Presenilin-2

Presenilin endoproteolysis is an intramolecular cleavage

Cognitive Science / Catalysis / Membrane Proteins / IP / Molecular and cellular biology / Humans / Kidney / Mutation / Mice / Animals / Active site / Presenilin-2 / App / Cellular and Molecular Neuroscience / MEF / Neurosciences / Full Length Movies / Dimerization / Humans / Kidney / Mutation / Mice / Animals / Active site / Presenilin-2 / App / Cellular and Molecular Neuroscience / MEF / Neurosciences / Full Length Movies / Dimerization

Presenilin endoproteolysis is an intramolecular cleavage

Cognitive Science / Catalysis / Membrane Proteins / IP / Molecular and cellular biology / Humans / Kidney / Mutation / Mice / Animals / Active site / Presenilin-2 / App / Cellular and Molecular Neuroscience / MEF / Neurosciences / Full Length Movies / Dimerization / Humans / Kidney / Mutation / Mice / Animals / Active site / Presenilin-2 / App / Cellular and Molecular Neuroscience / MEF / Neurosciences / Full Length Movies / Dimerization

Hippocampal hyperactivation in presymptomatic familial Alzheimer\'s disease

Magnetic Resonance Imaging / Face recognition (Psychology) / Brain Mapping / Hippocampus / Humans / Mutation / Female / Male / Young Adult / Clinical Sciences / Middle Aged / Oxygen / Adult / Presenilin-2 / Disease Progression / Annals / Alzheimer Disease / Neurosciences / Functional Laterality / Neuropsychological Tests / Mutation / Female / Male / Young Adult / Clinical Sciences / Middle Aged / Oxygen / Adult / Presenilin-2 / Disease Progression / Annals / Alzheimer Disease / Neurosciences / Functional Laterality / Neuropsychological Tests

Transition-State Analogue γ-Secretase Inhibitors Stabilize a 900 kDa Presenilin/Nicastrin Complex †

Biochemistry / Photochemistry / Membrane Proteins / Humans / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Solubility / Protease Inhibitors / Presenilin-2 / Molecular weight / Detergents / Subcellular Fractions / Protein Binding / Carbamates / Biochemistry and cell biology / Solubility / Protease Inhibitors / Presenilin-2 / Molecular weight / Detergents / Subcellular Fractions / Protein Binding / Carbamates / Biochemistry and cell biology

Características clínicas de una familia con enfermedad de Alzheimer de inicio temprano asociada a una mutación (M139T) en el gen de la presenilina 1

Mutation / Presenilin-2 / Medicina Clinica

HMGA1a: sequence-specific RNA-binding factor causing sporadic Alzheimer\'s disease-linked exon skipping of presenilin-2 pre-mRNA

Genetics / Humans / Cell Death / Endoplasmic Reticulum / ER stress / Alternative splicing / Genes / RNA-binding proteins / Presenilin-2 / Neurodegenerative Disease / Alternative Splicing / Base Sequence / Alzheimer Disease / Binding Site / Biochemistry and cell biology / Alternative splicing / Genes / RNA-binding proteins / Presenilin-2 / Neurodegenerative Disease / Alternative Splicing / Base Sequence / Alzheimer Disease / Binding Site / Biochemistry and cell biology

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

Calcium / Drosophila melanogaster / Biological Sciences / Hippocampus / Cell line / Humans / Mice / Animals / Neurons / Glycosylation / Homeostasis / Presenilin-2 / Human Fibroblasts / Lysosomes / Humans / Mice / Animals / Neurons / Glycosylation / Homeostasis / Presenilin-2 / Human Fibroblasts / Lysosomes

Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice

Cognitive Science / RNA / Aging / Immunohistochemistry / Hippocampus / Mice / Animals / Male / Cell Death / Polymerase Chain Reaction / Neurons / Clinical Sciences / Entorhinal Cortex / Presenilin-2 / Tumor necrosis factor-alpha / Biological markers / Neurosciences / Amyloid Beta Precursor Protein / Mice / Animals / Male / Cell Death / Polymerase Chain Reaction / Neurons / Clinical Sciences / Entorhinal Cortex / Presenilin-2 / Tumor necrosis factor-alpha / Biological markers / Neurosciences / Amyloid Beta Precursor Protein

Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice

Cognitive Science / RNA / Aging / Immunohistochemistry / Hippocampus / Mice / Animals / Male / Cell Death / Polymerase Chain Reaction / Neurons / Clinical Sciences / Entorhinal Cortex / Presenilin-2 / Tumor necrosis factor-alpha / Biological markers / Neurosciences / Amyloid Beta Precursor Protein / Mice / Animals / Male / Cell Death / Polymerase Chain Reaction / Neurons / Clinical Sciences / Entorhinal Cortex / Presenilin-2 / Tumor necrosis factor-alpha / Biological markers / Neurosciences / Amyloid Beta Precursor Protein

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

Structural Biology / Membrane Proteins / Cell Biology / Biological Sciences / Humans / Transferrin Receptor / CHEMICAL SCIENCES / Presenilin-2 / Amino Acid Sequence / Protein Binding / Catalytic Activity / Transferrin Receptor / CHEMICAL SCIENCES / Presenilin-2 / Amino Acid Sequence / Protein Binding / Catalytic Activity

Differential distribution of presenilin-1, Bax, and Bcl-X L in Alzheimer\'s disease and frontotemporal dementia

Dementia / Membrane Proteins / Immunohistochemistry / Temporal Lobe / Humans / Cerebral Cortex / Female / Male / Cell Death / Clinical Sciences / Aged / ACTA / Frontotemporal Dementia / Presenilin-2 / Reference Values / Alzheimer Disease / Neurosciences / Frontal Lobe / Cerebral Cortex / Female / Male / Cell Death / Clinical Sciences / Aged / ACTA / Frontotemporal Dementia / Presenilin-2 / Reference Values / Alzheimer Disease / Neurosciences / Frontal Lobe

Differential distribution of presenilin-1, Bax, and Bcl-X L in Alzheimer\'s disease and frontotemporal dementia

Dementia / Membrane Proteins / Immunohistochemistry / Temporal Lobe / Humans / Cerebral Cortex / Female / Male / Cell Death / Clinical Sciences / Aged / ACTA / Frontotemporal Dementia / Presenilin-2 / Reference Values / Alzheimer Disease / Neurosciences / Frontal Lobe / Cerebral Cortex / Female / Male / Cell Death / Clinical Sciences / Aged / ACTA / Frontotemporal Dementia / Presenilin-2 / Reference Values / Alzheimer Disease / Neurosciences / Frontal Lobe

Interactome Analyses of Mature -Secretase Complexes Reveal Distinct Molecular Environments of Presenilin (PS) Paralogs and Preferential Binding of Signal Peptide Peptidase to PS2

Membrane Proteins / Biological Chemistry / Biological Sciences / Humans / Mutation / Mice / Animals / CHEMICAL SCIENCES / Presenilin-2 / Protein Binding / Alzheimer Disease / Mice / Animals / CHEMICAL SCIENCES / Presenilin-2 / Protein Binding / Alzheimer Disease

Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death

Neurobiology Of Disease / Fear / Fourier Analysis / Humans / Mutation / Cerebral Cortex / Mice / Animals / Cell Death / Neurons / Clinical Sciences / Thallium / Presenilin-2 / Age Factors / Alzheimer Disease / Neurosciences / Amyloid Beta Precursor Protein / Cerebral Cortex / Mice / Animals / Cell Death / Neurons / Clinical Sciences / Thallium / Presenilin-2 / Age Factors / Alzheimer Disease / Neurosciences / Amyloid Beta Precursor Protein

Evaluación de la expresión de la proteínaprecursora de amiloide en células sanguíneas de pacientes con la mutación E280A en el gen de la presenilina 1

Presenilin-2

Evaluación de la producción de ß amiloide por la mutaciónE280A en el gen de la presenilina 1

Presenilin-2 / Biomedica

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