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Pyridines
Pyridines
Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist
Virology / Calcium / HIV / Biological Sciences / Humans / Monoclonal Antibodies / Chemotaxis / Human immunodeficiency virus / Pyridines / Monoclonal Antibody / Antiviral Activity / Cell Surface Markers / Heterocyclic compounds / Low molecular weight / Monoclonal Antibodies / Chemotaxis / Human immunodeficiency virus / Pyridines / Monoclonal Antibody / Antiviral Activity / Cell Surface Markers / Heterocyclic compounds / Low molecular weight
MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells
Immune response / Flow Cytometry / Life Sciences / Enzyme Inhibitors / Gene expression / Toll like receptor signaling / Lipopolysaccharide / Humans / NF-kappa B / Intestines / Caco-2 cells / Gram-negative bacteria / Lipopolysaccharides / Epithelial cells / Monocytes / Pyridines / Transfection / Imidazoles / Prostaglandin E2 / Biochemistry and cell biology / Interleukin / Toll like receptor signaling / Lipopolysaccharide / Humans / NF-kappa B / Intestines / Caco-2 cells / Gram-negative bacteria / Lipopolysaccharides / Epithelial cells / Monocytes / Pyridines / Transfection / Imidazoles / Prostaglandin E2 / Biochemistry and cell biology / Interleukin
Incremental conductance levels of GABAA receptors in dopaminergic neurones of the rat substantia nigra pars compacta
Electrophysiology / Immunohistochemistry / Patch-clamp and imaging techniques / Biological Sciences / Dopamine / Animals / Substantia nigra / Neurons / Rats / Pyridines / Wistar Rats / Purkinje Cells / Animals / Substantia nigra / Neurons / Rats / Pyridines / Wistar Rats / Purkinje Cells
Antimalarial Pyrido[1,2- a ]benzimidazoles
Organic Chemistry / Medicinal Chemistry / Malaria / Humans / Mice / Animals / Male / Rats / Plasmodium falciparum / Antimalarials / Pyridines / Benzimidazoles / Structure activity Relationship / Plasmodium berghei / Animals / Male / Rats / Plasmodium falciparum / Antimalarials / Pyridines / Benzimidazoles / Structure activity Relationship / Plasmodium berghei
3-(5-Alkylamino-4-isoxazolyl)-1,2,5,6-tetrahydropyridines: a novel class of central nicotinic receptor ligands
Organic Chemistry / Mass Spectrometry / Magnetic Resonance Spectroscopy / Cerebral Cortex / Animals / Male / Nicotinic Acetylcholine Receptors / Rats / Pyridines / Wistar Rats / Bioorganic and medicinal Chemistry / Muscarinic Receptor / Ligands / Male / Nicotinic Acetylcholine Receptors / Rats / Pyridines / Wistar Rats / Bioorganic and medicinal Chemistry / Muscarinic Receptor / Ligands
Clinical pharmacology of cyclophosphamide
Cancer / Ultrafiltration / Humans / Carbon Isotopes / Prednisolone / Shell Half-Life / Time Factors / Neoplasms / Feces / Pyridines / Body Weight / Alkylation / Liquid Scintillation Counting / Protein Binding / Chronic Kidney Failure / Cyclophosphamide / Allopurinol / Blood Proteins / Shell Half-Life / Time Factors / Neoplasms / Feces / Pyridines / Body Weight / Alkylation / Liquid Scintillation Counting / Protein Binding / Chronic Kidney Failure / Cyclophosphamide / Allopurinol / Blood Proteins
Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists
Organic Chemistry / Animals / Enzyme / Rats / Oximes / Substrate Specificity / Pyridines / Bioorganic and medicinal Chemistry / Carbamates / Substrate Specificity / Pyridines / Bioorganic and medicinal Chemistry / Carbamates
Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1 H-pyrrolo[1,2- c]imidazol-1-ones: A new class of Neuropeptide S antagonists
Inorganic Chemistry / Organic Chemistry / Medicinal Chemistry / Calcium / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure
Farnesyl transferase expression determines clinical response to the docetaxel-lonafarnib combination in patients with advanced malignancies
