Lysosomes

Subcellular localization of an extracellular serine protease in Leishmania (Leishmania) amazonensis

Microbiology / Parasitology / Medical Microbiology / Animals / Host-parasite interactions / Affinity chromatography / Enzyme / Subcellular Localization / Veterinary Sciences / Lysosomes / Enzymatic Activity / Serine Protease / Immunoblotting / Affinity chromatography / Enzyme / Subcellular Localization / Veterinary Sciences / Lysosomes / Enzymatic Activity / Serine Protease / Immunoblotting

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

Multidisciplinary / Cell line / Humans / Lysosomes / Parkinson Disease

Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy

Treatment Outcome / Macrophages / Humans / Endocytosis / Blood / Phosphorylation / Clinical Sciences / Phagocytosis / Diffuse Large B-Cell Lymphoma / Biological markers / Transfection / B Lymphocytes / Lysosomes / Phosphorylation / Clinical Sciences / Phagocytosis / Diffuse Large B-Cell Lymphoma / Biological markers / Transfection / B Lymphocytes / Lysosomes

ISCOMATRIX Adjuvant Induces Efficient Cross-Presentation of Tumor Antigen by Dendritic Cells via Rapid Cytosolic Antigen Delivery and Processing via Tripeptidyl Peptidase II

Immunology / Phospholipids / Membrane Proteins / Immunology of the Gut / Saponins / Dendritic Cells / Signal Transduction / Cancer Vaccines / Cell Differentiation / Humans / Endocytosis / Cholesterol / Antigen Presentation / Lysosomes / Quillaja / Hydrolysis / Endosomes / Protein Transport / Dendritic Cells / Signal Transduction / Cancer Vaccines / Cell Differentiation / Humans / Endocytosis / Cholesterol / Antigen Presentation / Lysosomes / Quillaja / Hydrolysis / Endosomes / Protein Transport

NPC1-Containing Compartment of Human Granulosa-Lutein Cells: A Role in the Intracellular Trafficking of Cholesterol Supporting Steroidogenesis

STEROIDS / Gene expression / Progesterone / Humans / Cholesterol / Female / Animals / Endoplasmic Reticulum / P-glycoprotein / Proteins / Clinical Sciences / Lysosomes / Golgi Apparatus / Granulosa Cells / Progestins / Low Density Lipoprotein (LDL) / Biochemistry and cell biology / Female / Animals / Endoplasmic Reticulum / P-glycoprotein / Proteins / Clinical Sciences / Lysosomes / Golgi Apparatus / Granulosa Cells / Progestins / Low Density Lipoprotein (LDL) / Biochemistry and cell biology

Plasma lysosomal glycohydrolases in a general population

Anthropometry / Humans / Female / Male / Body Mass Index / Alcohol Consumption / Enzyme / Clinical Sciences / Aged / Middle Aged / Adult / Body Mass / Sex Factors / Lysosomes / Enzymatic Activity / General Population / Ethylene Glycol / Alcohol Consumption / Enzyme / Clinical Sciences / Aged / Middle Aged / Adult / Body Mass / Sex Factors / Lysosomes / Enzymatic Activity / General Population / Ethylene Glycol

Role for LAMP-2 in endosomal cholesterol transport

Membrane Proteins / Cell line / Mice / Cholesterol / Animals / Endoplasmic Reticulum / Clinical Sciences / Cellular and Molecular Medicine / Lysosomes / Endosomes / Biochemistry and cell biology / Endoplasmic Reticulum / Clinical Sciences / Cellular and Molecular Medicine / Lysosomes / Endosomes / Biochemistry and cell biology

Ser72Pro active-site disease mutation in human lysosomal aspartylglucosaminidase: abnormal intracellular processing and evidence for extracellular activation

Biological Sciences / Cercopithecus aethiops / Humans / Animals / Human Molecular Genetics / Endoplasmic Reticulum / Proline / Enzyme / Active site / Enzyme activity / Amino Acid Profile / Lysosomes / Lysosomal Storage Diseases / Transient Expression / Proteolytic activity / Endoplasmic Reticulum / Proline / Enzyme / Active site / Enzyme activity / Amino Acid Profile / Lysosomes / Lysosomal Storage Diseases / Transient Expression / Proteolytic activity

Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic -cells

Fluorescence Microscopy / Western blotting / Biological Sciences / Cell line / Humans / Glucose / Insulin / cyclic AMP / Sucrose / Fluorescent Antibody Technique / Exocytosis / Amino Acid Sequence / Lysosomes / Endosomes / Glucose / Insulin / cyclic AMP / Sucrose / Fluorescent Antibody Technique / Exocytosis / Amino Acid Sequence / Lysosomes / Endosomes

CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids

Cell line / Humans / Animals / Antigen Processing / Antigen Presentation / The / Glycoproteins / Lipoprotein(a) / T lymphocytes / Amino Acids / Experimental Medicine / Amino Acid Profile / Amino Acid Sequence / Lysosomes / Recombinant Proteins / Antigens / Lipoprotein a / Molecular Structure / Lipopeptides / The / Glycoproteins / Lipoprotein(a) / T lymphocytes / Amino Acids / Experimental Medicine / Amino Acid Profile / Amino Acid Sequence / Lysosomes / Recombinant Proteins / Antigens / Lipoprotein a / Molecular Structure / Lipopeptides

Transcellular degradation of axonal mitochondria

Immunohistochemistry / Multidisciplinary / Mice / Animals / Three Dimensional Imaging / Astrocytes / Phagocytosis / Retinal Ganglion Cells / Optic Disk / Exocytosis / Lysosomes / Axons / Astrocytes / Phagocytosis / Retinal Ganglion Cells / Optic Disk / Exocytosis / Lysosomes / Axons

Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells

Cercopithecus aethiops / Humans / Animals / Cell Fractionation / Calcium Signaling / Phagocytosis / Receptors / Caveolae / Transfection / Lipid / Lysosomes / Antigens / Protein Transport / Biochemistry and cell biology / immunoglobulin G / Phagocytosis / Receptors / Caveolae / Transfection / Lipid / Lysosomes / Antigens / Protein Transport / Biochemistry and cell biology / immunoglobulin G

A cation counterflux supports lysosomal acidification

Physiology / Macrophages / Biological Sciences / Humans / Permeability / Mice / Animals / Medical Physiology / Anions / The cell / Lysosomes / Cations / Hydrogen-Ion Concentration / General Physiology / Chlorides / Mice / Animals / Medical Physiology / Anions / The cell / Lysosomes / Cations / Hydrogen-Ion Concentration / General Physiology / Chlorides

Transcellular degradation of axonal mitochondria

Immunohistochemistry / Multidisciplinary / Mice / Animals / Three Dimensional Imaging / Astrocytes / Phagocytosis / Retinal Ganglion Cells / Optic Disk / Exocytosis / Lysosomes / Axons / Astrocytes / Phagocytosis / Retinal Ganglion Cells / Optic Disk / Exocytosis / Lysosomes / Axons

A potential role for sterol carrier protein-2 in cholesterol transfer to mitochondria

Kinetics / Mitochondria / Confocal Microscopy / Mice / Cholesterol / Animals / Physical sciences / Fluorescence Imaging / Cytochrome oxidase / Enzyme / Membrane / CHEMICAL SCIENCES / Fluorescent Antibody Technique / Fluorescence polarization / Transfection / Ergosterol / Lysosomes / Recombinant Proteins / PLANT PROTEINS / Low Density Lipoprotein (LDL) / Chemistry physics / Animals / Physical sciences / Fluorescence Imaging / Cytochrome oxidase / Enzyme / Membrane / CHEMICAL SCIENCES / Fluorescent Antibody Technique / Fluorescence polarization / Transfection / Ergosterol / Lysosomes / Recombinant Proteins / PLANT PROTEINS / Low Density Lipoprotein (LDL) / Chemistry physics

Type C Niemann-Pick disease: dimethyl sulfoxide moderates abnormal LDL-cholesterol processing in mutant fibroblasts

Biological Sciences / Humans / Physical sciences / Fluorescent Antibody Technique / Homeostasis / Lysosomes

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