Lysosomes

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

Calcium / Drosophila melanogaster / Biological Sciences / Hippocampus / Cell line / Humans / Mice / Animals / Neurons / Glycosylation / Homeostasis / Presenilin-2 / Human Fibroblasts / Lysosomes / Humans / Mice / Animals / Neurons / Glycosylation / Homeostasis / Presenilin-2 / Human Fibroblasts / Lysosomes

Neurolysosomal pathology in human prosaposin deficiency suggests essential neurotrophic function of prosaposin

Confocal Microscopy / Ubiquitin / Humans / Child / Cerebral Cortex / Male / Astrocyte / Neurons / Clinical Sciences / Newborn Infant / Autopsy / Glial Fibrillary Acidic Protein / Lysosomes / Neurosciences / Glycosphingolipids / Lysosomal Storage Diseases / Ubiquitination / Male / Astrocyte / Neurons / Clinical Sciences / Newborn Infant / Autopsy / Glial Fibrillary Acidic Protein / Lysosomes / Neurosciences / Glycosphingolipids / Lysosomal Storage Diseases / Ubiquitination

Lipopolysaccharide Internalization Activates Endotoxin-Dependent Signal Transduction in Cardiomyocytes

Electron Microscopy / Transmission Electron Microscopy / Fluorescent Dyes and Reagents / Confocal Microscopy / Signal Transduction / Lipopolysaccharide / Cell line / Endocytosis / Animals / NF-kappa B / Phosphorylation / Clinical Sciences / Lipopolysaccharides / Rats / Nitric Oxide Synthase / Myocardium / Tumor necrosis factor-alpha / Circulation / Wistar Rats / Lysosomes / Golgi Apparatus / Boron Compounds / Lipopolysaccharide / Cell line / Endocytosis / Animals / NF-kappa B / Phosphorylation / Clinical Sciences / Lipopolysaccharides / Rats / Nitric Oxide Synthase / Myocardium / Tumor necrosis factor-alpha / Circulation / Wistar Rats / Lysosomes / Golgi Apparatus / Boron Compounds

Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration

Flow Cytometry / Treatment Outcome / Leukemia / Stem Cell / Cell line / Acute Myeloid Leukemia / Humans / Multidrug Resistance / Drug Resistance / Polymerase Chain Reaction / Clinical Sciences / Spectrum / Base Sequence / Active Transport / Lysosomes / Induced Resistance / Acute Disease / Acute Myeloid Leukemia / Humans / Multidrug Resistance / Drug Resistance / Polymerase Chain Reaction / Clinical Sciences / Spectrum / Base Sequence / Active Transport / Lysosomes / Induced Resistance / Acute Disease

MHC Class I Endosomal and Lysosomal Trafficking Coincides with Exogenous Antigen Loading in Dendritic Cells

Multidisciplinary / Dendritic Cells / Mice / Endocytosis / Animals / Antigen Presentation / PLoS one / Cell Proliferation / Lysosomes / Cytoplasm / Endosomes / MHC class I / Vacuoles / Antigen Presentation / PLoS one / Cell Proliferation / Lysosomes / Cytoplasm / Endosomes / MHC class I / Vacuoles

Cholesterol sulphate sulphohydrolase of human placenta lysosomal membrane

Humans / Placenta / Female / Enzyme / High Pressure Liquid Chromatography / Specific Activity / Molecular weight / Lysosomes / Biochemistry and cell biology / Isoelectric point / Specific Activity / Molecular weight / Lysosomes / Biochemistry and cell biology / Isoelectric point

High turnover of Tissue Factor enables efficient intracellular delivery of antibody-drug conjugates

Apoptosis / Antibodies / Humans / Mice / Animals / Drug Delivery Systems / Molecular Cancer Therapeutics / Lysosomes / Antineoplastic Agents / Immunotoxins / Drug Delivery Systems / Molecular Cancer Therapeutics / Lysosomes / Antineoplastic Agents / Immunotoxins

Plasma lysosomal glycohydrolases in a general population

Anthropometry / Humans / Female / Male / Body Mass Index / Alcohol Consumption / Enzyme / Clinical Sciences / Aged / Middle Aged / Adult / Body Mass / Sex Factors / Lysosomes / Enzymatic Activity / General Population / Ethylene Glycol / Alcohol Consumption / Enzyme / Clinical Sciences / Aged / Middle Aged / Adult / Body Mass / Sex Factors / Lysosomes / Enzymatic Activity / General Population / Ethylene Glycol

Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner

Immunology / Humans / Endocytosis / Cell Fractionation / Antigen Presentation / Dendritic cell / MHC class II / Spectrum / B Lymphocytes / Lysosomes / Endosomes / Intracellular Transport / Dendritic cell / MHC class II / Spectrum / B Lymphocytes / Lysosomes / Endosomes / Intracellular Transport

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

Oxidative Stress / Mitochondria / Biological Sciences / Cercopithecus aethiops / Humans / Animals / HeLa cells / Lysosomes / Animals / HeLa cells / Lysosomes

ISCOMATRIX Adjuvant Induces Efficient Cross-Presentation of Tumor Antigen by Dendritic Cells via Rapid Cytosolic Antigen Delivery and Processing via Tripeptidyl Peptidase II

Immunology / Phospholipids / Membrane Proteins / Immunology of the Gut / Saponins / Dendritic Cells / Signal Transduction / Cancer Vaccines / Cell Differentiation / Humans / Endocytosis / Cholesterol / Antigen Presentation / Lysosomes / Quillaja / Hydrolysis / Endosomes / Protein Transport / Dendritic Cells / Signal Transduction / Cancer Vaccines / Cell Differentiation / Humans / Endocytosis / Cholesterol / Antigen Presentation / Lysosomes / Quillaja / Hydrolysis / Endosomes / Protein Transport

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