Pharmaceutical Chemistry - Page 3

Cubyl amides: Novel P2X7 receptor antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / Animals / Spinal Cord / Microglia / Drug Design / High Pressure Liquid Chromatography / Rational drug design / Amides / Rats / Molecular Conformation / Bioorganic and medicinal Chemistry / Benzamides / Spinal Cord / Microglia / Drug Design / High Pressure Liquid Chromatography / Rational drug design / Amides / Rats / Molecular Conformation / Bioorganic and medicinal Chemistry / Benzamides

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Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: Effects on physicochemical properties

Scanning Electron Microscopy / Crystallization / Polymers / Pharmaceutical Chemistry / Adsorption / Solubility / European / Hydroxypropyl Methylcellulose / Chemical Precipitation / Particle Size / Spectrum analysis / Surface Active Agents / Water soluble polymers / X Ray Photoelectron Spectroscopy / Excipients / Physicochemical Properties / Sodium Lauryl Sulphate / Solubility / European / Hydroxypropyl Methylcellulose / Chemical Precipitation / Particle Size / Spectrum analysis / Surface Active Agents / Water soluble polymers / X Ray Photoelectron Spectroscopy / Excipients / Physicochemical Properties / Sodium Lauryl Sulphate

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A semiparametric deconvolution model to establish in vivo-in vitro correlation applied to OROS oxybutynin

Modeling / Prediction / Pharmacokinetics / Pharmaceutical Chemistry / Dosage Form / In Vitro / Humans / Controlled release / Pharmaceutical Sciences / Estimation / Bioavailability / Mathematical Model / In Vivo / Linear Systems / Reproducibility of Results / Active Ingredient / Biological Availability / Enantiomer / In Vitro / Humans / Controlled release / Pharmaceutical Sciences / Estimation / Bioavailability / Mathematical Model / In Vivo / Linear Systems / Reproducibility of Results / Active Ingredient / Biological Availability / Enantiomer

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Comparative QSAR modelling of 2-phenylindole-3-carbaldehyde derivatives as potential antimitotic agents

Organic Chemistry / Principal Component Analysis / Pharmaceutical Chemistry / Mitosis / Humans / Drug Design / Regression Analysis / Quantitative Structure Activity Relationship / Microtubules / Surface Area / Molecular Structure / Drug Design / Regression Analysis / Quantitative Structure Activity Relationship / Microtubules / Surface Area / Molecular Structure

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Cubyl amides: Novel P2X7 receptor antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / Animals / Spinal Cord / Microglia / Drug Design / High Pressure Liquid Chromatography / Rational drug design / Amides / Rats / Molecular Conformation / Bioorganic and medicinal Chemistry / Benzamides / Spinal Cord / Microglia / Drug Design / High Pressure Liquid Chromatography / Rational drug design / Amides / Rats / Molecular Conformation / Bioorganic and medicinal Chemistry / Benzamides

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Preliminary pharmaceutical development of antimalarial–antibiotic cotherapy as a pre-referral paediatric treatment of fever in malaria endemic areas

Malaria / Pharmaceutical Technology / Powder Diffraction / Crystallization / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Pharmaceutics / Humans / Animals / Endemic Diseases / Solubility / Anti-Bacterial Agents / Antimalarials / Tablets / Age Factors / Rabbits / Azithromycin / Capsules / Excipients / Biological Availability / Macromolecular X-Ray Crystallography / Pharmaceutics / Humans / Animals / Endemic Diseases / Solubility / Anti-Bacterial Agents / Antimalarials / Tablets / Age Factors / Rabbits / Azithromycin / Capsules / Excipients / Biological Availability

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Cyclic α-Amino Acids via Enantioselective Metal-Catalyzed Cascade Reactions of Dienamides in Supercritical Carbon Dioxide

Analytical Chemistry / Computational Chemistry / Quantum Chemistry / Inorganic Chemistry / Organic Chemistry / Physical Chemistry / Crystallography / Medicinal Chemistry / Polymer Chemistry / Reaction Mechanisms / Green Chemistry / Structure / Biosensors / Supramolecular Chemistry / Electrochemistry / Catalysis / Kinetics / Photochemistry / Spectroscopy / Mass Spectrometry / Self Assembly / Nanotechnology / Biological Chemistry / Pharmaceutical Chemistry / Surface Chemistry / Ionic Liquids / Biocatalysis / Ab initio calculations / Sensors / Scientific / Educational / Density Functional Theory / Combinatorial Chemistry / Colloids / Macromolecules / Interfaces / Proteins / CHEMICAL SCIENCES / Supercritical carbon dioxide / Crystal Structures / BioSensors / Combinatorial / Physical Chemistry / Crystallography / Medicinal Chemistry / Polymer Chemistry / Reaction Mechanisms / Green Chemistry / Structure / Biosensors / Supramolecular Chemistry / Electrochemistry / Catalysis / Kinetics / Photochemistry / Spectroscopy / Mass Spectrometry / Self Assembly / Nanotechnology / Biological Chemistry / Pharmaceutical Chemistry / Surface Chemistry / Ionic Liquids / Biocatalysis / Ab initio calculations / Sensors / Scientific / Educational / Density Functional Theory / Combinatorial Chemistry / Colloids / Macromolecules / Interfaces / Proteins / CHEMICAL SCIENCES / Supercritical carbon dioxide / Crystal Structures / BioSensors / Combinatorial

