Regioselective synthesis of angular nitrogen polyheterocycles: dipyrido[3,2-a:2′,3′-c]quinolino[2,3-h]phenazines

2002

Phenazine derivatives

Phenazine derivatives R 0570 Regioselective Synthesis of Angular Nitrogen Polyheterocycles: Dipyrido[3,2-a:2',3'-c]quinolino[2,3-h]phenazines. — The synthesis of o-diamines of type 04- 158 (IV) and their conversion to pentaaza heptacycles (VI) is described. Compounds (VIa), (VIb) exhibit DNA cleavage properties similarly to those known for phenanthroline in the presence of Cu(I). — (DINICA, R.; CHARMANTRAY, F.; DEMEUNYNCK*, M.; DUMY, P.; Tetrahedron Lett. 43 (2002) 44, 7883-7885; Lab. Etud. Dyn. Struct. Sel., CNRS, Univ. Joseph Fourier, F-38041 Grenoble, Fr.; Eng.) — Mais