Amino Acid Substitution Rates - Page 6

A proximal tryptophan in NO synthase controls activity by a novel mechanism

Inorganic Chemistry / Kinetics / Cytochrome C / Spectrophotometry / Tryptophan / Heme / Enzyme / Steady state / Hydrogen Bond / Hydrogen Bonding / Nitric Oxide Synthase / Cysteine / Molecular Conformation / Protein Conformation / Inorganic Biochemistry / Amino Acid Substitution Rates / Recombinant Proteins / Site-directed Mutagenesis / Binding affinity / Heme / Enzyme / Steady state / Hydrogen Bond / Hydrogen Bonding / Nitric Oxide Synthase / Cysteine / Molecular Conformation / Protein Conformation / Inorganic Biochemistry / Amino Acid Substitution Rates / Recombinant Proteins / Site-directed Mutagenesis / Binding affinity

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Effects of amino acid substitution polymorphisms of two DNA methyltransferases on susceptibility to sporadic colorectal cancer

Polymorphism / Colorectal cancer / Iran / Humans / Female / Male / Polymerase Chain Reaction / DNA methylation / Asian-Pacific Region / Middle Aged / Genotype / Adult / Public health systems and services research / Amino Acid Substitution Rates / Genetic Susceptibility / Allele Frequency / Case Control Studies / Colorectal Neoplasms / Male / Polymerase Chain Reaction / DNA methylation / Asian-Pacific Region / Middle Aged / Genotype / Adult / Public health systems and services research / Amino Acid Substitution Rates / Genetic Susceptibility / Allele Frequency / Case Control Studies / Colorectal Neoplasms

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Amino Acid Encoding Schemes from Protein Structure Alignments: Multi-dimensional Vectors to Describe Residue Types

Algorithms / Theoretical biology / Biological Sciences / Humans / Sequence alignment / Color / Mathematical Sciences / Animals / Amino Acid Profile / Multiple Sequence Alignment / Amino Acid Sequence / Amino Acid Substitution Rates / Model Complexity / Multi Dimensional / Artificial Neural Network / Visual Inspection / Color / Mathematical Sciences / Animals / Amino Acid Profile / Multiple Sequence Alignment / Amino Acid Sequence / Amino Acid Substitution Rates / Model Complexity / Multi Dimensional / Artificial Neural Network / Visual Inspection

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Dimerization Determines Substrate Specificity of a Bacterial Prenyltransferase

Protein Engineering / Temperature / Bacillus subtilis / Substrate Specificity / Amino Acid Substitution Rates / Protein Quaternary Structure / Biochemistry and cell biology / Protein Quaternary Structure / Biochemistry and cell biology

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Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: Intra-familial association study in an eight-generation hyperlipidemic kindred

Genetics / Association study / Humans / Female / Male / Plasma / American / Pedigree / Phenotype / Clinical Sciences / Association / Middle Aged / Snp / Adult / Single Nucleotide Polymorphism / Lipoproteins / Growth Hormone Receptor / Genetic variation / Familial Hypercholesterolemia / Codon / Amino Acid Substitution Rates / Variant / Plasma / American / Pedigree / Phenotype / Clinical Sciences / Association / Middle Aged / Snp / Adult / Single Nucleotide Polymorphism / Lipoproteins / Growth Hormone Receptor / Genetic variation / Familial Hypercholesterolemia / Codon / Amino Acid Substitution Rates / Variant

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Amino Acid Residues Critical for Endoplasmic Reticulum Export and Trafficking of Platelet-activating Factor Receptor

Biological Chemistry / Biological Sciences / Humans / G protein-coupled receptors / Animals / Biological / Endoplasmic Reticulum / Proline / CHEMICAL SCIENCES / HeLa cells / Amino Acid Profile / Triazoles / Amino Acid Substitution Rates / Protein Transport / Gene Expression Regulation / Biological / Endoplasmic Reticulum / Proline / CHEMICAL SCIENCES / HeLa cells / Amino Acid Profile / Triazoles / Amino Acid Substitution Rates / Protein Transport / Gene Expression Regulation

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A double mutant [N543H+2393del9] allele in the LDL receptor gene in familial hypercholesterolemia: effect on plasma cholesterol levels and cardiovascular disease

Genetics / Cardiovascular disease / Human / DNA / Humans / Mutation / Cholesterol / Female / Male / Pedigree / Phenotype / Triglycerides / Clinical Sciences / Aged / Middle Aged / Genotype / Adult / Cardiovascular Diseases / Familial Hypercholesterolemia / Amino Acid Substitution Rates / DNA mutational analysis / Mutation / Cholesterol / Female / Male / Pedigree / Phenotype / Triglycerides / Clinical Sciences / Aged / Middle Aged / Genotype / Adult / Cardiovascular Diseases / Familial Hypercholesterolemia / Amino Acid Substitution Rates / DNA mutational analysis

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In vitro induction of human immunodeficiency virus type 1 variants resistant to phosphoralaninate prodrugs of Z-methylenecyclopropane nucleoside analogues

Microbiology / Medical Microbiology / HIV / Prodrugs / Animals / Microbial genetic and drug resistance / Specific Activity / Antimicrobial agents / Microbial Sensitivity Tests / Alanine / Amino Acid Sequence / Amino Acid Substitution Rates / Reverse Transcriptase / Molecular Sequence Data / Microbial genetic and drug resistance / Specific Activity / Antimicrobial agents / Microbial Sensitivity Tests / Alanine / Amino Acid Sequence / Amino Acid Substitution Rates / Reverse Transcriptase / Molecular Sequence Data

