Phosphodiesterase Inhibitors

Disfunción de la [Ca2+] diastólica en cardiomiocitos aislados de pacientes chagásicos

Calcium / Cell separation / Biopsy / Latin America / Humans / Female / Male / Microelectrodes / Chagas disease / Phosphodiesterase Inhibitors / Middle Aged / Trypanosoma Cruzi / Adult / Chagas Cardiomyopathy / Phenylephrine / Boron Compounds / Intracellular Calcium / Female / Male / Microelectrodes / Chagas disease / Phosphodiesterase Inhibitors / Middle Aged / Trypanosoma Cruzi / Adult / Chagas Cardiomyopathy / Phenylephrine / Boron Compounds / Intracellular Calcium

Differential Amplification of Intron-containing Transcripts Reveals Long Term Potentiation-associated Up-regulation of Specific Pde10A Phosphodiesterase Splice Variants

Long Term Potentiation / Biological Chemistry / Biological Sciences / Humans / Mice / Animals / Male / Biological / Neuronal Plasticity / CHEMICAL SCIENCES / Phosphodiesterase Inhibitors / Introns / Rats / Isoenzymes / Animals / Male / Biological / Neuronal Plasticity / CHEMICAL SCIENCES / Phosphodiesterase Inhibitors / Introns / Rats / Isoenzymes

A temporal-specific and transient cAMP increase characterizes odorant classical conditioning

Learning & Memory / Learning / Biological Sciences / Classical Conditioning / cyclic AMP / Female / Animals / Male / Phosphodiesterase Inhibitors / Odors / Rats / Time Factors / Olfactory Bulb / Isoproterenol / Female / Animals / Male / Phosphodiesterase Inhibitors / Odors / Rats / Time Factors / Olfactory Bulb / Isoproterenol

Bioactive triterpenoids fromVochysia pacifica interact with cyclic nucleotide phosphodiesterase isozyme PDE4

Biological Sciences / Phytotherapy / Humans / Myrtaceae / CHEMICAL SCIENCES / Phosphodiesterase Inhibitors / Plant extracts / Isoenzymes / Triterpenes / Phosphodiesterase Inhibitors / Plant extracts / Isoenzymes / Triterpenes

Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase

Enzyme Inhibitors / Nitric oxide / Animals / Retina / Phosphodiesterase Inhibitors / Rats / Penicillamine / Protein Kinase / Guanylate Cyclase / cyclic GMP / Rats / Penicillamine / Protein Kinase / Guanylate Cyclase / cyclic GMP

The phosphodiesterase-5 inhibitor vardenafil improves cardiovascular dysfunction in experimental diabetes mellitus

British / Diabetes mellitus / Hemodynamics / Animals / Heart / Vascular endothelium / Left Ventricular Dysfunction / Phosphodiesterase Inhibitors / Rats / Myocardium / Transforming Growth Factor Beta / Imidazoles / Triazines / Vasodilation / cyclic GMP / Isometric Contraction / Vascular endothelium / Left Ventricular Dysfunction / Phosphodiesterase Inhibitors / Rats / Myocardium / Transforming Growth Factor Beta / Imidazoles / Triazines / Vasodilation / cyclic GMP / Isometric Contraction

Compartmentalized Phosphodiesterase-2 Activity Blunts -Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway

Calcium / Signal Transduction / Mice / cyclic AMP / Nitric oxide / Animals / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Circulation / Adenine / cyclic GMP / Isoproterenol / Animals / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Circulation / Adenine / cyclic GMP / Isoproterenol

Compartmentalized Phosphodiesterase-2 Activity Blunts -Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway

Calcium / Signal Transduction / Mice / cyclic AMP / Nitric oxide / Animals / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Circulation / Adenine / cyclic GMP / Isoproterenol / Animals / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Circulation / Adenine / cyclic GMP / Isoproterenol

