Antibacterial activity / Isolation / Structure Elucidation / Anti-Bacterial Agents / Water Solubility / ADME / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Microbial Viability / Centaurea / Lactones / Computational Method / Molecular Structure / Terpenoid / Structural Analysis / Cell line / In Vitro / Antimicrobial activity / Antifungal Activity / Sesquiterpenes / Antibacterial activity / Isolation / Structure Elucidation / Anti-Bacterial Agents / Water Solubility / ADME / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Microbial Viability / Centaurea / Lactones / Computational Method / Molecular Structure / Terpenoid
New imidazolidinedione derivatives as antimalarial agents
Organic Chemistry / Treatment / Prevention / In Vitro / Humans / Mice / Animals / Rhesus Monkey / Plasmodium falciparum / Antimalarials / Macaca Mulatta / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Mono / Plasmodium berghei / Molecular Structure / Mice / Animals / Rhesus Monkey / Plasmodium falciparum / Antimalarials / Macaca Mulatta / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Mono / Plasmodium berghei / Molecular Structure
New imidazolidinedione derivatives as antimalarial agents
Organic Chemistry / Treatment / Prevention / In Vitro / Humans / Mice / Animals / Rhesus Monkey / Plasmodium falciparum / Antimalarials / Macaca Mulatta / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Mono / Plasmodium berghei / Molecular Structure / Mice / Animals / Rhesus Monkey / Plasmodium falciparum / Antimalarials / Macaca Mulatta / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Mono / Plasmodium berghei / Molecular Structure
An In Vitro Model of Posterior Capsular Opacity: SPARC and TGF- 2 Minimize Epithelial-to-Mesenchymal Transition in Lens Epithelium
Ophthalmology / Immunohistochemistry / Extracellular Matrix / Western blotting / Biological Sciences / DNA / In Vitro / Models / Mice / Animals / Opacity / Cataract / Proteins / Osteonectin / Epithelial cells / Transforming Growth Factor Beta / Biological markers / Cell Proliferation / Lens / Recombinant Proteins / Epithelial to Mesenchymal Transition / Cell Motility / Dna Synthesis / DNA / In Vitro / Models / Mice / Animals / Opacity / Cataract / Proteins / Osteonectin / Epithelial cells / Transforming Growth Factor Beta / Biological markers / Cell Proliferation / Lens / Recombinant Proteins / Epithelial to Mesenchymal Transition / Cell Motility / Dna Synthesis
Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents
Organic Chemistry / Prevention / Cell line / In Vitro / Humans / Endothelial Cells / Drug Design / Endothelial cell / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Endothelial Cells / Drug Design / Endothelial cell / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis
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