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Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector

May 28, 2017 | Autor: Nick Edwards | Categoría: Flow Cytometry, Infectious Diseases, Biological Sciences, Humans, Animals, DNA vaccines, Infectious, Tumor necrosis factor-alpha, Protozoan Proteins, Epitopes, Malaria Vaccines, Interleukin, Interferon gamma, DNA vaccines, Infectious, Tumor necrosis factor-alpha, Protozoan Proteins, Epitopes, Malaria Vaccines, Interleukin, Interferon gamma
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Descripción

Vaccine development in human Plasmodium falciparum malaria has been hampered by the exceptionally high levels of CD8(+) T cells required for efficacy. Use of potently immunogenic human adenoviruses as vaccine vectors could overcome this problem, but these are limited by preexisting immunity to human adenoviruses.
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