Tratamiento médico en pacientes con hipertensión pulmonar tromboembólica crónica

Clinical Trial / Pulmonary Hypertension / Humans / Chronic Disease / Thromboembolism / Clinical Sciences / Phosphodiesterase Inhibitors / Vascular Remodeling / Peripheral Vascular Disease / Medical Treatment / Clinical Sciences / Phosphodiesterase Inhibitors / Vascular Remodeling / Peripheral Vascular Disease / Medical Treatment

Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity

Neuroscience / Psychology / Animal Behavior / Memory / Startle Reflex / Prepulse Inhibition / Mice / Animals / Male / dopamine receptor D4 / Haloperidol / Phosphodiesterase Inhibitors / Side Effect / Second Messengers / Effective Dose / Neurosciences / Dextroamphetamine / Prepulse Inhibition / Mice / Animals / Male / dopamine receptor D4 / Haloperidol / Phosphodiesterase Inhibitors / Side Effect / Second Messengers / Effective Dose / Neurosciences / Dextroamphetamine

Sildenafil Preserves Intracorporeal Smooth Muscle After Radical Retropubic Prostatectomy

Urology / Erectile dysfunction / Humans / Smooth muscle / Male / Penis / Clinical Sciences / Phosphodiesterase Inhibitors / Middle Aged / Pilot Projects / Penis / Clinical Sciences / Phosphodiesterase Inhibitors / Middle Aged / Pilot Projects

Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility

Enzyme Inhibitors / Humans / Meiosis / Mice / cyclic AMP / Female / Ovulation / Animals / Clinical / Phosphodiesterase Inhibitors / Isoenzymes / Cyclic nucleotides / Ovary / Oocytes / Female Infertility / Clinical Investigation / Female / Ovulation / Animals / Clinical / Phosphodiesterase Inhibitors / Isoenzymes / Cyclic nucleotides / Ovary / Oocytes / Female Infertility / Clinical Investigation

D020 The polyphenol curcumin inhibits in vitro angiogenesis and cyclic nucleotide phosphodiesterases (PDEs) activities similarly to PDE inhibitors

Clinical Sciences / Phosphodiesterase Inhibitors / Cyclic nucleotides

PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support

Treatment Outcome / Pulmonary Hypertension / Humans / Hemodynamics / Female / Male / Left Ventricular Dysfunction / Phosphodiesterase Inhibitors / Middle Aged / Adult / Mechanical Circulatory Support / Continuous Flow Heart Assist Devices / Vascular Resistance / Male / Left Ventricular Dysfunction / Phosphodiesterase Inhibitors / Middle Aged / Adult / Mechanical Circulatory Support / Continuous Flow Heart Assist Devices / Vascular Resistance

Androgens Regulate Phosphodiesterase Type 5 Expression and Functional Activity in Corpora Cavernosa

Endocrinology / Immunohistochemistry / Gene expression / Real-time RT-PCR / Western blotting / Biological Sciences / Humans / Testosterone / Female / Animals / Male / Androgens / Prostate / Penis / tESTIS / Enzyme / Phosphodiesterase Inhibitors / Late onset hypogonadism / Western blot / Protein Expression / Rabbits / Epididymis / Female To Male / Level / cyclic GMP / Biological Sciences / Humans / Testosterone / Female / Animals / Male / Androgens / Prostate / Penis / tESTIS / Enzyme / Phosphodiesterase Inhibitors / Late onset hypogonadism / Western blot / Protein Expression / Rabbits / Epididymis / Female To Male / Level / cyclic GMP

Cilostazol, a Type III Phosphodiesterase Inhibitor, Reduces Ischemia/Reperfusion-Induced Spinal Cord Injury

Treatment Outcome / Animals / Male / Phosphodiesterase Inhibitors / Rats / Wistar Rats / Reperfusion injury / Spinal Cord Injuries / Wistar Rats / Reperfusion injury / Spinal Cord Injuries

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