Mouse Model - Page 6

Combined Deletion of Four Francisella novicida Acid Phosphatases Attenuates Virulence and Macrophage Vacuolar Escape

Survival Analysis / Macrophages / Biological Sciences / Infection and immunity / Spleen / Virulence / Cell line / Humans / Liver / Mice / Female / Animals / Infection / Gene Order / Francisella tularensis / Mouse Model / Virulence Factors / Cumulant / Virulence / Cell line / Humans / Liver / Mice / Female / Animals / Infection / Gene Order / Francisella tularensis / Mouse Model / Virulence Factors / Cumulant

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Frontonasal process-specific disruption of AP-2α results in postnatal midfacial hypoplasia, vascular anomalies, and nasal cavity defects

Developmental Biology / Face / Transcription Factors / Biological Sciences / Mental Retardation / Humans / Mice / Animals / Differentiation / Transcription Factor / Suture / Mouse Model / Nasal cavity / Blood Vessels / Base Sequence / DNA binding proteins / Birth Defect / Humans / Mice / Animals / Differentiation / Transcription Factor / Suture / Mouse Model / Nasal cavity / Blood Vessels / Base Sequence / DNA binding proteins / Birth Defect

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Macrophage Phospholipid Transfer Protein Contributes Significantly to Total Plasma Phospholipid Transfer Activity and Its Deficiency Leads to Diminished Atherosclerotic Lesion Development

Atherosclerosis / Phospholipids / Macrophages / Probability / Mice / Female / Animals / Bone marrow / Apolipoprotein E / apolipoprotein A-I / Clinical Sciences / Mouse Model / Deficiency / Sensitivity and Specificity / Deficit / Reference Values / Knockout Mice / Total Cholesterol / Lipid Transfer Proteins / foam cells / Female / Animals / Bone marrow / Apolipoprotein E / apolipoprotein A-I / Clinical Sciences / Mouse Model / Deficiency / Sensitivity and Specificity / Deficit / Reference Values / Knockout Mice / Total Cholesterol / Lipid Transfer Proteins / foam cells

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Macrophage Phospholipid Transfer Protein Contributes Significantly to Total Plasma Phospholipid Transfer Activity and Its Deficiency Leads to Diminished Atherosclerotic Lesion Development

Atherosclerosis / Phospholipids / Macrophages / Probability / Mice / Female / Animals / Bone marrow / Apolipoprotein E / apolipoprotein A-I / Clinical Sciences / Mouse Model / Deficiency / Sensitivity and Specificity / Deficit / Reference Values / Knockout Mice / Total Cholesterol / Lipid Transfer Proteins / foam cells / Female / Animals / Bone marrow / Apolipoprotein E / apolipoprotein A-I / Clinical Sciences / Mouse Model / Deficiency / Sensitivity and Specificity / Deficit / Reference Values / Knockout Mice / Total Cholesterol / Lipid Transfer Proteins / foam cells

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Activities of DL- -Difluoromethylarginine and Polyamine Analogues against Cryptosporidium parvum Infection in a T-Cell Receptor Alpha-Deficient Mouse Model

Microbiology / Medical Microbiology / T cell receptor / Polyamines / Mice / Animals / Behavioral Animal Models / Mouse Model / Antimicrobial agents / Arginine / Cryptosporidiosis / Animals / Behavioral Animal Models / Mouse Model / Antimicrobial agents / Arginine / Cryptosporidiosis

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Activities of DL--Difluoromethylarginine and Polyamine Analogues against Cryptosporidium parvum Infection in a T-Cell Receptor Alpha-Deficient Mouse Model

Microbiology / Medical Microbiology / T cell receptor / Mouse Model

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Efficacy of BAL5788, a Prodrug of Cephalosporin BAL9141, in a Mouse Model of Acute Pneumococcal Pneumonia

Microbiology / Medical Microbiology / Survival Analysis / Streptococcus pneumoniae / Prodrugs / Mice / Female / Animals / Cephalosporins / Lung / Spectrum / Mouse Model / Survival Rate / Microbial Sensitivity Tests / Body Weight / Water soluble polymers / Cumulant / Mice / Female / Animals / Cephalosporins / Lung / Spectrum / Mouse Model / Survival Rate / Microbial Sensitivity Tests / Body Weight / Water soluble polymers / Cumulant

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Pyruvate Kinase Deficiency and Malaria

Genetics / Coevolution / Global Health / England / Humans / Pyruvate Kinase / Mutation / Female / Animals / Drug Resistance / Male / Disease Control / Enzyme / Experimental Infection / Mouse Model / Energy Production / Phagocytosis / Adult / Plasmodium falciparum / Erythrocytes / New England Journalof Medicine / Hemolytic Anemia / Host Defense / Pyruvate Kinase / Mutation / Female / Animals / Drug Resistance / Male / Disease Control / Enzyme / Experimental Infection / Mouse Model / Energy Production / Phagocytosis / Adult / Plasmodium falciparum / Erythrocytes / New England Journalof Medicine / Hemolytic Anemia / Host Defense

