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Alanine
Alanine
Scanning Alanine Mutagenesis and De-peptidization of a Candida albicans Myristoyl-CoA:Protein N-Myristoyltransferase Octapeptide Substrate Reveals Three Elements Critical for Molecular Recognition
Kinetics / Biological Chemistry / Biological Sciences / Candida albicans / CHEMICAL SCIENCES / Substrate Specificity / Alanine / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Substrate Specificity / Alanine / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins
Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase
Physiology / Calcium / Enzyme Inhibitors / Flavonoids / Dogs / Nitriles / Permeability / Animals / Potassium / Phosphorylation / Medical Physiology / Organophosphorus Compounds / Epithelial cells / Time Factors / Swine / Transfection / Alanine / Protein Kinase Inhibitors / Biochemistry and cell biology / Ouabain / Nitriles / Permeability / Animals / Potassium / Phosphorylation / Medical Physiology / Organophosphorus Compounds / Epithelial cells / Time Factors / Swine / Transfection / Alanine / Protein Kinase Inhibitors / Biochemistry and cell biology / Ouabain
d -Amino Acid Chemical Reporters Reveal Peptidoglycan Dynamics of an Intracellular Pathogen
Molecular Dynamics Simulation / Biological Sciences / Click chemistry / Listeria monocytogenes / CHEMICAL SCIENCES / Molecular Conformation / Alanine / Peptidoglycan / Molecular Conformation / Alanine / Peptidoglycan
Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli
Enzyme Inhibitors / Biological Sciences / Humans / Protein Kinases / Escherichia coli / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure
Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1 H-pyrrolo[1,2- c]imidazol-1-ones: A new class of Neuropeptide S antagonists
Inorganic Chemistry / Organic Chemistry / Medicinal Chemistry / Calcium / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure / Macromolecular X-Ray Crystallography / Patch-clamp and imaging techniques / Dogs / Cell line / Adenosine / Brain / Humans / Discrimination Learning / Cerebral Cortex / Mice / Nicotine / Animals / Male / Nicotinic Acetylcholine Receptors / Organometallics / Neurons / CHEMICAL SCIENCES / Rats / Radioligand Assay / Pyridines / BIOCHEMICAL PHARMACOLOGY / Molecular Conformation / Protein Conformation / Alanine / Bioorganic and medicinal Chemistry / Radiopharmaceuticals / Rabbits / Structure activity Relationship / Recombinant Proteins / Ligands / Pain Measurement / Monte Carlo Method / Analgesics / Molecular Structure
Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli
Enzyme Inhibitors / Biological Sciences / Humans / Protein Kinases / Escherichia coli / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure / Pseudomonas aeruginosa / CHEMICAL SCIENCES / Anti-Bacterial Agents / Microbial Sensitivity Tests / Pseudomonas Aeruginosa / Alanine / Pyrazoles / Structure activity Relationship / Molecular Structure
Manganese superoxide dismutase (MnSOD: Ala–9Val) gene polymorphism and mood disorders: A preliminary study
Humans / Female / Male / Superoxide Dismutase / Mood Disorders / Middle Aged / Adult / Chi Square Distribution / Alanine / Middle Aged / Adult / Chi Square Distribution / Alanine
Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists
Organic Chemistry / Humans / Propionic Acid / Alanine / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Biological Availability / Structure activity Relationship / Protein Binding / Biological Availability
Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist
