Influence of intraperitoneal vancomycin on peritoneal dialysis efficiency. A clinical study

International Urology and Nephrology 29 (3), pp. 385-389 (1997)

Influence of Intraperitoneal Vancomycin on Peritoneal Dialysis Efficiency. A Clinical Study L. JANICKA,* A. KSI~ZEK,* J. SOLSKI,** K. JANICKI*** Departments of*Nephrology, **ClinicalAnalytics and ***Surgery,Medical Academy, Lublin, Poland (Accepted December 30, 1996)

Peritonitis is a major complication of intermittent peritoneal dialysis (IPD); over 70% of the infections are caused by Gram-positivebacteria. Vancomycin (V) is the antibiotic of choice in the treatment of peritonitis caused by G(+). The influence of vaneomycin on peritoneal transport in IPD patients has not been described before. We have investigated the effect of intraperitoneal vancomycinon dialysis efficiency in 8 IPD patients using dialysis solutions containing either lactate or acetate. The following parameters were measured: net ultrafiltration (UF), concentration ratios (D/P) of urea, creatinine, potassium, peritoneal clearances (ml/min) of urea, creatinine, potassium, mass transfer of sodium (MT~,), sodium sieving index (SC~a). It has been found that vaneomycin significantly decreases D/P urea (p