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Reversal of Adriamycin Resistance by Recombinant «Interferon in Multidrug- resistant Human Colon Carcinoma LoVo-DoxorubicinCells1

May 28, 2017 | Autor: Stefania Scala | Categoría: Kinetics, Cancer, Cell Cycle, Gene expression, Cell Division, Cell line, Cell Differentiation, Humans, Low Dose, Multidrug Resistance, Drug Resistance, P-glycoprotein, Doxorubicin, Monoclonal Antibody, Colon Carcinoma, Recombinant Proteins, Cell Surface Markers, Cell Survival, Adenocarcinoma, Cell line, Cell Differentiation, Humans, Low Dose, Multidrug Resistance, Drug Resistance, P-glycoprotein, Doxorubicin, Monoclonal Antibody, Colon Carcinoma, Recombinant Proteins, Cell Surface Markers, Cell Survival, Adenocarcinoma
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Reversal of the drug resistance phenotype by the use of agents which induce cell differentiation offers an experimental approach to the study of chemoresistance. In numerous in vitro models, a-interferon (a-IFN) has been shown to induce phenotypical changes and to modulate the growth of cancer cells. The aim of the present study was to define the effect of a-IFN on
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