Ape parasite origins of human malaria virulence genes

June 5, 2017 | Autor: Sesh Sundararaman | Categoría: Genomics, Plasmodium, Host Parasite Interaction, Plasmodium falciparum, Virulence and Pathogenesis
Share Embed


Descripción

Antigens encoded by the var gene family are major virulence factors of the human malaria parasite Plasmodium falciparum, exhibiting enormous intra-and interstrain diversity. Here we use network analysis to show that var architecture and mosaicism are conserved at multiple levels across the Laverania subgenus, based on var-like sequences from eight single-species and three multi-species Plasmodium infections of wild-living or sanctuary African apes. Using select whole-genome amplification, we also find evidence of multi-domain var structure and synteny in Plasmodium gaboni, one of the ape Laverania species most distantly related to P. falciparum, as well as a new class of Duffy-binding-like domains. These findings indicate that the modular genetic architecture and sequence diversity underlying var-mediated host-parasite interactions evolved before the radiation of the Laverania subgenus, long before the emergence of P. falciparum.
Lihat lebih banyak...

Comentarios

Copyright © 2017 DATOSPDF Inc.