Influence of enalapril on experimental cyclosporin A nephrotoxicity

Pediatr Nephrol (1996) 10:616- 620 9 IPNA 1996

t hr oW Original article Influence of enalapril on experimental cyclosporin A nephrotoxicity Ali Anarat 1, Aytul Noyan 1, Gulfiliz Gonlusen 2, Naci Duman 1, and Ilhan Tuncer 2 l Departmentof Pediatric Nephrology,Cukurova University School of Medicine, Adana, Turkey 2 Department of Pathology,CukurovaUniversitySchool of Medicine, Adana, Turkey Received May 2, 1995; received in revised form September22, 1995; accepted January 5, 1996

Abstract. The purpose of this study was to investigate if enalapril could be administered with cyclosporin A (CyA) to reduce its nephrotoxicity. Sixty rats were divided into five groups: group I, Control group; group II, rats treated with oral enalapril; group III, rats treated with CyA; group IV, rats treated with CyA and enalapril; group V, rats treated with enalapril before the CyA therapy. At the end of the therapy mean serum creatinine concentrations were not statistically different between the groups (P>0.05), in groups treated with CyA there were no statistically significant differences between mean CyA levels (P > 0.05), and mean blood urea nitrogen levels of the groups treated with CyA were significantly elevated (P