Cancer / Enzyme Inhibitors / Humans / Female / Male / Middle Aged / Adult / Neoplasms / Pyridines / Pilot Projects / Piperidines / Middle Aged / Adult / Neoplasms / Pyridines / Pilot Projects / Piperidines
The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase
Cancer / Mitosis / Cell line / Humans / Low Dose / Mice / Animals / HIstone Deacetylase / Cell Death / Paclitaxel / Microtubules / Acetylation / Pyridines / Tubulin / Histone deacetylase inhibitors / Histone deacetylases / Piperidines / Synergistic effect / Mice / Animals / HIstone Deacetylase / Cell Death / Paclitaxel / Microtubules / Acetylation / Pyridines / Tubulin / Histone deacetylase inhibitors / Histone deacetylases / Piperidines / Synergistic effect
MAP Kinase Kinase 6 -p38 MAP Kinase Signaling Cascade Regulates Cyclooxygenase-2 Expression in Cardiac Myocytes In Vitro and In Vivo
Enzyme Inhibitors / Gene expression / Transgenic Mice / Protein synthesis / Animals / Phosphorylation / Clinical Sciences / mRna expression levels / Rats / Isoenzymes / Pyridines / Circulation / Tubulin / Imidazoles / Recombinant Protein / MAP Kinase / Heart Ventricles / Prostaglandin E2 / Interleukin / Phosphorylation / Clinical Sciences / mRna expression levels / Rats / Isoenzymes / Pyridines / Circulation / Tubulin / Imidazoles / Recombinant Protein / MAP Kinase / Heart Ventricles / Prostaglandin E2 / Interleukin
MAP Kinase Kinase 6-p38 MAP Kinase Signaling Cascade Regulates Cyclooxygenase-2 Expression in Cardiac Myocytes In Vitro and In Vivo
Enzyme Inhibitors / Gene expression / Transgenic Mice / Protein synthesis / Animals / Phosphorylation / Clinical Sciences / mRna expression levels / Rats / Isoenzymes / Pyridines / Circulation / Tubulin / Imidazoles / Recombinant Protein / MAP Kinase / Heart Ventricles / Prostaglandin E2 / Interleukin / Phosphorylation / Clinical Sciences / mRna expression levels / Rats / Isoenzymes / Pyridines / Circulation / Tubulin / Imidazoles / Recombinant Protein / MAP Kinase / Heart Ventricles / Prostaglandin E2 / Interleukin
5-HT2A and D2 receptor blockade increases cortical DA release via 5-HT1A receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release
Neurochemistry / Dopamine / Vitamin D receptor / Cerebral Cortex / Animals / Male / Benzodiazepines / High Pressure Liquid Chromatography / Microdialysis / Serotonin Receptors / Rats / RISPERIDONE / Pyridines / Atypical Antipsychotics / Amphetamines / Neurosciences / Serotonin Uptake Inhibitors / Male / Benzodiazepines / High Pressure Liquid Chromatography / Microdialysis / Serotonin Receptors / Rats / RISPERIDONE / Pyridines / Atypical Antipsychotics / Amphetamines / Neurosciences / Serotonin Uptake Inhibitors
Trypanocidal Furamidine Analogues: Influence of Pyridine Nitrogens on Trypanocidal Activity, Transport Kinetics, and Resistance Patterns
Microbiology / Medical Microbiology / Female / Animals / Drug Resistance / Nitrogen / Rats / Pyridines / Antimicrobial agents / Trypanocidal Agents / Adenine / Pentamidine / Nitrogen / Rats / Pyridines / Antimicrobial agents / Trypanocidal Agents / Adenine / Pentamidine
An Experimental Look into Subelectron Charge Flow
Quantum Theory / Nickel / CHEMICAL SCIENCES / Electrons / Pyridines / Organometallic Compounds / The American / Organometallic Compounds / The American
The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase
Cancer / Mitosis / Cell line / Humans / Low Dose / Mice / Animals / HIstone Deacetylase / Cell Death / Paclitaxel / Microtubules / Acetylation / Pyridines / Tubulin / Histone deacetylase inhibitors / Histone deacetylases / Piperidines / Synergistic effect / Mice / Animals / HIstone Deacetylase / Cell Death / Paclitaxel / Microtubules / Acetylation / Pyridines / Tubulin / Histone deacetylase inhibitors / Histone deacetylases / Piperidines / Synergistic effect
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