Analytical Chemistry / Organic Chemistry / Electrophysiology / Macromolecular X-Ray Crystallography / Chirality / Glutamate receptors / Female / Animals / Propionic Acid / High Pressure Liquid Chromatography / Molecular cloning / Rats / Radioligand Assay / Xenopus laevis / Protein Conformation / Alanine / Oocytes / Structure activity Relationship / Recombinant Proteins / Molecular Structure / Glutamate receptors / Female / Animals / Propionic Acid / High Pressure Liquid Chromatography / Molecular cloning / Rats / Radioligand Assay / Xenopus laevis / Protein Conformation / Alanine / Oocytes / Structure activity Relationship / Recombinant Proteins / Molecular Structure
A lesson in efficient killing from two-component lantibiotics
Molecular Microbiology / Biological Sciences / Bacteriocins / Sulfides / Anti-Bacterial Agents / Nisin / Alanine / Mechanism of action / Cell Wall / Nisin / Alanine / Mechanism of action / Cell Wall
A single amino acid residue, Ala 105, confers 16α-hydroxylase activity to human cytochrome P450 17α-hydroxylase/17,20 lyase
Homology Modeling / Cercopithecus aethiops / Progesterone / Humans / Sequence alignment / Animals / Iron / Enzyme / Goats / Amino Acid Profile / Alanine / Species Specificity / Amino Acid Sequence / Amino Acid Substitution Rates / Sus Scrofa / Protein Binding / Biochemistry and cell biology / Animals / Iron / Enzyme / Goats / Amino Acid Profile / Alanine / Species Specificity / Amino Acid Sequence / Amino Acid Substitution Rates / Sus Scrofa / Protein Binding / Biochemistry and cell biology
Amino Acid Residue 149of Lecithin:Cholesterol Acyltransferase Determines Phospholipase A2 and Transacylase Fatty Acyl Specificity
Biological Chemistry / Biological Sciences / Papio / Humans / Sequence alignment / Animals / Biological / CHEMICAL SCIENCES / Rats / Substrate Specificity / Alanine / Amino Acid Sequence / Animals / Biological / CHEMICAL SCIENCES / Rats / Substrate Specificity / Alanine / Amino Acid Sequence
Electrogenic amino acid exchange via the rBAT transporter
Female / Animals / Molecular cloning / Amino Acids / Xenopus laevis / Arginine / Amino Acid Profile / Alanine / Rabbits / Base Sequence / Oocytes / Recombinant Proteins / Biochemistry and cell biology / Arginine / Amino Acid Profile / Alanine / Rabbits / Base Sequence / Oocytes / Recombinant Proteins / Biochemistry and cell biology
Increased insulin clearance in peroxisome proliferator-activated receptor γ2 Pro12Ala
Metabolism / Polymorphism / Transcription Factors / Adipose tissue / Humans / Insulin / Female / Male / Peroxisome proliferator-activated receptor / Steady state / Clinical Sciences / Adult / Risk Reduction / Oral Glucose Tolerance Test / Alanine / Free Fatty Acid / Glucose Tolerance Test / Type 2 Diabetes Mellitus / Insulin / Female / Male / Peroxisome proliferator-activated receptor / Steady state / Clinical Sciences / Adult / Risk Reduction / Oral Glucose Tolerance Test / Alanine / Free Fatty Acid / Glucose Tolerance Test / Type 2 Diabetes Mellitus
Experimental colitis decreases rat jejunal amino acid absorption
Life Sciences / Intestinal Mucosa / Ulcerative colitis / Female / Animals / Male / Jejunum / Capsaicin / Denervation / Colitis / Intestinal absorption / Rats / Time Factors / Amino Acid Profile / Alanine / Small Intestine / Biochemistry and cell biology / Vagus Nerve / Male / Jejunum / Capsaicin / Denervation / Colitis / Intestinal absorption / Rats / Time Factors / Amino Acid Profile / Alanine / Small Intestine / Biochemistry and cell biology / Vagus Nerve
Allosteric 1-Adrenoreceptor Antagonism by the Conopeptide -TIA
Kinetics / Fluorescence Microscopy / Biological Chemistry / Biological Sciences / Smooth muscle / Animals / Male / Peptides / CHEMICAL SCIENCES / Rats / Time Factors / Arginine / Wistar Rats / Protein Conformation / Alanine / Amino Acid Sequence / Structure activity Relationship / Protein Binding / Binding Site / Full Length Movies / Animals / Male / Peptides / CHEMICAL SCIENCES / Rats / Time Factors / Arginine / Wistar Rats / Protein Conformation / Alanine / Amino Acid Sequence / Structure activity Relationship / Protein Binding / Binding Site / Full Length Movies
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