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Subsequent entry biologics/biosimilars: a viewpoint from Canada

Rheumatology / Patient Safety / Treatment Outcome / Rheumatoid Arthritis / Pharmaceutical Chemistry / DNA / Canada / Humans / Monoclonal Antibodies / Clinical Sciences / Drug Costs / Genetic Recombination / Drug Industry / DNA / Canada / Humans / Monoclonal Antibodies / Clinical Sciences / Drug Costs / Genetic Recombination / Drug Industry

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New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / DBA / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing

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New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / DBA / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing / Animals / Drug Design / Benzodiazepines / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Functional Testing

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In vitro cytotoxicity, in vivo biodistribution and antitumor activity of HPMA copolymer–5-fluorouracil conjugates

Pharmaceutical Chemistry / Cell line / Humans / Mice / Female / Animals / European / Spectrum / Time Factors / HeLa cells / Antitumor Activity / Drug Carriers / Drug Compounding / Drug Stability / Biological Availability / Cell Survival / Tumor Growth / Clinical Application / Control Group / Animals / European / Spectrum / Time Factors / HeLa cells / Antitumor Activity / Drug Carriers / Drug Compounding / Drug Stability / Biological Availability / Cell Survival / Tumor Growth / Clinical Application / Control Group

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Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist

Organic Chemistry / Pharmaceutical Chemistry / Mice / Animals / Drug Design / Molecular Conformation / Bioorganic and medicinal Chemistry / Pyrazoles / CB 1 receptor / Piperidines / Molecular Conformation / Bioorganic and medicinal Chemistry / Pyrazoles / CB 1 receptor / Piperidines

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Imidazopyridines as VLA-4 integrin antagonists

Organic Chemistry / Pharmaceutical Chemistry / Humans / Mice / Animals / Drug Design / Rats / Phenylalanine / Pyridines / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Drug Design / Rats / Phenylalanine / Pyridines / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding

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Photosensitizer loaded HSA nanoparticles. I: Preparation and photophysical properties

Water / Pharmaceutical Technology / Scanning Electron Microscopy / Nanoparticles / Pharmaceutical Chemistry / Porphyrins / Adsorption / Pharmaceutics / Humans / Ethanol / Solubility / Photochemotherapy / Time Factors / Surface Properties / Freeze Drying / Singlet Oxygen / Bovine Serum Albumin / Drug Carriers / Drug Compounding / Drug Stability / Hydrogen-Ion Concentration / Solvents / Serum albumin / Porphyrins / Adsorption / Pharmaceutics / Humans / Ethanol / Solubility / Photochemotherapy / Time Factors / Surface Properties / Freeze Drying / Singlet Oxygen / Bovine Serum Albumin / Drug Carriers / Drug Compounding / Drug Stability / Hydrogen-Ion Concentration / Solvents / Serum albumin

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Bactericidal efficacy of liposomal aminoglycosides against Burkholderia cenocepacia

Microbiology / Flow Cytometry / Cystic Fibrosis / Medical Microbiology / Transmission Electron Microscopy / Drug Delivery System / Pharmaceutical Chemistry / Stability / Antibiotic Resistance / Lipids / Humans / Cholesterol / Bacteria / Temperature / Liposomes / Aminoglycosides / Fusion / Antimicrobial chemotherapy / Immunochemistry / Anti-Bacterial Agents / Burkholderia / Microbial Sensitivity Tests / Mechanism of action / Microbial Viability / Drug Stability / Burkholderia Cepacia Complex / Drug Delivery System / Pharmaceutical Chemistry / Stability / Antibiotic Resistance / Lipids / Humans / Cholesterol / Bacteria / Temperature / Liposomes / Aminoglycosides / Fusion / Antimicrobial chemotherapy / Immunochemistry / Anti-Bacterial Agents / Burkholderia / Microbial Sensitivity Tests / Mechanism of action / Microbial Viability / Drug Stability / Burkholderia Cepacia Complex

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Improving ex vivo skin permeation of non-steroidal anti-inflammatory drugs: Enhancing extemporaneous transformation of liposomes into planar lipid bilayers

Pharmaceutical Chemistry / Atomic Force Microscopy / Pharmaceutics / Humans / Female / Liposomes / Drug Delivery Systems / Skin / Ibuprofen / Surface Active Agents / Lipid bilayers / Liposomes / Drug Delivery Systems / Skin / Ibuprofen / Surface Active Agents / Lipid bilayers

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