Phosphodiesterase Inhibitors - Page 3

Synergy between Natriuretic Peptides and Phosphodiesterase 5 Inhibitors Ameliorates Pulmonary Arterial Hypertension

Treatment Outcome / Pulmonary Hypertension / Blood Pressure / Nitric oxide / Animals / Male / Disease Severity / American / Animal Model / Phosphodiesterase Inhibitors / Rats / Protease Inhibitors / Combination drug therapy / Ct Image of Pulmonary Artery / Vascular Reactivity / Vasodilation / cyclic GMP / Vascular Resistance / Atrial Natriuretic Factor / Male / Disease Severity / American / Animal Model / Phosphodiesterase Inhibitors / Rats / Protease Inhibitors / Combination drug therapy / Ct Image of Pulmonary Artery / Vascular Reactivity / Vasodilation / cyclic GMP / Vascular Resistance / Atrial Natriuretic Factor

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PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support

Treatment Outcome / Pulmonary Hypertension / Humans / Hemodynamics / Female / Male / Left Ventricular Dysfunction / Phosphodiesterase Inhibitors / Middle Aged / Adult / Mechanical Circulatory Support / Continuous Flow Heart Assist Devices / Vascular Resistance / Male / Left Ventricular Dysfunction / Phosphodiesterase Inhibitors / Middle Aged / Adult / Mechanical Circulatory Support / Continuous Flow Heart Assist Devices / Vascular Resistance

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Soy polysaccharide as a novel superdisintegrant in sildenafil citrate sublingual tablets: preparation, characterization, and in vivo evaluation

Pharmaceutical Technology / Polysaccharides / Pharmaceutical Chemistry / Humans / Wettability / Male / Hardness / Solubility / Phosphodiesterase Inhibitors / Soybeans / Adult / Tablets / Excipients / Drug Stability / Biological Availability / Male / Hardness / Solubility / Phosphodiesterase Inhibitors / Soybeans / Adult / Tablets / Excipients / Drug Stability / Biological Availability

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Intracellular Compartmentalization of PDE4 Cyclic AMP-Specific Phosphodiesterases

Membrane Proteins / Confocal Microscopy / Gene expression / Methods / cyclic AMP / Animals / Alternative splicing / Plasmids / Clinical Sciences / Phosphodiesterase Inhibitors / Fluorescent Antibody Technique / Isoenzymes / Transfection / Alternative Splicing / Protein Biosynthesis / Animals / Alternative splicing / Plasmids / Clinical Sciences / Phosphodiesterase Inhibitors / Fluorescent Antibody Technique / Isoenzymes / Transfection / Alternative Splicing / Protein Biosynthesis

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PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support

Treatment Outcome / Pulmonary Hypertension / Humans / Hemodynamics / Female / Male / Left Ventricular Dysfunction / Phosphodiesterase Inhibitors / Middle Aged / Adult / Mechanical Circulatory Support / Continuous Flow Heart Assist Devices / Vascular Resistance / Male / Left Ventricular Dysfunction / Phosphodiesterase Inhibitors / Middle Aged / Adult / Mechanical Circulatory Support / Continuous Flow Heart Assist Devices / Vascular Resistance

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Disfunción de la [Ca2+] diastólica en cardiomiocitos aislados de pacientes chagásicos

Calcium / Cell separation / Biopsy / Latin America / Humans / Female / Male / Microelectrodes / Chagas disease / Phosphodiesterase Inhibitors / Middle Aged / Trypanosoma Cruzi / Adult / Chagas Cardiomyopathy / Phenylephrine / Boron Compounds / Intracellular Calcium / Female / Male / Microelectrodes / Chagas disease / Phosphodiesterase Inhibitors / Middle Aged / Trypanosoma Cruzi / Adult / Chagas Cardiomyopathy / Phenylephrine / Boron Compounds / Intracellular Calcium

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Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo

Kinetics / Multidisciplinary / Cell line / Humans / G protein-coupled receptors / Luminescence / Phosphodiesterase Inhibitors / Protein Complex Detection / Cell Survival / Protein Kinase Inhibitors / Biosensing Techniques / Luminescence / Phosphodiesterase Inhibitors / Protein Complex Detection / Cell Survival / Protein Kinase Inhibitors / Biosensing Techniques

