Clinical Investigation

In vivo correction of ZAP-70 immunodeficiency by intrathymic gene transfer

Hematopoietic Stem Cells / Humans / Mice / Animals / Clinical / Lentivirus / T lymphocytes / Clinical Investigation / Severe combined immunodeficiency / Gene Transfer / Lentivirus / T lymphocytes / Clinical Investigation / Severe combined immunodeficiency / Gene Transfer

5′RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy

Transcriptome / Humans / Mice / Female / Animals / Male / Myocardium / Clinical Investigation / Male / Myocardium / Clinical Investigation

The antimalarial action of desferal involves a direct access route to erythrocytic (Plasmodium falciparum) parasites

Kinetics / Humans / Animals / Plasmodium falciparum / Antimalarials / Erythrocyte Membrane / Erythrocytes / Drug Carriers / Clinical Investigation / Molecular Structure / Erythrocyte Membrane / Erythrocytes / Drug Carriers / Clinical Investigation / Molecular Structure

Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models

Clinical Investigation

AKT activation promotes PTEN hamartoma tumor syndrome–associated cataract development

Aging / Mice / Animals / Cataract / Sodium / Disease Progression / Ion Transport / Clinical Investigation / Hydrostatic Pressure / Disease Progression / Ion Transport / Clinical Investigation / Hydrostatic Pressure

Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

Prostate Cancer / Cell Differentiation / Humans / Transient receptor potential channels / Clinical / Male / Endoplasmic Reticulum / Alternative splicing / Prostate / Subcellular Localization / Epithelial cells / Alternative Splicing / Protein isoforms / Base Sequence / Subcellular Fractions / Clinical Investigation / Plasma Membrane / Male / Endoplasmic Reticulum / Alternative splicing / Prostate / Subcellular Localization / Epithelial cells / Alternative Splicing / Protein isoforms / Base Sequence / Subcellular Fractions / Clinical Investigation / Plasma Membrane

Kidney kinase network regulates renal ion cotransport

Signal Transduction / Kidney / Homeostasis / Sodium / Phosphates / Ion Transport / Clinical Investigation / Ion Transport / Clinical Investigation

Activity of [des-Aspartyl1]-Angiotensin II in Primary Aldosteronism

Humans / Blood Pressure / Aldosterone / Potassium / Posture / Angiotensin II / Clinical Investigation / Hyperaldosteronism / Angiotensin II / Clinical Investigation / Hyperaldosteronism

CX3CR1-dependent renal macrophage survival promotes Candida control and host survival

Macrophages / Apoptosis / Chemokines and chemokine receptors / Humans / Kidney / Mice / United States / Female / Animals / Male / Candida albicans / Netherlands / Risk factors / Behavioral Animal Models / Monocytes / Risk Factors / Host Pathogen Interactions / Clinical Investigation / Adoptive Transfer / Mice / United States / Female / Animals / Male / Candida albicans / Netherlands / Risk factors / Behavioral Animal Models / Monocytes / Risk Factors / Host Pathogen Interactions / Clinical Investigation / Adoptive Transfer

Alzheimer disease β-amyloid activity mimics cholesterol oxidase

Brain / Humans / Copper / Mice / Cholesterol / Animals / Clinical / Male / Neurons / Aged / Adult / Chelating Agents / Alzheimer Disease / Clinical Investigation / Oxidation-Reduction / Molecular Structure / Animals / Clinical / Male / Neurons / Aged / Adult / Chelating Agents / Alzheimer Disease / Clinical Investigation / Oxidation-Reduction / Molecular Structure

Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model

Cystic Fibrosis / Humans / Animals / Clinical / Gene transfer techniques / Staphylococcus aureus / Cell Transplantation / Pseudomonas aeruginosa / Anti-Bacterial Agents / Antimicrobial Cationic Peptides / Chickens / Swine / HeLa cells / Pseudomonas Aeruginosa / Clinical Investigation / Staphylococcus aureus / Cell Transplantation / Pseudomonas aeruginosa / Anti-Bacterial Agents / Antimicrobial Cationic Peptides / Chickens / Swine / HeLa cells / Pseudomonas Aeruginosa / Clinical Investigation

Increased C5a receptor expression in sepsis

Immunohistochemistry / Antibodies / Kidney / Liver / Mice / Animals / Clinical / Male / Sepsis / Lung / Neutrophils / Myocardium / Clinical Investigation / Animals / Clinical / Male / Sepsis / Lung / Neutrophils / Myocardium / Clinical Investigation

Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility

Enzyme Inhibitors / Humans / Meiosis / Mice / cyclic AMP / Female / Ovulation / Animals / Clinical / Phosphodiesterase Inhibitors / Isoenzymes / Cyclic nucleotides / Ovary / Oocytes / Female Infertility / Clinical Investigation / Female / Ovulation / Animals / Clinical / Phosphodiesterase Inhibitors / Isoenzymes / Cyclic nucleotides / Ovary / Oocytes / Female Infertility / Clinical Investigation

Double minutes arise from circular extrachromosomal DNA intermediates which integrate into chromosomal sites in human HL-60 leukemia cells

Cell Division / Humans / Nucleic acid hybridization / Plasmids / Oncogenes / Clinical Investigation

Double minutes arise from circular extrachromosomal DNA intermediates which integrate into chromosomal sites in human HL-60 leukemia cells

Cell Division / Humans / Nucleic acid hybridization / Plasmids / Oncogenes / Clinical Investigation

The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon

Aldosterone / Animals / Clinical / Male / Behavioral Animal Models / Rats / Sodium / Time Factors / Voltage-Gated Sodium Channels / Body Weight / Clinical Investigation / Creatinine / Rats / Sodium / Time Factors / Voltage-Gated Sodium Channels / Body Weight / Clinical Investigation / Creatinine

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