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Recombinant Plasmepsin 1 from the Human Malaria Parasite Plasmodium falciparum : Enzymatic Characterization, Active Site Inhibitor Design, and Structural Analysis

Biochemistry / Catalysis / Kinetics / Enzyme Inhibitors / Humans / Animals / Structure Analysis / Solubility / Active site / Substrate Specificity / Plasmodium falciparum / Protozoan Proteins / Amino Acid Sequence / Amino Acid Substitution Rates / Structure activity Relationship / Recombinant Proteins / Hydrogen-Ion Concentration / Biochemistry and cell biology / Molecular Structure / Molecular Sequence Data / Animals / Structure Analysis / Solubility / Active site / Substrate Specificity / Plasmodium falciparum / Protozoan Proteins / Amino Acid Sequence / Amino Acid Substitution Rates / Structure activity Relationship / Recombinant Proteins / Hydrogen-Ion Concentration / Biochemistry and cell biology / Molecular Structure / Molecular Sequence Data

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Recombinant Plasmepsin 1 from the Human Malaria Parasite Plasmodium falciparum : Enzymatic Characterization, Active Site Inhibitor Design, and Structural Analysis

Biochemistry / Catalysis / Kinetics / Enzyme Inhibitors / Humans / Animals / Structure Analysis / Solubility / Active site / Substrate Specificity / Plasmodium falciparum / Protozoan Proteins / Amino Acid Sequence / Amino Acid Substitution Rates / Structure activity Relationship / Recombinant Proteins / Hydrogen-Ion Concentration / Biochemistry and cell biology / Molecular Structure / Molecular Sequence Data / Animals / Structure Analysis / Solubility / Active site / Substrate Specificity / Plasmodium falciparum / Protozoan Proteins / Amino Acid Sequence / Amino Acid Substitution Rates / Structure activity Relationship / Recombinant Proteins / Hydrogen-Ion Concentration / Biochemistry and cell biology / Molecular Structure / Molecular Sequence Data

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Poliovirus Polymerase Residue 5 Plays a Critical Role in Elongation Complex Stability

Virology / Biological Sciences / Humans / Virus / Amino Acid Substitution Rates / Site-directed Mutagenesis / Poliovirus / Site-directed Mutagenesis / Poliovirus

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Identification of Pore Residues Engaged in Determining Divalent Cationic Permeation in Transient Receptor Potential Melastatin Subtype Channel 2

Calcium / Biological Chemistry / Biological Sciences / Cell line / Humans / Magnesium / Permeability / Transient receptor potential channels / Biological / D-Aspartic Acid / CHEMICAL SCIENCES / Sodium / Ion Transport / Amino Acid Substitution Rates / Glutamic Acid / Magnesium / Permeability / Transient receptor potential channels / Biological / D-Aspartic Acid / CHEMICAL SCIENCES / Sodium / Ion Transport / Amino Acid Substitution Rates / Glutamic Acid

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From malate dehydrogenase to phenyllactate dehydrogenase. Incorporation of unnatural amino acids to generate an improved enzyme-catalyzed activity

Catalysis / Kinetics / Biological Chemistry / Protein Engineering / Biological Sciences / Escherichia coli / CHEMICAL SCIENCES / Substrate Specificity / Arginine / Alkylation / Amino Acid Substitution Rates / Site-directed Mutagenesis / Escherichia coli / CHEMICAL SCIENCES / Substrate Specificity / Arginine / Alkylation / Amino Acid Substitution Rates / Site-directed Mutagenesis

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A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan

Medical Microbiology / Pakistan / Malaria / Adolescent / Humans / Child / Female / Drug Resistance / Male / Polymerase Chain Reaction / Young Adult / Infant / Gene Dosage / Aged / Middle Aged / Genotype / Adult / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Amino Acid Substitution Rates / Child preschool / Child / Female / Drug Resistance / Male / Polymerase Chain Reaction / Young Adult / Infant / Gene Dosage / Aged / Middle Aged / Genotype / Adult / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Amino Acid Substitution Rates / Child preschool

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Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease

Cognitive Science / Neurology / Humans / Haplotypes / Female / Male / Clinical Sciences / Aged / Middle Aged / Adult / Internationality / Arginine / Cysteine / Glycine / Amino Acid Substitution Rates / Neurosciences / Parkinson Disease / DNA mutational analysis / Male / Clinical Sciences / Aged / Middle Aged / Adult / Internationality / Arginine / Cysteine / Glycine / Amino Acid Substitution Rates / Neurosciences / Parkinson Disease / DNA mutational analysis

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A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan

Medical Microbiology / Pakistan / Malaria / Adolescent / Humans / Child / Female / Drug Resistance / Male / Polymerase Chain Reaction / Young Adult / Infant / Gene Dosage / Aged / Middle Aged / Genotype / Adult / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Amino Acid Substitution Rates / Child preschool / Child / Female / Drug Resistance / Male / Polymerase Chain Reaction / Young Adult / Infant / Gene Dosage / Aged / Middle Aged / Genotype / Adult / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Amino Acid Substitution Rates / Child preschool

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