D107 Metoclopramide attenuates pressor response to handgrip in postmenopausal women

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A]H-APIUL 1997-VOL. 10, NO. 4, PART 2

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CARDIOVASCULAR RESPONSE TO HANDGRIP IN HYPERTENSIVE SUBJECTS:A study by gender and under metoclopramide treatment.

iWETQCLOPRANttDE’ AITENtfA~PR~”REWONSE TO HANDGRIP IN POSTMENOPAUSAL WOMEN Velasco Manuel, Blanco Gabriela and Blanco Mario. Clinical Pharmacology Unit, Vargas Medical School,Central University of Venezuela,Caracas,Venezuela,SA.

Blanco Mario, Blanco Gabriela and Velasco Manuel. Clinical Pharmacology Unit, Vargas Medical School,Central University of Venezuela,Caracas,Venezuela,SA. Metoclopramide( MTC),a DA2 dopaminergic blocker reduces blood pressure in both normotensive and hypertensive subjects during cold presser test(M.Blanco et al Int J Clin.Pharmac Therap 34:390-392, 1996),treadmill exercise test(M.Blanco et al Amer. J.Therap.in press,1996).in the present study we are reporting a comparative evaluation between hypenensive (men and women)and defining MTC induced hypotensive action. Twenty hypertensive subjects(men and women) were studied.After I hour restingsubjects were submitted to the following experimental design: I)Two periods of placebo by using iv 5% glucose solution, before and after administration of MTC at the dose of 7.5uglKglmin.At the end of each period we measured blood pressure and heart rate prior, during and nfter handgrip test. Results:I )Hypertensive men:in placebo period I,HG increased BP from 158/102 to 174/119 and to 187/1!9 mmHg at I and 2 min,respectively .After MTC,pressor response to HG was 169/1I I and 176/102 mmHg,at I and 2 mirt,respectively. 2)Hypertensive women.in placebo period I,BP increased fmm 146/95 to 177/103 mmHg and to 192/101 mmHg,at land 2 min,respectively .After MTC infusion, blood pressure was reduced from 142/83 mmHg and during HG,the increment of I and 2 min,respectively. 162/97 mmHg to 168/91 mmHg at Conclusions: I)The hypertensive women exhibits greater reactivity to HG ,and 2) Hypotensive effect of MTC is more evident in women.

Metoclopramide( MTC),a DA2 dopaminergic blocker reduces blood pressure in both normotensive and hypertensive subjects during cold presser test(M.Blanco et al Int J Clin.Pbarnmc Therap 34:390-392,1996 ),treadmill exercise test(M.Blanco et al Amer.J.Therap.in press,1996).In the present study we are repotiing the presser response to handgrip in postmenopausal women. Nineteen hypertensive women were studied.After 1 hour resting,subjects were submitted to the following experimental design:l)Two periods of placebo by using iv 5% glucose solution. before and after administration of MTC at the dose of 7.5uglKg/min. At the end of each period we measured blood pressureand heart rate prior. during and after handgrip test. Results:l) Premenopausal women(n=9).During placebo period l,there was not any increase of blood pressure.During MTC period, the increase SBP was 20 and 18 mmHg at 1 y 2 min changes without in DBP;2)Postmenopausal women(n=l O).During placeb period I,handgrip increased systolic blood pressure by 3 I and 46 mmHg at I and 2 min,respectively .DBP increased 8 and 6 mmHg at I and 2 min,respectively .During MTC,pressor response to handgrip was reduced by 50?AThe increase of HR observed during p!accbo period I was attenuated during MTC and placebo period 11.The hypotensive effect induced by MTC was only noticed in premenopausal women. Conclusions:handgrip induces an exaggerated response and significantly geater in postmenopausal women and this increase is attenuated by iv MTC.

Key Words: Metoclmamide,handgrip, gendcr,hypertcnsion

Key Words:

Metocl.nrnmidr mtihwwwtemive handvrin wmwn

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CARDIOVASCULAR RESPONSE TO THE HANDGRIP IN CHiLDREN:influence of the familiar cardiovascular risk and the body mass index. Bianco Mario, Blanco Gabriela,Parada Maria Isabel and Velasco Manuel. Clinical Pharmacology Unit,Vargas Medical School,Central University of Venezuela,Caracas,Ve.ezuela,SA.

EFFECT OF METOCLOPRAMIDE ON HANDGRIP IN HYPERTENSIVE SUBJECTS. Blanco Mario, Blanco Gabriela and Velmco Manuel. Clinical Pharmacology Unit, Vargas Medical SchOOLCelltral University of Venezuela,Caracas.Venezuela,SA.

the response evaluate cardiovascular Objetive:to handgrip(HG)in scholars and to interrelate it with the falimiar cardiovascular risk precedentesandthe body mass index in bonr and currents. We studied 83 children between 7 and 10 years and gender.1{ was indicated minimal rest of 10 minutes and was proceeded [o acomplish the HG during two minutes.lt was measured the arterial pressure(SBP/DBP)and hean rate(HR)before. during and after the HG with Dynamap,being each child his own control. Results:I )7% presented greater values to the percentile 95% according to height,weight. age and gender.b)35°4 presentuf vascular hyperreactivity to the HG(16/27 and 20/23 mmHg at I and 2 Iminutes,respectively compared with normomeactors that presented values of 10/12 and 12/13 mmHg at 1 and 1 minutes,respectively .p