PP-43. Neuron-specific enolase is cesarean deliveries performed for fetal distress

Abstracts

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Conclusions

Aim

Even common routine procedures can be potentially harmful for the newborn if they provoke a high level of pain. This study adds new evidence to support the use of effective analgesic procedures for every type of potentially painful event, in order to avoid the dangerous effects of oxidative stress related to FR generation.

Neuron-specific enolase (NSE) is a sensitive marker of brain injury after hypoxia–ischemia. Our aims were to investigate the postnatal time course of NSE levels in serum and to determine association between with the cesarean deliveries performed for fetal distress (CDPFD). Materials and methods

doi:10.1016/j.earlhumdev.2010.09.094

PP-42. The peculiarities of immune status (IS) disturbances in newborns with perinatal lesion of central nervous system (CNS) Afaq Safarova, Nasib Guliyev Azerbaijan Medical University Department of Children Diseases, Azerbaijan Aim The research was aimed to study IS disturbances in newborns depending on degree of severity of perinatal pathology (hypoxia). Materials and methods The research was conducted on 125 newborns, divided into four groups according to gestational age: I—25 premature newborns with high perinatal risks, II—25 mature newborns with high perinatal risks, III—25 newborns with intrauterine growth retardation high perinatal risks, IV—50 healthy mature (25) and premature (25) newborns. All newborns from the first 3 groups underwent clinical assessment of severity of condition, perinatal and intranatal aggravating factors identification, presence of neurological symptoms and syndromes, laboratory and instrumental (neurosonography, EEG, ECG, echocardiography, and spinal fluid puncture) examinations, and eyeground tests. 65 newborns from all groups (15 from groups I–III and 20 from IV) underwent laser cytofluorometry IS by “Faxsan” from “Becton Dickinson” (Belgium). The relative and absolute numbers of T-(CD3+) and B-(CD9+) lymphocytes, their subpopulations (T-helpers—CD4+, T-suppressors—CD8+, and natural killers—CD16+/CD56+) along with levels of circulating immune complexes (CIC), Il-6 and IL-10 on «Elisa» after childbirths and going home (10–14 days). Results The data we obtained shows that the IS identifiers correlate with the severity of perinatal pathology (hypoxemia). Conclusions IS identifiers can be used as criteria to assess hypoxic lesion to CNS and residual cerebral insufficiency in newborns. doi:10.1016/j.earlhumdev.2010.09.095

The study was performed from June to December 2009 in our hospital and was approved by the Institutional Ethical Committee. In our study, in the first group 29 neonates (36–42 weeks of gestation) born by CDPFD; in the second group 26 neonates at same gestational ages born by elective cesarean; in the third group 20 healthy term neonates born vaginally were included. NSE serum levels were examined in umbilical cord blood at birth and in peripheral venous blood at the 24th hour of life. Statistical analyses were made using NCSS (Number Cruncher Statistical System) 2007 and PASS 2008 Statistical Software (Utah, USA). p < 0.05 was considered significant. Results The characteristic features (gestational age, birthweight, and sex) were similar in all groups: median gestational age and birthweight were 39.23 ± 1.29 weeks, 3251 ± 472 g (p > 0.05). In three groups APGAR scores were 7.72 ± 1.64, 8.04 ± 1.21 and 8.85 ± 0.36 at 1 min and 9.41 ± 0.63, 9.46 ± 0.65, 9.9 ± 0.31 at 5 min respectively (p < 0.01). APGAR scores were significantly higher in vaginal birth. The NSE levels were 94.17 ± 47.05, 31.55 ± 32.86, 19.69 ± 16.03 at birth and the levels at the 24th hour of life were 30.44 ± 12.66, 11.59 ± 7.92, 11.63 ± 6.81 in three groups respectively (p < 0.01). The NSE levels were significantly elevated in neonates born by CDPFD at birth and the 24th hour of life. In all groups NSE levels were lower at the 24th hour of life than at the birth and were statistically significant (p < 0.01). Conclusions We conclude that NSE can be a predictive value for neuronal damage that can be used for assessment of neonates born after CDPFD to be suspected for perinatal asphyxia. Further studies are needed. doi:10.1016/j.earlhumdev.2010.09.096

PP-44. Neurological outcome at 2 years of age in extremely low birth weight infants at a tertiary care hospital in Porto Andreia Leitaoa, Ana Vilana, Sandra Costaa, Sofia Aguedaa, Beatriz Guedesa, Hercília Guimarãesb a Hospital De S.João, Portugal b Faculty of Medicine of Porto, Portugal Aim

PP-43. Neuron-specific enolase is cesarean deliveries performed for fetal distress Zeliha Kucuktasa, Ozgul Salihoglua, Begum Sirin Koca, Esra Sevketoglua, Levent Yasarb, Sami Hatipoglua a Bakırköy Dr Şadi Konuk Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey b Department of Gynecology and Obstetrics, Turkey

Before the era of neonatal intensive care, when few extremely low birth weight (ELBW) infants survived, the majority was described as having average or above-average mental development. More recent reports, however, indicated that fewer persons with ELBW than normal birth weight controls had graduated from high school. Our aim was to study cognitive and neurological outcome of ELBW infants at 2 years of age in relation to neonatal data and to neuroimagiological examinations.