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Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: Support for an endothelium-dependent mechanism

Cardiovascular / Immunohistochemistry / Cornea / Animals / Vehicle dynamic control / Vascular endothelium / Behavioral Animal Models / Mouse Model / Rats / Endothelial cell / Blood Flow / DR-AR Model / Biological markers / Rat Model / Aorta / Cell Survival / Blood Vessel / Vascular Endothelial Growth Factor / Vascular endothelium / Behavioral Animal Models / Mouse Model / Rats / Endothelial cell / Blood Flow / DR-AR Model / Biological markers / Rat Model / Aorta / Cell Survival / Blood Vessel / Vascular Endothelial Growth Factor

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Generalized CNS disease and massive GM1-ganglioside accumulation in mice defective in lysosomal acid β-galactosidase

Genetics / Biological Sciences / Brain / Humans / Mice / Animals / Spinal Cord / Embryonic Stem Cell / Human Molecular Genetics / Mouse Model / Homologous Recombination / Human Disease / Glycosphingolipids / Gangliosides / Animals / Spinal Cord / Embryonic Stem Cell / Human Molecular Genetics / Mouse Model / Homologous Recombination / Human Disease / Glycosphingolipids / Gangliosides

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Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice

Atherosclerosis / Membrane Proteins / Transgenic Mice / Humans / Mice / Female / Animals / Male / Apolipoprotein E / Risk factors / Lipoprotein(a) / Clinical Sciences / Mouse Model / Risk Factors / Cell Formation / Female / Animals / Male / Apolipoprotein E / Risk factors / Lipoprotein(a) / Clinical Sciences / Mouse Model / Risk Factors / Cell Formation

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JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells

Immunohistochemistry / DNA damage / Apoptosis / Cell Division / Cell line / Humans / Nitric oxide / Blood / Multiple Myeloma / Clinical Sciences / Comet Assay / Mouse Model / DNA damage response / Tumor Growth / Clinical evaluation / Insulin Like Growth Factor / Bone marrow stromal cells / DNA double strand breaks / Humans / Nitric oxide / Blood / Multiple Myeloma / Clinical Sciences / Comet Assay / Mouse Model / DNA damage response / Tumor Growth / Clinical evaluation / Insulin Like Growth Factor / Bone marrow stromal cells / DNA double strand breaks

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JS-K, a GST-activated nitric oxide generator, induces DNAdouble-strand breaks, activates DNAdamage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells

Immunohistochemistry / DNA damage / Apoptosis / Cell Division / Cell line / Humans / Nitric oxide / Blood / Multiple Myeloma / Clinical Sciences / Comet Assay / Mouse Model / DNA damage response / Tumor Growth / Clinical evaluation / Insulin Like Growth Factor / Bone marrow stromal cells / DNA double strand breaks / Humans / Nitric oxide / Blood / Multiple Myeloma / Clinical Sciences / Comet Assay / Mouse Model / DNA damage response / Tumor Growth / Clinical evaluation / Insulin Like Growth Factor / Bone marrow stromal cells / DNA double strand breaks

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Bone loss in survival motor neuron ( Smn −/− SMN2 ) genetic mouse model of spinal muscular atrophy

Genetics / Pathology / Gene expression / Signal Transduction / Spinal Muscular Atrophy / Mice / Tibia / Animals / Three Dimensional Imaging / Osteoclasts / Bone Density / The / Behavioral Animal Models / Clinical Sciences / Mouse Model / Bone Loss / Biological markers / Bone remodeling / X ray Computed Tomography / Mice / Tibia / Animals / Three Dimensional Imaging / Osteoclasts / Bone Density / The / Behavioral Animal Models / Clinical Sciences / Mouse Model / Bone Loss / Biological markers / Bone remodeling / X ray Computed Tomography

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Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition

Breast Cancer / DNA damage / Western blotting / Humans / Mice / Female / Animals / Male / Cell Death / Phosphorylation / Mouse Model / Homologous Recombination / Benzimidazoles / Female / Animals / Male / Cell Death / Phosphorylation / Mouse Model / Homologous Recombination / Benzimidazoles

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Perivascular application of C-type natriuretic peptide attenuates neointimal hyperplasia in experimental vein grafts

Mice / Animals / Male / Hyperplasia / Morphometric Analysis / European / Mouse Model / Inferior Vena Cava / Topical Drug Administration / Calcium Binding Proteins / Vascular Endothelial Function / Control Group / European / Mouse Model / Inferior Vena Cava / Topical Drug Administration / Calcium Binding Proteins / Vascular Endothelial Function / Control Group

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