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Biophysical Characterization of Cyclic Nucleotide Phosphodiesterases

Protein Folding / Fluorescence / Arabidopsis thaliana / Saccharomyces cerevisiae / Circular Dichroism / Escherichia coli / Urea / Biochemical / Arabidopsis / Phosphodiesterase Inhibitors / Cyclic nucleotides / Isothermal Titration Calorimetry / Calorimetry / Enzymatic Activity / X Ray Crystallography / Protein Denaturation / Biochemistry and cell biology / Escherichia coli / Urea / Biochemical / Arabidopsis / Phosphodiesterase Inhibitors / Cyclic nucleotides / Isothermal Titration Calorimetry / Calorimetry / Enzymatic Activity / X Ray Crystallography / Protein Denaturation / Biochemistry and cell biology

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Compartmentalized Phosphodiesterase-2 Activity Blunts -Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway

Calcium / Signal Transduction / Mice / cyclic AMP / Nitric oxide / Animals / Feedback Control / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Circulation / Adenine / cyclic GMP / Adenylyl Cyclase / Isoproterenol / Animals / Feedback Control / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Circulation / Adenine / cyclic GMP / Adenylyl Cyclase / Isoproterenol

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Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages

Immunology / Phosphodiesterase Inhibitors / Public health systems and services research / Cyclic nucleotides / Alveolar Macrophage

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Oral Sildenafil Reduces Pulmonary Hypertension After Cardiac Surgery

Pulmonary Hypertension / Cardiac Surgery / Humans / Hemodynamics / Nitric oxide / Female / Drug Resistance / Male / Clinical Sciences / Phosphodiesterase Inhibitors / Aged / Middle Aged / Adult / Retrospective Studies / Drug evaluation / Nitroglycerin / Vascular Resistance / Female / Drug Resistance / Male / Clinical Sciences / Phosphodiesterase Inhibitors / Aged / Middle Aged / Adult / Retrospective Studies / Drug evaluation / Nitroglycerin / Vascular Resistance

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Phosphodiesterase 5 inhibitors lower both portal and pulmonary pressure in portopulmonary hypertension: a case report

Case Report / Portal hypertension / Liver Cirrhosis / Phosphodiesterase Inhibitors / Cardiac Output Monitoring / Pulse Rate / Pressure Gradient / Medical Case Reports / Pulse Rate / Pressure Gradient / Medical Case Reports

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Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo

Kinetics / Multidisciplinary / Cell line / Humans / G protein-coupled receptors / Luminescence / Phosphodiesterase Inhibitors / Protein Complex Detection / Cell Survival / Protein Kinase Inhibitors / Biosensing Techniques / Luminescence / Phosphodiesterase Inhibitors / Protein Complex Detection / Cell Survival / Protein Kinase Inhibitors / Biosensing Techniques

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an experimental lung transplantation model. Long-acting oral phosphodiesterase inhibition preconditions against reperfusion injury in

Phosphodiesterase Inhibitors / Reperfusion injury / Heart and Lung Transplantation

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An extracellular endodeoxyribonuclease from Streptomyces aureofaciens

Biological Sciences / Physical sciences / Temperature / Nitrogen / Zinc / Phosphodiesterase Inhibitors / Substrate Specificity / Amino Acid Profile / Molecular weight / Hydrogen-Ion Concentration / Ammonium Sulfate / Biochemistry and cell biology / single stranded DNA / Phosphodiesterase Inhibitors / Substrate Specificity / Amino Acid Profile / Molecular weight / Hydrogen-Ion Concentration / Ammonium Sulfate / Biochemistry and cell biology / single stranded DNA

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Mammalian 2\',3\' cyclic nucleotide phosphodiesterase (CNP) can function as a tRNA splicing enzyme in vivo

RNA / Saccharomyces cerevisiae / Mutation / Animals / Enzyme / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Biochemistry and cell biology / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Biochemistry and cell biology

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