396 Estrogen Suppresses Mucosal Cytokine Responses to Microbial Ligands

AGA Abstracts

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in these events could lead to novel therapies. This was supported in part by an InvestigatorSponsored Study Program by AstraZeneca and from the NIH-NIDDK.

Age of Diagnosis Influences Serologic Responses in Children with Crohn Disease: A Possible Clue to Etiology? James Markowitz, Subra Kugathasan, Marla C. Dubinsky, Mei Ling, Wallace Crandall, Neal S. LeLeiko, Maria Oliva-Hemker, Joel R. Rosh, Jonathan Evans, David R. Mack, Anthony R. Otley, Marian D. Pfefferkorn, Ron J. Bahar, Eric A. Vasiliauskas, Ghassan Wahbeh, Gary Silber, J. Antonio Quiros, Iwona T. Wrobel, Justin Nebel, Carol J. Landers, Yoana Picornell, Kent D. Taylor, Jerome I. Rotter, Stephan R. Targan, Jeffrey S. Hyams

396 Estrogen Suppresses Mucosal Cytokine Responses to Microbial Ligands Mirjam Looijer-van Langen, Levinus A. Dieleman, Hugo Diaz, Brendan Diederichs, Karen Madsen

Determining serologic profiles to cellular and microbial antigens has become an important means of characterizing patients with IBD. AIM: To examine the influence of age at diagnosis (dx) on serologic response in a large group of children with Crohn disease (CD). METHODS: Data were drawn from the combined databases of 3 North American multicenter pediatric IBD research consortia. At or shortly after dx of CD, serologic assessments for pANCA, ASCA IgA, ASCA IgG, anti-ompC and anti-CBir1 (assayed either at the IBD Research Lab at Cedar Sinai Medical Center, Los Angeles or Prometheus Labs, San Diego) were performed. The frequencies of responses above lab reference ranges were compared as a function of age at CD dx (