Low dosage clozapine effects on L-dopa induced dyskinesias in parkinsonian patients

Copyright 0 Munksgaard 1998 ACTA NEUROLOGICA SCANDINAVICA ISSN 0001-6314

Acta Neurol Scand 1998: 97: 295-299 Printed in U K - all rights reserved

Low dosage clozapine effects on L-dopa induced dyskinesias in parkinsonian patients Pierelli F, Adipietro A, Soldati G, Fattapposta F, Pozzessere G, Scoppetta C. Low dosage clozapine effects on L-dopa induced dyskinesias in parkinsonian patients. Acta Neurol Scand 1998: 97: 295-299. 0 Munksgaard 1998.

Objectives - The aim of this study was to investigate the clinical efficacy of clozapine, an atypical neuroleptic, on L-dopa induced dyskinesias of Parkinson’s disease. Material and methods - In an open study, a group of 10 PD patients was treated with low dosage clozapine (mean 30 mg/day) for a 4-month period and L-dopa dyskinesias were evaluated in basal conditions and during clozapine treatment after the usual morning dose of clozapine. We utilized the AIMS for evaluation of dyskinesias and UPDRS for the assessment of motor performances. Results - Clozapine produced a significant (P