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Pharmacokinetics

PET kinetic analysis—compartmental model

Kinetics / Magnetic Resonance Imaging / Pharmacokinetics / Experimental Design / Positron Emission Tomography / PET / Humans / Computer Simulation / Clinical Sciences / Theoretical Models / Single Photon Emission Computed Tomography / Radioisotopes / Telencephalon / PET / Humans / Computer Simulation / Clinical Sciences / Theoretical Models / Single Photon Emission Computed Tomography / Radioisotopes / Telencephalon

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Utilidad clínica de la micafungina en el tratamiento de las candidiasis invasoras en el neonato

Pharmacokinetics / Adolescent / Critical Care / Safety / Prospective studies / Humans / Child / Female / Male / Candidiasis / Efficacy / Infant / Incidence / Newborn Infant / Neutrophils / Adult / Immunocompromised host / Retrospective Studies / Age Factors / Antifungal Agents / Combination drug therapy / Neonatal Intensive Care Unit / Critical Illness / Mortality rate / Lipopeptides / Hematopoietic Stem Cell Transplantation / Humans / Child / Female / Male / Candidiasis / Efficacy / Infant / Incidence / Newborn Infant / Neutrophils / Adult / Immunocompromised host / Retrospective Studies / Age Factors / Antifungal Agents / Combination drug therapy / Neonatal Intensive Care Unit / Critical Illness / Mortality rate / Lipopeptides / Hematopoietic Stem Cell Transplantation

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Application of the Suzuki–Miyaura cross-coupling to increase antimicrobial potency generates promising novel antibacterials

Organic Chemistry / Clinical Trial / Pharmacokinetics / Patch-clamp and imaging techniques / Humans / Mice / Animals / Calcium Signaling / Antimicrobial Peptide / Gram Positive Bacteria / Anti-Bacterial Agents / Bioorganic and medicinal Chemistry / Protein Binding / DNA binding proteins / Mice / Animals / Calcium Signaling / Antimicrobial Peptide / Gram Positive Bacteria / Anti-Bacterial Agents / Bioorganic and medicinal Chemistry / Protein Binding / DNA binding proteins

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A toxicokinetic comparison of two species of low larkspur (Delphinium spp.) in cattle

Pharmacokinetics / Animal Production / Veterinary Science / Animals / Male / Alkaloids / Cattle / Veterinary Sciences / Species Specificity / Delphinium / Alkaloids / Cattle / Veterinary Sciences / Species Specificity / Delphinium

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2-Arylpyrimidines: Novel CRF-1 receptor antagonists

Organic Chemistry / Depression / Kinetics / Pharmacokinetics / Pharmaceutical Chemistry / In Vitro / Humans / Animals / Drug Design / Solubility / In Vivo / Rats / Rat / Ether / Molecular Conformation / Bioorganic and medicinal Chemistry / Affinity / Structure activity Relationship / Chemical Synthesis / Molecular Structure / In Vitro / Humans / Animals / Drug Design / Solubility / In Vivo / Rats / Rat / Ether / Molecular Conformation / Bioorganic and medicinal Chemistry / Affinity / Structure activity Relationship / Chemical Synthesis / Molecular Structure

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Mycophenolic acid clinical pharmacokinetics influenced by a cyclosporine C2 based immunosuppressive regimen in renal allograft recipients

Pharmacology / Nephrology / Surgery / Urology / Treatment / Kidney transplantation / Pharmacokinetics / Drug interactions / Medicine / Concentration / Humans / Female / Male / Cyclosporine / Clinical Sciences / Aged / Middle Aged / Adult / Transplant / Urinary System / Combination drug therapy / Kidney transplantation / Pharmacokinetics / Drug interactions / Medicine / Concentration / Humans / Female / Male / Cyclosporine / Clinical Sciences / Aged / Middle Aged / Adult / Transplant / Urinary System / Combination drug therapy

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A semiparametric deconvolution model to establish in vivo-in vitro correlation applied to OROS oxybutynin

