Phosphodiesterase Inhibitors

Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics

Electrophysiology / Calcium / Enzyme Inhibitors / Fluorescent Dyes and Reagents / Confocal Microscopy / cyclic AMP / Animals / Calcium Signaling / Potassium / The / Phosphodiesterase Inhibitors / Epithelial cells / Time Factors / Cilia / Ambystoma / Second Messengers / Gtp Binding Proteins / cyclic GMP / aniline Compounds / Cell Membrane / cyclic AMP / Animals / Calcium Signaling / Potassium / The / Phosphodiesterase Inhibitors / Epithelial cells / Time Factors / Cilia / Ambystoma / Second Messengers / Gtp Binding Proteins / cyclic GMP / aniline Compounds / Cell Membrane

High-level beta-globin expression after retroviral transfer of locus activation region-containing human beta-globin gene derivatives into murine erythroleukemia cells

Gene Therapy / Gene expression / Multidisciplinary / Transgenic Mice / Phosphorus / Cell line / Humans / Mice / Beta decay / Animals / Enzyme / Genes / Phosphodiesterase Inhibitors / Immune system / Transfection / Organic Compound / Gene Transfer / Nucleic Acid / Gene Expression Regulation / DNA sequence / Cell line / Humans / Mice / Beta decay / Animals / Enzyme / Genes / Phosphodiesterase Inhibitors / Immune system / Transfection / Organic Compound / Gene Transfer / Nucleic Acid / Gene Expression Regulation / DNA sequence

Human cone-specific cGMP phosphodiesterase α′ subunit: Complete cDNA sequence and gene arrangement

Phosphodiesterase Inhibitors / Genomic Library / Amino Acid Profile / Molecular Mass / Amino Acid Sequence / cDNA library / Biochemistry and cell biology / cDNA library / Biochemistry and cell biology

Visual field loss after tadalafil: a case report

Case Report / Humans / Male / Clinical Sciences / Phosphodiesterase Inhibitors / Middle Aged / Optometry and Ophthalmology / Scotoma / Visual Fields / Visual Field / Neurosciences / Middle Aged / Optometry and Ophthalmology / Scotoma / Visual Fields / Visual Field / Neurosciences

Biophysical Characterization of Cyclic Nucleotide Phosphodiesterases

Protein Folding / Fluorescence / Arabidopsis thaliana / Saccharomyces cerevisiae / Circular Dichroism / Escherichia coli / Urea / Biochemical / Arabidopsis / Phosphodiesterase Inhibitors / Cyclic nucleotides / Isothermal Titration Calorimetry / Calorimetry / Enzymatic Activity / X Ray Crystallography / Protein Denaturation / Biochemistry and cell biology / Molecular Sequence Data / Escherichia coli / Urea / Biochemical / Arabidopsis / Phosphodiesterase Inhibitors / Cyclic nucleotides / Isothermal Titration Calorimetry / Calorimetry / Enzymatic Activity / X Ray Crystallography / Protein Denaturation / Biochemistry and cell biology / Molecular Sequence Data

Biophysical Characterization of Cyclic Nucleotide Phosphodiesterases

Protein Folding / Fluorescence / Arabidopsis thaliana / Saccharomyces cerevisiae / Circular Dichroism / Escherichia coli / Urea / Biochemical / Arabidopsis / Phosphodiesterase Inhibitors / Cyclic nucleotides / Isothermal Titration Calorimetry / Calorimetry / Enzymatic Activity / X Ray Crystallography / Protein Denaturation / Biochemistry and cell biology / Molecular Sequence Data / Escherichia coli / Urea / Biochemical / Arabidopsis / Phosphodiesterase Inhibitors / Cyclic nucleotides / Isothermal Titration Calorimetry / Calorimetry / Enzymatic Activity / X Ray Crystallography / Protein Denaturation / Biochemistry and cell biology / Molecular Sequence Data

Patient\'s preference of phosphodiesterase 5 inhibitor: side effects vs. efficacy?

Fertility and Sterility / Clinical Sciences / Phosphodiesterase Inhibitors / Public health systems and services research / Side Effect

Patient\'s preference of phosphodiesterase 5 inhibitor: side effects vs. efficacy?

Fertility and Sterility / Clinical Sciences / Phosphodiesterase Inhibitors / Public health systems and services research / Side Effect

Protein kinase A cascade regulates quantal release dispersion at frog muscle endplate

Physiology / Skeletal muscle biology / Enzyme Inhibitors / Biological Sciences / Animals / Reaction Time / Norepinephrine / Phosphodiesterase Inhibitors / Pressure / SYNAPSES / Electric Conductivity / Adenosine Diphosphate / Reaction Time / Norepinephrine / Phosphodiesterase Inhibitors / Pressure / SYNAPSES / Electric Conductivity / Adenosine Diphosphate

Phosphodiesterase 5 inhibition protects against increased intra-abdominal pressure-induced renal dysfunction in experimental congestive heart failure

Heart Failure / Kidney / Hemodynamics / Animals / Male / Phosphodiesterase Inhibitors / Rats / Glomerular Filtration Rate / Phosphodiesterase Inhibitors / Rats / Glomerular Filtration Rate

Synergy between Natriuretic Peptides and Phosphodiesterase 5 Inhibitors Ameliorates Pulmonary Arterial Hypertension

Treatment Outcome / Pulmonary Hypertension / Blood Pressure / Nitric oxide / Animals / Male / Disease Severity / American / Animal Model / Phosphodiesterase Inhibitors / Rats / Protease Inhibitors / Combination drug therapy / Ct Image of Pulmonary Artery / Vascular Reactivity / Vasodilation / cyclic GMP / Cyclic / Vascular Resistance / Atrial Natriuretic Factor / Pulmonary Artery / Male / Disease Severity / American / Animal Model / Phosphodiesterase Inhibitors / Rats / Protease Inhibitors / Combination drug therapy / Ct Image of Pulmonary Artery / Vascular Reactivity / Vasodilation / cyclic GMP / Cyclic / Vascular Resistance / Atrial Natriuretic Factor / Pulmonary Artery

Synergy between Natriuretic Peptides and Phosphodiesterase 5 Inhibitors Ameliorates Pulmonary Arterial Hypertension

Treatment Outcome / Pulmonary Hypertension / Blood Pressure / Nitric oxide / Animals / Male / Disease Severity / American / Animal Model / Phosphodiesterase Inhibitors / Rats / Protease Inhibitors / Combination drug therapy / Ct Image of Pulmonary Artery / Vascular Reactivity / Vasodilation / cyclic GMP / Cyclic / Vascular Resistance / Atrial Natriuretic Factor / Pulmonary Artery / Male / Disease Severity / American / Animal Model / Phosphodiesterase Inhibitors / Rats / Protease Inhibitors / Combination drug therapy / Ct Image of Pulmonary Artery / Vascular Reactivity / Vasodilation / cyclic GMP / Cyclic / Vascular Resistance / Atrial Natriuretic Factor / Pulmonary Artery

Compartmentalized Phosphodiesterase-2 Activity Blunts -Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway

Calcium / Signal Transduction / Mice / cyclic AMP / Nitric oxide / Animals / Feedback Control / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Circulation / Adenine / cyclic GMP / Adenylyl Cyclase / Isoproterenol / Animals / Feedback Control / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Circulation / Adenine / cyclic GMP / Adenylyl Cyclase / Isoproterenol

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