Paracetamol Lozenges

Comment

Purpose Of Study

Paracetamol was formulated as lozenges to provide slow release medicament for the management of fever and pain.

There are many dosage forms like syrups, tablets, inhalers are available in the market but still there is a need for new dosage forms which acts effectively and locally. So the present investigation has been taken up to design, prepare and evaluated tablet lozenges to meet the need of improved bioavailability and hence avoid hepatic toxicity.

The benefits of these prepared lozenges showed increase in bioavailability, reduction in gastric irritation by passing of 1 pass metabolism and increase in onset of action.
Introduction

Lozenges are flavoured medicated dosage form intended to be sucked and held in mouth. They provide ease of administration for paediatric patients.The drugs having a large dose can be easily administered formulating as lozenges. Patient compliance is high with buccal delivery due to the accessibility of the cheek and lack of invasive measures .Most of the illness is associated with high body temperature, fever, head ache and body ache. It is very difficult to manage these complications in pediatrics patients.This investigation deals with formulation of medicated sugar based lozenges containing the most common antipyretic and analgesic drug paracetamol.
Objective

Paracetamol Lozenges particularly suitable for very young children.There is only limited knowledge available on the acceptability of different dosage forms, administration volumes, dosage form size, taste, and importantly, the acceptability and safety of formulation excipients in relation to the age and development status of the child.

Many medicinal products are not currently available in formulations suitable for administration to the paediatric population. Consequently, healthcare professionals frequently resort to the preparation and administration of unlicensed formulations by manipulation of adult dosage forms.

Paracetamol Lozenges contain only excipients that known to be safe and effective for the age of the paediatric patient.
Dosage forms safely and effectively adapted to the needs of paediatric patients.if appropriate commercial dosage forms are not available.

Formulation
Ingredients
Amount
Sucrose
30.25g
Dextrose
15g
Paracetamol
1g
HPMC K4
3.25g
Citric Acid
0.5g
Process
Required quantity of sugar syrup was prepared mixing sugar and water (9ml-10ml)


Dextrose was dissolved in small quantity (4ml-5ml) of water and heated it to 110c till dextrose dissolves completel forming as clear viscous syrup.


Cont.
Then the dextrose solution was poured into the sugar syrup and heated to 160c till the colour changes to golden yellow.

The temperature was bought down to 90c
and drug,polymer and other ingredients were added.

Result

Paracetamol Lozenges


Cont.
The solution was poured into the mould having 2.8cm diameter and 6.5mm thickness. The prepared tablets were stored wrapped in aluminium foil and stored in desiccators to prevent moisture uptake. The final weight of each lozenge is 5gms.


Click to edit Master title style
Click to edit Master text styles
Second level
Third level
Fourth level
Fifth level
6/18/2012

#
Click to edit Master title style
Click to edit Master subtitle style
6/18/2012

#
6/18/2012

#
Click to edit Master title style
6/18/2012

#
Click to edit Master title style
Click to edit Master text styles
Click to edit Master text styles
Second level
Third level
Fourth level
Fifth level
Click to edit Master text styles
Click to edit Master text styles
Second level
Third level
Fourth level
Fifth level
6/18/2012

#
Click to edit Master title style
Click to edit Master text styles
Second level
Third level
Fourth level
Fifth level
Click to edit Master text styles
Second level
Third level
Fourth level
Fifth level
6/18/2012

#
Click to edit Master title style
Click to edit Master text styles
6/18/2012

#
Click to edit Master title style
Click to edit Master text styles
Second level
Third level
Fourth level
Fifth level
6/18/2012

#
Click to edit Master title style

Click to edit Master text styles
6/18/2012

#
Click to edit Master title style
Click to edit Master text styles
Second level
Third level
Fourth level
Fifth level
Click to edit Master text styles
6/18/2012

#
Click to edit Master title style
Click to edit Master text styles
Second level
Third level
Fourth level
Fifth level
6/18/2012

#
Click to edit Master title style
Click to edit Master text styles
Second level
Third level
Fourth level
Fifth level
6/18/2012

#