Modeling / Prediction / Pharmacokinetics / Pharmaceutical Chemistry / Dosage Form / In Vitro / Humans / Controlled release / Pharmaceutical Sciences / Estimation / Bioavailability / Mathematical Model / In Vivo / Linear Systems / Reproducibility of Results / Active Ingredient / Biological Availability / Enantiomer / In Vitro / Humans / Controlled release / Pharmaceutical Sciences / Estimation / Bioavailability / Mathematical Model / In Vivo / Linear Systems / Reproducibility of Results / Active Ingredient / Biological Availability / Enantiomer

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Non-compartment model to compartment model pharmacokinetics transformation meta-analysis – a multivariate nonlinear mixed model

Nonlinear dynamics / Drug Discovery / Pharmacokinetics / Drug development / Parameter estimation / Multivariate Analysis / Statistical Inference / First-Order Logic / Meta Analysis / Simulation Study / Reproducibility of Results / Statistical Estimation / Multivariate Analysis / Statistical Inference / First-Order Logic / Meta Analysis / Simulation Study / Reproducibility of Results / Statistical Estimation

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Comparison of plasma and tissue disposition of enrofloxacin in rainbow trout ( Oncorhynchus mykiss ) and common carp ( Cyprinus carpio ) after a single oral administration

Pharmacokinetics / Liver / Animals / Muscles / Anti-Bacterial Agents / Biotransformation / Food Sciences / Carps / Ciprofloxacin / Species Specificity / Oncorhynchus Mykiss / Fluoroquinolones / Biotransformation / Food Sciences / Carps / Ciprofloxacin / Species Specificity / Oncorhynchus Mykiss / Fluoroquinolones

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Comparing hypoxia-targeting potential of 99m Tc(CO) 3 -labeled 2-nitro and 4-nitroimidazole

Organic Chemistry / Cancer / Hypoxia / Pharmacokinetics / DISTRIBUTION / Distribution / Chemical Synthesis / Distribution / Chemical Synthesis

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Effect of PF-04217329 a prodrug of a selective prostaglandin EP2 agonist on intraocular pressure in preclinical models of glaucoma

Pharmacology / Quantum Physics / Calcium / Pharmacokinetics / Cornea / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma / Dogs / Prodrugs / Humans / cyclic AMP / Glaucoma / Animals / Male / Intraocular Pressure / Optometry and Ophthalmology / Topical Drug Administration / Clinical Study / Macaca fascicularis / Iris / Rabbits / Visual Field / Biological Availability / Ophthalmic Solutions / Neurosciences / Prostaglandin E2 / Primary Open Angle Glaucoma

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Microneedles: A Valuable Physical Enhancer to Increase Transdermal Drug Delivery

Immune response / Pharmacokinetics / Drug delivery / Clinical Pharmacology / Humans / Permeability / Animals / Drug Delivery Systems / The / Skin / Vaccination / Transdermal Drug Delivery System / Microtechnology / DNA vaccine / Human Subjects / Equipment Design / Stratum Corneum / Transdermal Drug Delivery / Needles / Pharmaceutical preparations / Permeability / Animals / Drug Delivery Systems / The / Skin / Vaccination / Transdermal Drug Delivery System / Microtechnology / DNA vaccine / Human Subjects / Equipment Design / Stratum Corneum / Transdermal Drug Delivery / Needles / Pharmaceutical preparations

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Comparing hypoxia-targeting potential of 99m Tc(CO) 3 -labeled 2-nitro and 4-nitroimidazole

Organic Chemistry / Cancer / Hypoxia / Pharmacokinetics / DISTRIBUTION / Distribution / Chemical Synthesis / Distribution / Chemical Synthesis

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Discovery of 5-[[4-[(2,3-Dimethyl-2 H -indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor †

Organic Chemistry / Medicinal Chemistry / Pharmacokinetics / Macromolecular X-Ray Crystallography / Cell line / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor / In Vitro / Humans / Cancer Therapy / Mice / Animals / VEGFR / In Vivo / Endothelial cell / Isoenzymes / Medicinal / Neoplasms / Biological activity / Isozyme / Protein Kinase Inhibitors / Molecular Structure / Vascular Endothelial Growth Factor / Growth factor receptor / Vascular endothelial growth factor receptor

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Uso actual de los antifúngicos triazoles en niños

Pediatrics / Pharmacokinetics / Pharmacodynamics

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Uso actual de los antifúngicos triazoles en niños

Pediatrics / Pharmacokinetics / Pharmacodynamics

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