Model compounds of galactose oxidase

Model Compounds of Garrv M i’vIockler. University of Wollongong, Australia Roger Kanitz, University of Wollongong, Australia Margaret Sheil, University of Wollongong, Australia Cody Szczepina, University of Wollongong, Australia Ray J Butcher, Howard University, United States Copper(B) complexes, C&B where LH, is a Schiff Base ligand formed by the maceion of sali~y~a~ yridine or imidazole, oxidize sugars to the corresponding aldehydes in basic solutions usi methanol/water or water as the solvent. Two moles of the copper ~ornpl~~ react w fs pyridine, Cu,O is precipitated during the redox reaction. Where B is ~m~dazole,Cu(I the reaction. Cu(I)LH re-oxidises to form the starting material in the presence of oxygen and may then be reused to oxidise more sugar. A possible new method to classify the types of copper in biological systems will be discussed.

ine tuning of phosphodiesterass sing allosteric effect of Larisa A Mokhir, Anorganisch-Chemisches Institut, Universitat Heidelberg, Germany rkus Eloppe, Anorganisch-Chemisches Institut, Universitai Heidelberg, Germany ns Pritzkow, Anorganisch-Chemisches Institut, Universitat Heidelberg, Germany r 0 Fritsky, Anorganisch-Chemisches Institut, Universitat Heidelberg, Germany land ~raemer, Anorganisch-Chemisches Institut, Universitat Heidelberg, Germany In enzyme catalysisallosteric regulation is the control of activity by noncovaIent modifiers (rno~e~~l~s or ions) which bind to the enzyme at a site other than the active site but alter the conformation ofthe active site. pes of synthetic alloste& eta1complexes of polypyridyl ligands which may be considered as pro Iraospf;odieste~,catalytis a&& is ~bile two ‘functional’ copper (II) ions cooperate in the cleavage o ature of a third “structural’ (or allosteric) metal ion Ms. ere we present the expansion of this concept to structurally different ligand systems ca complexes. , R. Kramer, Angew. Chem., 2000,112,3403; . Ott, I-I. Pritzkow, R. Kramer, Chem. Eur. J., 2000,7, I22 1.; L. J. Inorg.