Pharmacokinetics

Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor

Metabolism / Evaluation / Pharmacokinetics / Drug metabolism / Mitochondria / Dogs / Cell line / Transport / Humans / Permeability / Mice / Pharmaceutical Sciences / Female / Animals / Male / Electron Transport / Bioavailability / Clearance / Rats / Hepatocytes / Antimalarials / Biotransformation / Macaca fascicularis / Protein Binding / Dogs / Cell line / Transport / Humans / Permeability / Mice / Pharmaceutical Sciences / Female / Animals / Male / Electron Transport / Bioavailability / Clearance / Rats / Hepatocytes / Antimalarials / Biotransformation / Macaca fascicularis / Protein Binding

Intoxicación por ingesta de levotiroxina (Eutirox®)

Pharmacokinetics / Hemodialysis

Intoxicación por ingesta de levotiroxina (Eutirox ®)

Pharmacokinetics / Hemodialysis

In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity

Organic Chemistry / Medicinal Chemistry / Obesity / Pharmacokinetics / Pharmaceutical Chemistry / Dogs / Cell line / In Vitro / Humans / Models / Animals / Drug Design / Enzyme / Food intake / In Vivo / Rats / Rat / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Chemical Synthesis / Carbamates / Selectivity / Dogs / Cell line / In Vitro / Humans / Models / Animals / Drug Design / Enzyme / Food intake / In Vivo / Rats / Rat / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Chemical Synthesis / Carbamates / Selectivity

Características farmacológicas de los ARA-II. ¿Son todos iguales?

Pharmacokinetics / Heart Failure / Diabetes mellitus

Características farmacológicas de los ARA-II. ¿Son todos iguales?

Pharmacokinetics / Heart Failure / Diabetes mellitus

Uso actual de los antifúngicos triazoles en niños

Pediatrics / Pharmacokinetics / Pharmacodynamics

Características farmacológicas de los ARA-II. ¿Son todos iguales?

Pharmacokinetics / Heart Failure / Diabetes mellitus

Características farmacológicas de los ARA-II. ¿Son todos iguales?

Pharmacokinetics / Heart Failure / Diabetes mellitus

Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification

Organic Chemistry / Pharmacokinetics / In Vitro / Humans / Animals / Drug Design / Acetylcholine / Bioavailability / Microdialysis / In Vivo / Rats / Rat / Cholinergic Receptor / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Chemical Synthesis / Area Under Curve / Benzamides / Drug Design / Acetylcholine / Bioavailability / Microdialysis / In Vivo / Rats / Rat / Cholinergic Receptor / Bioorganic and medicinal Chemistry / Structure activity Relationship / Muscarinic Receptor / Chemical Synthesis / Area Under Curve / Benzamides

The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria

Nonparametric Statistics / British / Pharmacokinetics / Humans / Female / Male / Confidence intervals / Sesquiterpenes / Adult / Antimalarials / Cross-Over Studies / Area Under Curve / Male / Confidence intervals / Sesquiterpenes / Adult / Antimalarials / Cross-Over Studies / Area Under Curve

The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria

Nonparametric Statistics / British / Pharmacokinetics / Humans / Female / Male / Confidence intervals / Sesquiterpenes / Adult / Antimalarials / Cross-Over Studies / Area Under Curve / Male / Confidence intervals / Sesquiterpenes / Adult / Antimalarials / Cross-Over Studies / Area Under Curve

Activity against Human Immunodeficiency Virus Type 1, Intracellular Metabolism, and Effects on Human DNA Polymerases of 4\'-Ethynyl-2-Fluoro-2\'-Deoxyadenosine

Microbiology / Metabolism / Medical Microbiology / Pharmacokinetics / HIV / Humans / Virus / Multidrug Resistance / Human immunodeficiency virus / Tritium / Antimicrobial agents / Microbial Sensitivity Tests / Biological activity / Culture Media / DNA Polymerase / Intracellular / Humans / Virus / Multidrug Resistance / Human immunodeficiency virus / Tritium / Antimicrobial agents / Microbial Sensitivity Tests / Biological activity / Culture Media / DNA Polymerase / Intracellular

A model of flexible uptake of two essential resources

Mathematics / Static Analysis / Pharmacokinetics / Phytoplankton / Theoretical biology / Biological Sciences / Adaptive Dynamics / Mathematical Sciences / Elements / Animals / Bacteria / Model development / Experimental Tests / Growth rate / Osmosis / Dynamic Model of WSN / Environment / Biological Sciences / Adaptive Dynamics / Mathematical Sciences / Elements / Animals / Bacteria / Model development / Experimental Tests / Growth rate / Osmosis / Dynamic Model of WSN / Environment

Effect of PF-04217329 a prodrug of a selective prostaglandin EP2 agonist on intraocular pressure in preclinical models of glaucoma

Pharmacology / Quantum Physics / Calcium / Pharmacokinetics / Cornea / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma

Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma

Pharmacology / Quantum Physics / Calcium / Pharmacokinetics / Cornea / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma

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